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Ketoconazole+betamethasone

About Ketoconazole+betamethasone

Betamethasone+ketoconazole belongs to a class of drugs called 'antifungal' primarily used to treat the skin's fungal infections. It minimizes the redness, itching, pain, and inflammation of the skin caused due to fungal infections. Fungal infection is a skin disease in which a fungus attacks the tissue and causes infection. Fungal infections may be contagious (spread from one person to another).

Betamethasone+ketoconazole contains Ketoconazole (antifungal) and betamethasone (steroid). Ketoconazole works by rupturing the fungal cell membrane's outer layer, which ultimately bursts the fungal cell's cellular content, leading to its death. On the other hand, Betamethasone works by acting inside skin cells and inhibiting the release of certain chemical messengers (histamine) that cause allergic symptoms like redness, itching, and skin swelling. 

Apply this medicine in the dose and duration prescribed by your doctor. Some people may experience itching, pain, irritation, or burning sensation at the application site. Most of these side effects of Betamethasone+ketoconazole do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Betamethasone+ketoconazole can cause liver failure, so your doctor will monitor your liver function while you're taking Betamethasone+ketoconazole. If you are pregnant or a nursing mother, it is advised to consult a doctor before using the Betamethasone+ketoconazole. If you use Betamethasone+ketoconazole in topical form, avoid smoking or going near naked flames as Betamethasone+ketoconazole catches fire and burns quickly. Use of Betamethasone+ketoconazole is contraindicated in people with liver disease, asthma, sulfite allergy, an autoimmune disorder, and heart problems; inform your doctor before using Betamethasone+ketoconazole. 

Uses of Ketoconazole+betamethasone

Fungal skin infections

Medicinal Benefits

Betamethasone+ketoconazole is an antifungal that is primarily used to treat fungal infections. The fungal cell membranes are essential for their survival as they prevent unwanted substances into the cells and stop the leakage of cell contents. Ketoconazole is an antifungal that causes holes in the fungal cell membranes, thereby bursting its cellular content, ultimately killing fungi. Betamethasone is a steroid that acts inside skin cells and inhibits the release of certain chemical messengers (histamine) in the body that cause allergic symptoms like redness, itching, and swelling. This treats fungal infections and provides relief from cracking, burning, scaling, and itching of the skin caused due to conditions. 

Directions for Use

Betamethasone+ketoconazole is only for external use. Take a small amount of Betamethasone+ketoconazole on the fingertip and apply it as a thin layer on the clean and dry affected area as prescribed by your doctor. Avoid contact of the Betamethasone+ketoconazole with the nose or eyes. In case of accidental contact with these areas, rinse with water thoroughly. Wash your hands before and after using Betamethasone+ketoconazole if your hands are not the affected area to prevent the spread of infection.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Ketoconazole+betamethasone

  • Dry skin
  • Itching
  • Skin redness
  • Burning sensation 
  • Application Site Redness Of Skin

Drug Warnings

Avoid contact of Betamethasone+ketoconazole with nose, mouth, or eyes as it may irritate. If Betamethasone+ketoconazole accidentally comes in contact with these areas, rinse with water thoroughly. If you are pregnant, planning for pregnancy, or breastfeeding mother, you should consult a doctor before using Betamethasone+ketoconazole. If you use Betamethasone+ketoconazole, avoid smoking or going near naked flames as Betamethasone+ketoconazole catches fire and burns quickly. Tell your doctor before using Betamethasone+ketoconazole; if you have asthma, sulpha medicine allergy, an autoimmune disorder, or heart or liver problems, inform your doctor. Betamethasone+ketoconazole can cause serious harm to your liver that may result in a liver transplant or cause even death. Avoid using Betamethasone+ketoconazole for more than five days in children and on the face. Betamethasone+ketoconazole should not be used to treat fungal infections of the fingernails/toenails, prostate cancer, or Cushing’s syndrome. Betamethasone+ketoconazole could make your skin sensitive to the sunlight and cause sunburn more quickly, so try to avoid direct exposure to the sunlight. Apply sunscreen (SPF 30 or higher) whenever you go outdoors. 

Drug Interactions

Drug-Drug Interactions: Betamethasone+ketoconazole may interact with drugs used to lower high blood pressure (metoprolol), pain killers (aspirin, ibuprofen), antianxiety drugs (alprazolam), laxatives (magnesium sulfate), blood thinners (warfarin), treat heartburn and acidity (omeprazole), immunosuppressant (cyclosporin), glucocorticoids (fluticasone, hydrocortisone), antifungal (fluconazole), blood cholesterol-lowering medicines (atorvastatin), bronchodilators (albuterol), blood thinners (warfarin), laxative (polyethylene glycol 3350).

Drug-Food Interactions: Betamethasone+ketoconazole may interact with caffeine-containing tea, coffee, cola, and energy drinks as it may increase the adverse effects of caffeine. Do not take marijuana with Betamethasone+ketoconazole as it may worsen the adverse effects of marijuana. Also, avoid consumption of alcohol with Betamethasone+ketoconazole as it may increase the risk of liver damage.

Drug-Disease Interactions: If you have diabetes, psoriasis, glaucoma, cataracts, adrenal gland, asthma, sulfite allergy, an autoimmune disorder, or heart or liver problems, inform your doctor before taking Betamethasone+ketoconazole.

Drug-Drug Interactions Checker List:

  • METOPROLOL
  • ASPIRIN
  • IBUPROFEN
  • ALPRAZOLAM
  • MAGNESIUM SULPHATE
  • WARFARIN
  • OMEPRAZOLE
  • CYCLOSPORINE
  • FLUTICASONE
  • HYDROCORTISONE
  • FLUCONAZOLE
  • ATORVASTATIN
  • ALBUTEROL
  • POLYETHYLENE GLYCOL
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      Avoid consumption of alcohol while taking Betamethasone+ketoconazole as it may increase the risk of liver damage and cause adverse effects.

    • Safety Warning

      Pregnancy

      caution

      Betamethasone+ketoconazole is a Category C pregnancy drug and is given to a pregnant woman only if the doctor thinks benefits outweigh risks.

    • Safety Warning

      Breast Feeding

      caution

      Betamethasone+ketoconazole is excreted in human milk and is given to a breastfeeding mother only if the doctor thinks benefits outweigh risks.

    • Safety Warning

      Driving

      safe if prescribed

      Betamethasone+ketoconazole usually does not affect your ability to drive or operate machinery.

    • Safety Warning

      Liver

      caution

      Inform your doctor before receiving the Betamethasone+ketoconazole if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

    • Safety Warning

      Kidney

      caution

      Inform your doctor before receiving the Betamethasone+ketoconazole if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

    • Safety Warning

      Children

      caution

      Betamethasone+ketoconazole is not recommended for children below one year as the safety and effectiveness were not established. Please consult a doctor before using Betamethasone+ketoconazole in children.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Regularly change your socks and wash your feet. Avoid shoes that make your feet sweaty and hot.
    • Don't walk barefoot in wet places such as changing rooms and gym showers to prevent fungal infections.
    • Do not scratch the affected skin, as it can spread the infection to other body parts.
    • Avoid sharing towels, combs, bedsheets, shoes, or socks with others.
    • Wash your bed sheets and towels regularly.
    • Avoid taking Betamethasone+ketoconazole (oral form) with foods containing chocolate and caffeine, such as cocoa beans, tea, coffee, cola, and energy drinks, as it may increase the adverse effects of caffeine.
    • Avoid alcohol intake with Betamethasone+ketoconazole (oral form) as it may cause adverse effects and increase the risk of liver damage.

    Special Advise

    • Before applying the Betamethasone+ketoconazole, clean and dry the affected area.
    • Avoid contact of Betamethasone+ketoconazole with nose, mouth, or eyes. In case Betamethasone+ketoconazole comes in connection with these areas accidentally, rinse with water thoroughly.
    • Do not wash the treated areas for a minimum of 3 hours after you apply the Betamethasone+ketoconazole.
    • Use hand sanitisers regularly during fungal infection to avoid the unnecessary spread of the disease. 
    • Keep the affected area dry and free from contact with moisture or water.

    Patients Concern

    Disease/Condition Glossary

    Fungal infection: Fungal infection is a skin disease in which a fungus attacks the tissue and causes infection. Fungal infections may be contagious (spread from one person to another). Ringworm is a common fungal infection of the skin or scalp that is contagious and causes a rash resembling a worm in a ring shape. Jock itch (also known as tinea cruris) is a fungal infection of the skin that causes an itchy, red rash in warm and moist areas of the body, such as the groin, buttocks, and inner thighs. Athlete's foot (also known as tinea pedis) is a fungal infection that usually starts between the toes, especially in people who have extremely sweaty feet and wear tight-fitting shoes. It occurs most commonly in athletes. It causes itching, burning, or stinging sensation due to a scaly rash. Seborrheic dermatitis is a skin condition that causes an itchy rash with dry, flaky scales on the skin that contains oil glands such as the scalp, face, back, and upper chest.   

    FAQs

    You are recommended to avoid foods containing chocolate and caffeine such as cocoa beans, tea, coffee, cola, and energy drinks while taking Betamethasone+ketoconazole in oral form (tablets) as it may increase the adverse effects of caffeine such as drowsiness, nervousness, or nausea.

    Yes, Betamethasone+ketoconazole may cause skin reactions such as contact dermatitis (red, itchy skin rash caused by direct contact with a certain substance) as it contains stearyl alcohol and cetyl alcohol responsible for causing such skin reactions. However, if the irritation worsens or persists, please consult a doctor.

    Prolonged use of Betamethasone+ketoconazole can cause severe liver damage and heart problems like life-threatening heart rate or heart rhythm problems. So, if you are having any heart or liver disease consult a doctor before using Betamethasone+ketoconazole.

    You are recommended to use Betamethasone+ketoconazole for as long as your doctor has prescribed it. However, if the condition worsens or persists after 2 to 4 weeks of treatment with Betamethasone+ketoconazole, please consult a doctor.

    You are recommended to apply makeup or sunscreen to the treated area of skin after a minimum of 20 minutes of using Betamethasone+ketoconazole.

    No, you are not recommended to stop using Betamethasone+ketoconazole without consulting your doctor as it may cause recurring infection. Therefore, take Betamethasone+ketoconazole for as long as your doctor has prescribed it, and if you experience any difficulty while taking Betamethasone+ketoconazole, please consult your doctor.

    Betamethasone+ketoconazole contains Ketoconazole (antifungal) and betamethasone (steroid). Ketoconazole works by rupturing the fungal cell membrane's outer layer, ultimately bursting the fungal cell's cellular content, leading to its death. On the other hand, Betamethasone works by acting inside skin cells and inhibiting the release of certain chemical messengers (histamine) that cause allergic symptoms like redness, itching, and skin swelling.

    Available Medicines for

    Ketoconazole+betamethasone

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