Telmisartan+rosuvastatin
About Telmisartan+rosuvastatin
Rosuvastatin+telmisartan belongs to the class of medicines called anti-hypertensives used in the treatment of high blood pressure associated with high cholesterol levels. High blood pressure and high levels of cholesterol are two diseases that occur simultaneously in certain patients. Hypertension or high blood pressure is a chronic condition in which the force exerted by the blood against the artery wall is high. High cholesterol known as hyperlipidemia or dyslipidemia occurs when there is an excess of the unhealthy balance of cholesterol in the blood.
Rosuvastatin+telmisartan is a combination of Telmisartan (angiotensin II receptor antagonists) and Rosuvastatin (HMG CoA reductase inhibitors). Telmisartan is a blood pressure-lowering medicine that works by blocking the action of a hormone called angiotensin II in the body that causes the narrowing of blood vessels leading to high blood pressure. Thereby, it widens and relaxes blood vessels. This lowers high blood pressure. Rosuvastatin is a lipid-lowering medicine that works by blocking liver enzymes (HMG-CoA-reductase) causing the liver to make less cholesterol. So, it increases the uptake and breakdown of cholesterol already in the blood by the liver. Thus, Rosuvastatin+telmisartan lowers the levels of lipids known as cholesterol and triglycerides in the blood when lifestyle changes (like a low-fat diet) on their own have failed. Rosuvastatin+telmisartan helps in reducing the ‘bad’ cholesterol LDL (low-density lipoprotein) and increasing the ‘good’ cholesterol HDL (High-density lipoprotein) by blocking our body’s production of ‘bad’ cholesterol. It also improves your body’s ability to remove it from your blood.
Take Rosuvastatin+telmisartan as prescribed. Your doctor will advise you on how often you take Rosuvastatin+telmisartan based on your medical condition. In some cases, you may experience an allergic reaction, low blood pressure (Hypotension), itching of the skin, Steven Johnson syndrome (blistering of skin, mouth, eyes, and genitals), and decreased platelet cell count (thrombocytopenia). Most of these side effects of Rosuvastatin+telmisartan do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. It is important to have your lipid profile checked regularly.
Before starting Rosuvastatin+telmisartan, please inform your doctor if you have kidney disease or have undergone a kidney transplant. renal artery stenosis(narrowing of the blood vessels to one or both kidneys), liver disease, and heart trouble. Do not take Rosuvastatin+telmisartan on your own as self-medication.
Uses of Telmisartan+rosuvastatin
Medicinal Benefits
Rosuvastatin+telmisartan is used in patients suffering from coexisting Hypertension (High blood pressure) & Hyperlipidemia (High levels of cholesterol). Rosuvastatin+telmisartan improves patient compliance due to ease of dosing. Telmisartan & Rosuvastatin are the latest drugs among blood pressure and blood cholesterol-lowering drugs, having minimal side effects & more beneficial effects on a patient. Telmisartan lowers blood pressure by blocking switches/receptors of Angiotensin-Converting Enzyme II which is responsible for narrowing the blood vessels and increase blood pressure. Rosuvastatin, on the other hand, acts by blocking an enzyme in liver called HMG CoA reductase responsible for the formation of cholesterol in high levels.
Directions for Use
Storage
Side Effects of Telmisartan+rosuvastatin
- Nausea
- Dizziness
- Headache
- Constipation
- Stomach pain and discomfort
- Weakness
- Muscle pain
- Elevated potassium levels in blood
- Elevated glucose levels in blood
- Elevated liver enzymes
Drug Warnings
Talk to your doctor or pharmacist before taking Rosuvastatin+telmisartan if you have undergone kidney transplant. If you have severe respiratory failure, diabetes, thyroid, liver, kidney, or heart problems, raised aldosterone levels (water and salt retention in the body along with imbalance of various blood minerals), or renal artery stenosis(narrowing of the blood vessels in one or both kidneys) or if you regularly drink large amounts of alcohol, inform your doctor before taking Rosuvastatin+telmisartan.
Drug Interactions
Drug-Drug Interaction: Care should be exercised when Rosuvastatin+telmisartan is administered in combination with warfarin or clopidogrel (blood thinner), fibrates (gemfibrozil, fenofibrate), a medicine used to lower cholesterol (ezetimibe), antacid (aluminium hydroxide, magnesium hydroxide), erythromycin, fusidic acid (antibiotic), oral contraceptive pills, regorafenib (anti-cancer), anti-viral or anti-HIV drug (like ritonavir, lopinavir, atazanavir, simeprevir, ombitasvir, paritaprevir, dasabuvir, velpatasvir, grazoprevir, elbasvir, glecaprevir, pibrentasvir) muscle relaxant (tizanidine), antibiotics (trimethoprim), potassium supplements (potassium acetate, potassium acid phosphate, potassium bicarbonate, potassium chloride, potassium citrate, potassium gluconate, potassium iodide, and potassium phosphate).
Drug-Food Interaction: Care should be exercised when Rosuvastatin+telmisartan is taken with grape juice & fish oil. Alcoholic beverages should be avoided with Rosuvastatin+telmisartan. It may interact with potassium salt substitutes and potassium supplements resulting in hyperkalemia (high levels of potassium in the blood).
Drug-Disease Interaction: Rosuvastatin+telmisartan should be taken with caution if you have kidney problems, diabetes, thyroid gland problem (hypothyroidism), muscular problems (like rhabdomyolysis, myopathy), blood in the urine (haematuria), and protein in the urine(proteinuria). People with diabetes, cholestasis (liver disease due to the blocked flow of bile), or impaired kidney function should consult a doctor before taking Rosuvastatin+telmisartan.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionA patient is advised not to take this drug with alcohol as it may interact with telmisartan component of Rosuvastatin+telmisartan and lowers blood pressure drastically.
Pregnancy
cautionA patient is advised to take this drug only on doctors recommendation as there have been reports of interaction between foetus and Rosuvastatin+telmisartan in the first three months of pregnancy.
Breast Feeding
cautionA patient is advised to take this drug only on doctors recommendation. Not adequate data is available yet the drug may pass through mothers milk and affect child in a negative way.
Driving
cautionA patient is advised to take caution before taking this drug as in rare cases it has been found to cause dizziness during treatment with Rosuvastatin. If you feel dizzy, consult your doctor before attempting to drive.
Liver
cautionA patient is advised to take this drug only on doctors recommendation as there have been reports of interaction between liver and Rosuvastatin+telmisartan.
Kidney
safe if prescribedNo interaction between Rosuvastatin+telmisartan and kidney function has been reported yet doctors consultation is advised.
Children
cautionIt should be given in children only on doctor's recommendation as there is not appropriate data available for its use in children below 12.
Habit Forming
Diet & Lifestyle Advise
- Keep your weight under control with a BMI of 19.5-24.9.
- Do regular physical activity or exercise for at least 150 minutes per week or about 30 minutes most days of the week.
- Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
- Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
- If you are taking alcohol then only one serving for women and two servings for men is advisable.
- Quitting smoking is the best strategy to lower the risk of heart disease.
- Maintain a low salt diet and minimize eating processed foods as they contain more sodium. Try to replace salt with spices or herbs to add flavor to the food.
- Do regular exercise such as cycling, walking, jogging, dancing, or swimming for a minimum of 30 minutes per day.
- Chronic stress may also cause high blood pressure. Therefore, avoid stress by changing your expectations, the way you react in certain situations, and making time for yourself to do activities that you enjoy.
- Maintain a diet that is rich in fruits, vegetables, whole grains, and low-fat dairy products
- Avoid smoking and alcohol intake.
Special Advise
- Do not take Rosuvastatin+telmisartan if you have diabetes or occasional attacks of low blood pressure.
- Do not take it if you are allergic to telmisartan and if you are pregnant.
Patients Concern
Disease/Condition Glossary
High Blood Pressure (Hypertension): When the blood pressure rises, there is too much force develops on the lining of the arteries wall that makes the heart work harder to pump blood throughout the body. This results in damage to the blood vessels and heart. If high blood pressure is left untreated, it can lead to stroke, heart attack, heart failure, kidney failure, stroke, and eye problems.
Hyperlipidemia: There are two types of cholesterol found in our body namely good cholesterol (HDL-high-density lipoprotein) and bad cholesterol (LDL-low-density lipoprotein). Good cholesterol is good for our heart and helps in reducing the bad cholesterol in our body. On the other hand, excess bad cholesterol (LDL) leads to the risk of heart diseases like heart attack and stroke. High cholesterol known as hyperlipidemia or dyslipidemia occurs when there is an unhealthy balance of cholesterol in the blood. When there is a high level of cholesterol in the blood, your arteries get narrowed and clogged that finally contributing to heart diseases, like stroke and heart attack. Eating high-fat or high-cholesterol-containing food/drinks and genetic factors are the primary causes of high cholesterol.
FAQs
Take the missed dose as soon as possible or jump to next dose if its been too late. Never attempt to take a double dose to make up for the missed dose.
No, there has been no interaction found between hair follicles and Rosuvastatin+telmisartan. if a patient suffers from such a problem, he/she may consult a doctor immediately.
Protein of plant source has been found beneficial in heat diseases yet protein diet from animal source should be taken only on consulting with doctor. Too much of high protein diet also disturbs lipid levels in blood.
In rare cases, Rosuvastatin+telmisartan has been linked to disruption of sleep cycle. If a patient experiences any such discomfort, he/she should consult a doctor immediately.
Rosuvastatin+telmisartan has been found to cause chest pain, thus patients of angina pectoris should consult a doctor before using this medication.
Rosuvastatin+telmisartan has been found to have interaction with anti-bacterial medication (fusidic acid) and rarely cause muscle weakness, tenderness or pain, should consult a doctor before using this medication.
