Clarithromycin+esomeprazole+amoxicillin

Amoxicillin+clarithromycin+esomeprazole should not be used in patients with arrhythmias or taking antiarrhythmic agents, as it may lead to prolonged QT intervals, which can be life-threatening. While using Amoxicillin+clarithromycin+esomeprazole, if you notice severe or prolonged diarrhoea, vomiting food or blood, black stools, unexplained weight loss, or symptoms of liver disease (jaundice (yellowing of the skin), loss of appetite, dark urine, or itching), stop the medication and consult a doctor immediately. Besides, if you notice skin rashes or lesions, especially on sun-exposed skin, stop the treatment and immediately consult a doctor. Amoxicillin+clarithromycin+esomeprazole increases the risk of Clostridium difficile-associated diarrhoea (inflammation of the large intestine due to Clostridium infection). Amoxicillin+clarithromycin+esomeprazole may increase the risk of fractures, cause liver impairment, and impair the absorption of vitamin B12 in the body when used for prolonged periods.

Drug-Drug Interactions: Amoxicillin+clarithromycin+esomeprazole may interact with anti-gout medications (allopurinol, colchicine, and probenecid), anticoagulants (warfarin, clopidogrel), medicines used to treat diabetes (nateglinide, repaglinide, and insulin), anticancer medication (methotrexate, vinblastine, and erlotinib), antibiotics (tetracycline), anti-HIV medication (atazanavir), antidepressants (citalopram, imipramine, clomipramine, and hypericum perforatum), medication to treat fits (phenytoin, carbamazepine, and valproate), antianxiety medication (diazepam), a steroid medicine (methylprednisolone), a medicine used to treat heart problems (digoxin, verapamil, quinidine, and disopyramide), immunosuppressant (cyclosporine, sirolimus, and tacrolimus), a medicine used to treat tuberculosis (rifampicin), a medicine to treat heartburn (cisapride), a medicine used to widen blood vessels (cilostazol), antiallergic (astemizole and terfenadine), antipsychotic (pimozide and quetiapine), medicines used to treat migraine (ergotamine and dihydroergotamine), lipid-lowering drugs (lovastatin and simvastatin), and sedatives (alprazolam, triazolam, and midazolam).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Amoxicillin+clarithromycin+esomeprazole should be used with caution in patients with arrhythmias (a condition with irregular heartbeat), vitamin B12 deficiency, hypokalemia (low potassium levels in the blood), severe liver failure, severe kidney problems, heart problems, urination problems, glandular fever (fever, sore throat, swollen glands, and extreme tiredness), lymphatic leukaemia (a type of blood cancer), and HIV.

• Avoid intake of acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes, and high-fat and spicy foods.
• Before going to sleep, try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows; instead, one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.
• Avoid taking alcohol and smoking cigarettes. Alcohol can raise the level of production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), preventing stomach acid backflow into the food pipe.
• Include fibre-rich foods, berries, cherries, leafy green veggies (kale, spinach), and black peppers in your meal. These foods are full of antioxidants, calcium, and vitamin B 12 that can help cope with the medicine's long-term effects. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics that help prevent excess stomach acid production. Cranberry juice can be beneficial in peptic ulcers and H Pyroli infection.
• Avoid regular sitting continuously, as it can increase stomach acid production. Try to take a break of 5 minutes in 1 hour by brisk walking or stretching.

• Amoxicillin+clarithromycin+esomeprazole may impair liver function. So, your doctor may periodically perform liver function tests to evaluate liver function. 
• Amoxicillin+clarithromycin+esomeprazole may affect the test results of urine tests for glucose, blood tests for liver function, and oestriol tests (to check the baby is developing normally during pregnancy), so inform your doctor that you are taking Amoxicillin+clarithromycin+esomeprazole before undergoing these tests.