RIFAMPICIN+ISONIAZID+PYRAZINAMIDE
About RIFAMPICIN+ISONIAZID+PYRAZINAMIDE
RIFAMPICIN+ISONIAZID+PYRAZINAMIDE belongs to the group of medicines called 'anti-tuberculosis drugs' primarily used to treat tuberculosis. Also known as TB, Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine, and bone marrow. RIFAMPICIN+ISONIAZID+PYRAZINAMIDE does not work against infections caused by the virus, including cold and flu.
RIFAMPICIN+ISONIAZID+PYRAZINAMIDE is a combination of three anti-tuberculosis drugs, namely: Rifampicin, Isoniazid and Pyrazinamide. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Pyrazinamide inhibits the growth of the bacteria. Together, RIFAMPICIN+ISONIAZID+PYRAZINAMIDE kills Mycobacterium tuberculosis which causes TB (tuberculosis).
Take RIFAMPICIN+ISONIAZID+PYRAZINAMIDE as prescribed. In some cases, you may experience certain common side-effects such as weakness, nausea, vomiting, stomach pain, and joint or muscle pain. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer, while taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE as they might cause interaction. Maintain a gap of one hour between RIFAMPICIN+ISONIAZID+PYRAZINAMIDE and antacid medicines. Consult your doctor before taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE if you are pregnant. Avoid breastfeeding while taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE as it passes into breast milk.
Uses of RIFAMPICIN+ISONIAZID+PYRAZINAMIDE
Medicinal Benefits
RIFAMPICIN+ISONIAZID+PYRAZINAMIDE is a combination of three anti-tuberculosis drugs, namely: Rifampicin, Isoniazid, and Pyrazinamide. RIFAMPICIN+ISONIAZID+PYRAZINAMIDE belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat tuberculosis. Rifampicin inhibits DNA dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Pyrazinamide inhibits the growth of the bacteria. Together, RIFAMPICIN+ISONIAZID+PYRAZINAMIDE kills Mycobacterium tuberculosis which causes TB (tuberculosis).
Directions for Use
Storage
Side Effects of RIFAMPICIN+ISONIAZID+PYRAZINAMIDE
- Weakness
- Nausea
- Vomiting
- Stomach pain
- Joint or muscle pain
Patients Concern
Disease/Condition Glossary
Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as the kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease which can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or with normal breathing, unexplained fatigue, fever, night sweats, loss of appetite and weight. People who smoke or consume alcohol, people diagnosed with HIV, and immune system problems are more likely at risk of developing active TB.
FAQs
RIFAMPICIN+ISONIAZID+PYRAZINAMIDE is a combination of three anti-tuberculosis drugs, namely: Rifampicin, Isoniazid, and Pyrazinamide. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Pyrazinamide inhibits the growth of the bacteria. Together, RIFAMPICIN+ISONIAZID+PYRAZINAMIDE kills Mycobacterium tuberculosis which causes TB (tuberculosis).
Do not stop taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE despite symptomatic relief. To treat your condition effectually, continue taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE for as long as it has been prescribed for you.
Do not take RIFAMPICIN+ISONIAZID+PYRAZINAMIDE along with antacids as it might decrease the effectiveness of RIFAMPICIN+ISONIAZID+PYRAZINAMIDE. Maintain a minimum gap of 1 hour between both.
Consult your doctor before taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE with other medicines. Medicines used to treat TB, such as PAS (P-amino salicylic acid) and cycloserine, should be taken 8 hours apart from RIFAMPICIN+ISONIAZID+PYRAZINAMIDE if prescribed.
RIFAMPICIN+ISONIAZID+PYRAZINAMIDE contains isoniazid which might interact with foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer. Avoid these foods while taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE.
RIFAMPICIN+ISONIAZID+PYRAZINAMIDE might decrease the effectiveness of oral contraceptives (birth control pills). This could lead to an unplanned pregnancy. Instead, use a reliable barrier method of contraception such as condoms or the coil while taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE. Consult your doctor if you have any concerns regarding this; your doctor may suggest an alternate method of contraception.
RIFAMPICIN+ISONIAZID+PYRAZINAMIDE may cause discolouration of teeth, sweat, urine, sputum (phlegm), saliva, or tears. The colour in tears may last for some time, even after you stop taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE. Do not worry as it is a common side-effect of RIFAMPICIN+ISONIAZID+PYRAZINAMIDE.
Yes, RIFAMPICIN+ISONIAZID+PYRAZINAMIDE might permanently stain soft contact lenses. Use spectacles and avoid wearing contact lens while taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE.
RIFAMPICIN+ISONIAZID+PYRAZINAMIDE may affect test results of some blood tests such as tests for folate, vitamin B12, and liver function. Inform the person doing the tests that you are taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE.
RIFAMPICIN+ISONIAZID+PYRAZINAMIDE may cause liver problems, especially in people aged 35 and older. Consult your doctor if you notice symptoms such as yellowing of eyes or skin, dark urine, pale stools, weakness, loss of appetite, nausea or vomiting. Your doctor may advise you to get regular liver tests while taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE to check how your liver is functioning.
