Mifepristone+misoprostol
About Mifepristone+misoprostol
Mifepristone+misoprostol belongs to a group of gynaecological medications called ‘Abortifacient’ used for the medical termination of the pregnancy before 63 days after the first day of the last menses period. Mifepristone+misoprostol also works in the second trimester of pregnancy.
Mifepristone+misoprostol contains two medicines, namely: Mifepristone and Misoprostol. Mifepristone is an anti-hormone (anti-progestogen) that blocks the effects of the progesterone hormone required in women to continue the pregnancy. On the other hand, Misoprostol is a prostaglandin that increases the womb’s (uterus) contraction and dilates the cervix, thereby expelling the pregnancy. Thus, Mifepristone+misoprostol together cause termination of pregnancy and must be used one after the other for medical abortion.
A medical abortion generally involves 2-3 visits to a doctor or clinic, which includes giving medicines and then confirmation of termination of pregnancy. Following are the schedule involved in medical abortion:
- Day 1: Medical counselling and examination where doctor instructs to take one tablet of mifepristone (200 mcg)
- Day 2 to 3: You must return to the hospital/clinic 36 to 48 hours after taking the first dose of mifepristone. Your doctor will tell you about this. The tablet of Misoprostol (800 mcg) will now be given either orally or vaginally.
- Day 7 to 14: The doctor will confirm and make sure whether the medical abortion has been completed or not. If the abortion is not complete, you might require more follow-up visits.
In some cases, you may experience nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Most of these side effects of Mifepristone+misoprostol subside with time. But if vaginal bleeding does not stop, please visit the doctor immediately, as it requires immediate medical attention.
Mifepristone+misoprostol should not be stopped abruptly without consulting the doctor as it may lead to incomplete abortion. Inform your doctor before starting Mifepristone+misoprostol if you have had an ectopic pregnancy (when the womb grows in the fallopian tube), using an intrauterine device, or you are breastfeeding, any bleeding disorder or heart problem. Do not strenuous activities like running, heavy exercise, or driving to avoid excessive bleeding. The doctor will also check with ultrasound if the absorption is complete as no bleeding does not mean that abortion is complete.
Uses of Mifepristone+misoprostol
Medicinal Benefits
Mifepristone+misoprostol contains Mifepristone and Misoprostol. Mifepristone works by blocking the effect of progesterone (female hormone) needed to maintain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for Mifepristone+misoprostol to show effect. Once it starts acting, you will experience uterine bleeding. But no uterine bleeding does not mean that the abortion is complete. On the other hand, the second medicine is Misoprostol, a prostaglandin analogue that helps increase uterine contractions and relaxes the cervix. Thus Together Mifepristone+misoprostol terminates the state of pregnancy. Misoprostol should be taken at least 24-36 hours after taking mifepristone, either orally or vaginally. This is a non-surgical method which is 90% successful.
Directions for Use
Storage
Side Effects of Mifepristone+misoprostol
- Nausea
- Uterine cramps
- Vomiting
- Diarrhoea
- Dizziness
- Infection following abortion
- Uterine bleeding
Patients Concern
Disease/Condition Glossary
Medical abortion: It is a procedure in which medicine is used to terminate a pregnancy. It is effectively causing abortion if performed in the first 70 days of pregnancy. Vagina bleeding occurs, and if it does not stop, please inform your doctor as it might require medical supervision. Having a medical abortion is a very emotional decision. You should be mentally prepared for all the risks a surgical absorption could lead to, like incomplete abortion, heavy and prolonged bleeding (may last up to 30 days), fever, digestive system discomfort fever. Also, if the medication does not work, it can lead to an unwanted ongoing pregnancy, leading to fetal defects. So, to avoid any complications, keep in regular touch with your doctor and do as advised.
FAQs
Mifepristone+misoprostol contains Mifepristone and Misoprostol. Mifepristone works by blocking the effect of progesterone (female hormone), which is needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. Misoprostol is a prostaglandin analogue that helps increase uterine contractions and relaxes the cervix. Misoprostol should be taken 24-36 hours after taking mifepristone, either orally or vaginally.
No, Mifepristone+misoprostol should be taken in the dose and duration as advised by the doctor. Taking it in more than the recommended dose might cause unpleasant side effects like excessive uterine or vaginal bleeding.
No, Mifepristone+misoprostol is not known to affect any future chances of pregnancy. Mifepristone+misoprostol is used for medical abortion of early or unwanted pregnancy.
After taking Mifepristone+misoprostol, you may or may not experience vaginal bleeding, which does not indicate complete abortion. Your doctor will examine with the performing ultrasonography to confirm if the abortion is complete.
Do not take Mifepristone+misoprostol, if you have a heart fitted with an artificial valve, heart diseases like high blood pressure or high blood cholesterol levels (increased fat in your blood), have asthma, have blood clot problems, have a bleeding disorder, have liver or kidney disease, have anaemia (low haemoglobin) or otherwise malnourished. Taking Mifepristone+misoprostol in these conditions can cause life-threatening conditions in an individual.
