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EFAVIRENZ+ZIDOVUDINE+LAMIVUDINE

About

EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE belongs to the class of medications called ‘antiretroviral agents’ used to treat HIV infection. HIV is a virus that attacks the immune cells of the body leading to decreased immunity. It spreads through body fluids such as semen, vaginal fluid and blood. Symptoms include fever, chills, rash, night sweats, muscle aches, tiredness, and sore throat that usually last for days to several weeks.

EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE is a combination of three medicines: Efavirenz, zidovudine, and lamivudine. These drugs belong to a group of medicines called nucleoside analogue reverse transcriptase inhibitors. They work by inhibiting the reverse transcriptase enzyme from working, which is required by the HIV-infected cells to make new viruses. This effect helps to inhibit viral replication.

You should take this medicine exactly as prescribed by the doctor. EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE may cause side effects such as headache, tiredness, dizziness, drowsiness, vomiting, diarrhea, insomnia, nightmare, muscle damage, and anemia (low number of red blood cells). Inform your doctor if any of these side effects persist or get worse.

It is not recommended to take EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE if you are allergic to any contents of it. Before taking EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE, inform your doctor if you have any liver disease, hepatitis B or C (liver infections), a history of mental illness, or are seriously overweight and have kidney disease. Inform your doctor if you are pregnant or breastfeeding. EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE should not be given to children below 2 years of age. EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE should be used with caution in elderly patients. Alcohol consumption may increase the risk of side effects. EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

Uses of EFAVIRENZ+ZIDOVUDINE+LAMIVUDINE

HIV infection

Medicinal Benefits

EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE belongs to the group of medicines called antiretroviral therapy (ART). EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE contains efavirenz, zidovudine and lamivudine. These drugs belong to a group of medicines called nucleoside analogue reverse transcriptase inhibitors. They work by inhibiting the reverse transcriptase enzyme from working, which is required by the HIV-infected cells to make new viruses. Thereby preventing viral replication and controlling the infection. It helps in improving the quality of life of a patient with HIV.

 

Directions for Use

Take EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE with food or after a meal as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of EFAVIRENZ+ZIDOVUDINE+LAMIVUDINE

  • Headache
  • Nausea
  • Dizziness
  • Drowsiness
  • Vomiting
  • Diarrhea
  • Insomnia
  • Muscle damage
  • Anemia

In-Depth Precautions and Warning

Drug Warnings

Inform your doctor if you develop persistent diarrhea or vomiting, as it may affect the effectiveness of EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE. EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE may cause pancreatitis (inflammation of the pancreas), so inform your doctor if you develop symptoms such as nausea (feeling sick), vomiting, or stomach pain. EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE may lead to opportunistic infections (infections that occur frequently or severely in patients with weak immune systems), so inform your doctor immediately if you experience symptoms of infection such as muscle weakness, weakness beginning in the hands and feet that progress towards the trunk, palpitations (pounding heartbeat), and tremors. EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE may destroy bone leading to symptoms such as joint stiffness or pain. It may also cause muscle pain, tenderness, or weakness. EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE may also cause dizziness and abnormal heartbeat. Inform your doctor immediately if you notice any significant changes in the electrocardiogram (ECG). Do not take EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE if you have severe liver disease, a slow heartbeat, or severe heart disease, a very low red blood cell count (anemia) or a very low white blood cell count (neutropenia). Speak with your doctor about the precautions to follow to avoid infecting other people as one can still pass on HIV while on this medicine, although the risk is somewhat lowered by antiretroviral therapy; it can spread through sexual contact with a person who already has the infection, or by transfer of infected blood. EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE does not cure HIV infection. EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE can make hormonal contraceptives less effective or less likely to work. So, use other effective methods for contraception, including a barrier form (cervical cap, condom, diaphragm, or contraceptive sponge) to prevent pregnancy while on EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE and for at least 12 weeks after stopping treatment as advised by your doctor. Do not breast-feed while taking this medicine. Also, do not take EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE with other medicines such as stavudine, used to treat HIV infection, ribavirin or ganciclovir to treat viral infections, rifampicin to treat bacterial infections, bepridil (used to treat heart disease), cisapride (used to treat heartburn), methadone (used to treat opiate addiction), St. John’s wort (Hypericum perforatum) (a herbal remedy used for depression and anxiety), flecainide, metoprolol (used to treat irregular heartbeat). EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE is not recommended in pregnancy as could harm the unborn baby or cause birth defects. You may need frequent medical tests while on EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE.

Drug Interactions

Drug-Drug Interactions:  Doxorubicin (medicine for cancer), ribavirin (used to treat chronic hepatitis C), stavudine(medication used to prevent and treat HIV/AIDS), emtricitabine (used to treat HIV infection), cladribine (used to treat hairy cell leukemia), bepridil (used to treat heart disease), cisapride (used to treat heartburn), methadone (used to treat opiate addiction), clomipramine (used to treat certain mental conditions).

Drug-Food Interactions: EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE may have interaction with St.John’s wort (herbal supplement used to treat depression). Avoid smoking and alcohol consumption while on this medication.

Drug-Disease Interactions: EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE should not be used in patients with liver disease, hepatitis B or C (liver infections), mental illness or psychosis, heart disease.

Drug-Drug Interactions Checker List:

  • DOXORUBICIN
  • RIBAVIRIN
  • STAVUDINE
  • CLADRIBINE
  • BEPRIDIL
  • CISAPRIDE
  • METHADONE
  • CLOMIPRAMINE
  • EMTRICITABINE
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      Consumption of alcohol may increase the risk of side-effects.

    • Safety Warning

      Pregnancy

      caution

      EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE should be used with caution in pregnant women. It is given only if clinically needed and when benefits outweigh the risk. It can harm the unborn baby or cause birth defects if taken during pregnancy.

    • Safety Warning

      Breast Feeding

      caution

      If EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE is prescribed during breastfeeding, the doctor may advise you to stop breastfeeding as this medicine can pass into breastmilk.

    • Safety Warning

      Driving

      caution

      EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

    • Safety Warning

      Liver

      caution

      EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Kidney

      caution

      EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Children

      caution

      EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE is not recommended for use in children below 2 years. In children above 2 years of age, dose adjustments may be necessary.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as dark green, yellow, orange and red vegetables, and fruit as it helps to boost your immune system. Option for lean protein and whole grains.
    • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry, or seafood.
    • Eat bland and low-fat foods and avoid spicy or oily foods if you experience nausea or vomiting.
    • Try to reduce emotional and physical stress by spending time with family or whatever makes you happy.
    • Drink more fluids and avoid alcoholic beverages to prevent dehydration. 
    • Wash your hands properly before and after eating.
    • Make sure you sleep at least 8 hours a day.

    Special Advise

    • EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE may still develop infections or other illnesses associated with HIV infection or AIDS. So, people taking EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE should be carefully monitored throughout the treatment.
    • You can still infect other people while taking EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE. So, use necessary precautions to avoid infecting others.
    • EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE may cause abnormal liver function tests. So, regular monitoring of liver function is necessary while taking this medicine.

    Patients Concern

    Disease/Condition Glossary

    HIV (human immunodeficiency virus) is a virus that attacks the immune system, making the individual susceptible to other infections or illnesses. People with HIV experience flu-like symptoms such as fever, chills, rash, night sweats, muscle aches, tiredness, and sore throat. These symptoms usually last for days to several weeks. It spreads through body fluids such as semen, vaginal fluid and blood. If left untreated, this condition can lead to AIDS (Acquired Immunodeficiency Syndrome). It is a life-long condition and there is no definite cure for it.  However, it can be controlled by treating with antiretroviral agents.

    FAQs

    EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE is a combination of three medicines: Efavirenz, zidovudine, and lamivudine. These three drugs work by inhibiting the reverse transcriptase enzyme from working, which is required by the HIV-infected cells to make new viruses. Thereby preventing viral replication and controlling the infection.

    EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE may cause side-effects such as abnormal dreams, difficulty concentrating, dizziness, blurred vision, whistling, ringing, aching muscles, difficulty in sleeping, hair loss, cough, feeling breathless. Inform your doctor if any of these side-effects persist or get worse.

    EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE doesn’t cure HIV infection. However, it helps to control the disease and prevent opportunistic infections.

    EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE may cause lactic acidosis (excess of lactic acid in the blood), a rare but a severe side effect, especially in women who are very obese. However, if you experience stomach pain, vomiting or nausea while taking EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE, please consult a doctor immediately.

    No, EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.

    If you miss a dose of EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

    Do not stop taking EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE without talking to your doctor. If you suddenly stop taking EFAVIRENZ+LAMIVUDINE+ZIDOVUDINE, you may experience confusion, fever, mental state changes or severe muscle stiffness. Your doctor will probably decrease your dose gradually depending upon your disease condition.

    Available Medicines for

    EFAVIRENZ+ZIDOVUDINE+LAMIVUDINE

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