Rifampicin+isoniazid
About Rifampicin+isoniazid
Isoniazid+rifampicin belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as the kidneys, brain, spine, and bone marrow.
Isoniazid+rifampicin is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, Isoniazid+rifampicin kills Mycobacterium tuberculosis which causes TB (tuberculosis).
In some cases, you may experience certain common side-effects such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, gas, and numbness or tingling sensation. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Consult your doctor before taking Isoniazid+rifampicin if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Isoniazid+rifampicin as it passes into breast milk. Isoniazid+rifampicin may cause dizziness, and vision problems, so drive only if you are alert. Avoid alcohol consumption while taking Isoniazid+rifampicin as it could lead to increased drowsiness, dizziness and liver damage.
Uses of Rifampicin+isoniazid
Medicinal Benefits
Isoniazid+rifampicin is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, Isoniazid+rifampicin kills Mycobacterium tuberculosis which causes TB (tuberculosis).
Directions for Use
Storage
Side Effects of Rifampicin+isoniazid
- Drowsiness
- Dizziness
- Headache
- Weakness
- Muscle pain
- Heartburn
- Diarrhoea
- Gas
- Numbness
Drug Warnings
Do not take Isoniazid+rifampicin if you are allergic to any of its contents; if you have jaundice, or if you are taking HIV medicines (saquinavir or ritonavir). Before starting Isoniazid+rifampicin, please inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems. Consult your doctor before taking Isoniazid+rifampicin if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Isoniazid+rifampicin as it passes into breast milk. Isoniazid+rifampicin may cause dizziness, and drowsiness, so drive only if you are alert. Avoid alcohol consumption while taking Isoniazid+rifampicin as it could lead to increased drowsiness, dizziness and liver damage.
Drug Interactions
Drug-Drug Interactions: Isoniazid+rifampicin may interact with anti-HIV (saquinavir, ritonavir), pain killer (acetaminophen, hydrocodone), anti-depressant (duloxetine, bupropion), calcium channel blocker (diltiazem), anti-TB (ethambutol, pyrazinamide), and vitamins (ergocalciferol, cholecalciferol).
Drug-Food Interactions: Do not consume alcohol while taking Isoniazid+rifampicin as it could lead to increased dizziness and liver damage. Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer while taking Isoniazid+rifampicin as they might cause interaction.
Drug-Disease Interactions: Inform your doctor if you have colitis (inflammation in the lining of the colon), peripheral neuropathy (numbness and pain in hands and feet), porphyria, haemodialysis, liver toxicity, kidney and liver dysfunction.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid alcohol consumption while taking Isoniazid+rifampicin as it could lead to increased drowsiness, dizziness and liver damage.
Pregnancy
cautionPlease consult your doctor if you are pregnant, your doctor will prescribe Isoniazid+rifampicin only if the benefits outweigh the risks.
Breast Feeding
unsafeIsoniazid+rifampicin passes into breast milk. Do not breastfeed while taking Isoniazid+rifampicin.
Driving
cautionIsoniazid+rifampicin may cause dizziness, drowsiness, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.
Liver
cautionDose adjustment may be needed. Please consult your doctor before taking Isoniazid+rifampicin if you have liver impairment/liver disease.
Kidney
cautionDose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking Isoniazid+rifampicin.
Children
consult your doctorPlease consult your doctor. Your doctor may suggest suitable dose and dosage form based on your child's age, body weight and medical condition. Kid tablets could be used in children if prescribed by the doctor.
Habit Forming
Diet & Lifestyle Advise
- Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
- Foods rich in vitamin C such as kiwi, broccoli, and bell pepper helps in improving the immune system.
- Avoid processed and fried foods.
- Warm ginger tea or warm soup can help in providing relief from cough.
- Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
- Quit smoking and avoid alcohol consumption.
Special Advise
- Isoniazid+rifampicin may affect test results of some blood tests such as tests for folate, vitamin B12, and liver function. Inform the person doing the tests that you are taking Isoniazid+rifampicin.
- Your doctor may advise you to get regular liver tests while taking Isoniazid+rifampicin to check how your liver is functioning.
Patients Concern
Disease/Condition Glossary
Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease which can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or with normal breathing, unexplained fatigue, fever, night sweats, loss of appetite and weight. People who smoke or consume alcohol, people diagnosed with HIV, and immune system problems are more likely at risk of developing active TB.
FAQs
Isoniazid+rifampicin is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, Isoniazid+rifampicin kills Mycobacterium tuberculosis which causes TB (tuberculosis).
Do not stop taking Isoniazid+rifampicin despite symptomatic relief. To treat your condition effectually, continue taking Isoniazid+rifampicin for as long as it has been prescribed for you.
Do not take Isoniazid+rifampicin along with antacids as it might decrease the effectiveness of Isoniazid+rifampicin. Maintain a minimum gap of 1hour between both.
Consult your doctor before taking Isoniazid+rifampicin with other medicines. Medicines used to treat TB such as PAS (P-amino salicylic acid) and cycloserine should be taken 8hours apart from Isoniazid+rifampicin.
Isoniazid+rifampicin contains isoniazid which might interact with foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer. Avoid these foods while taking Isoniazid+rifampicin.
Isoniazid+rifampicin might decrease the effectiveness of oral contraceptives (birth control pills). This could lead to an unplanned pregnancy. Instead, use a reliable barrier method of contraception such as condoms or the coil while taking Isoniazid+rifampicin. Consult your doctor if you have any concerns regarding this; your doctor may suggest an alternate method of contraception.
Isoniazid+rifampicin may cause discolouration of teeth, sweat, urine, sputum (phlegm), saliva, or tears. The colour in tears may last for some time even after you stop taking Isoniazid+rifampicin. Do not worry as it is a common side-effect of Isoniazid+rifampicin.
Yes, Isoniazid+rifampicin might permanently stain soft contact lenses. Use spectacles and avoid wearing contact lens while taking Isoniazid+rifampicin.
Isoniazid+rifampicin may affect test results of some blood tests such as tests for folate, vitamin B12, and liver function. Inform the person doing the tests that you are taking Isoniazid+rifampicin.
Yes, Isoniazid+rifampicin may cause liver problems, especially in people who are 35 and older. Consult your doctor if you notice symptoms such as yellowing of eyes or skin, dark urine, pale stools, weakness, loss of appetite, nausea or vomiting. Your doctor may advise you to get regular liver tests while taking Isoniazid+rifampicin to check how your liver is functioning.
