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  1. Home
  2. Medicine

  3. Zimpril 4 Tablet

Prescription drug
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Written By ,
Reviewed By Hari Kumar , MBBS

Composition :

PERINDOPRIL ERBUMINE-4MG

Manufacturer/Marketer :

Zim Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Therapeutic Class

ANTI- HYPERTENSIVES AND ACE INHIBITORS

Country of origin

India

Manufacturer/Marketer address

Sadoday Gyan (Ground Floor),Opp. N.A.D.T, Nelson Square, Nagpur 440013
Other Info - ZIMP852

FAQs

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

Alcohol may enhance the hypotensive (low blood pressure) effect of Zimpril 4 Tablet. It may also cause increased dizziness. For better advice, you should consult your doctor if you can take Zimpril 4 Tablet with alcohol.

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Pregnancy

Unsafe

Avoid taking Zimpril 4 Tablet if you are pregnant, especially if you are more than 3months pregnant as it may cause harm to the developing fetus. Consult your doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Use of Zimpril 4 Tablet is not recommended during the breastfeeding.

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Driving

Caution

Zimpril 4 Tablet may cause blurry vision, dizziness or weakness. Drive or operate machinery only if you are alert.

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Liver

Caution

Rare elevation in liver enzymes (like bilirubin) has been observed while taking Zimpril 4 Tablet, so it must be taken with caution. If you have a history of liver diseases/conditions, the dose may have to be adjusted by your doctor.

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Kidney

Caution

Zimpril 4 Tablet to be taken with caution, especially in case of severe kidney disease. The dose may have to be adjusted by your doctor. Zimpril 4 Tablet should be given with precaution in hemodialysis condition.

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Children

Unsafe

The safety and effectiveness of Zimpril 4 Tablet in children below 18years have not been established.

Product Substitutes

Reference

  1. https://www.healthline.com/health/perindopril-oral-tablet
  2. https://medlineplus.gov/druginfo/meds/a602017.html
  3. https://www.medicines.org.uk/emc/files/pil.4389.pdf

About Zimpril 4 Tablet

Zimpril 4 Tablet is an anti-hypertensive medication primarily used to treat high blood pressure and heart failure. It is also used to reduce the risk of cardiac events like a heart attack in patients with coronary artery disease and who have had a heart attack and/or surgery to improve the blood supply to the heart. Hypertension (High blood pressure) is a condition in which the force exerted by the blood against the artery walls becomes so high that it causes health problems, such as heart disease.

Zimpril 4 Tablet contains Perindopril erbumine, an angiotensin-converting enzyme (ACE) inhibitor; it reduces increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). Zimpril 4 Tablet relaxes and widens the blood vessels, thereby lowering the blood pressure and making it easier for the heart to pump blood throughout the body. 

Take Zimpril 4 Tablet as prescribed. Your doctor will advise you on the dosage and duration based on your medical condition. In some cases, you may experience dizziness, headache, weakness, vomiting, and nausea. Most of these side effects of Zimpril 4 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine on your own, even if your blood pressure becomes normal; doing so may worsen your condition. Avoid taking Zimpril 4 Tablet if you are pregnant or breastfeeding. Zimpril 4 Tablet is not recommended for children below 18years. Zimpril 4 Tablet may cause dizziness and weakness, so drive or operate machinery only if you are alert. Keep your doctor informed about your health condition and medications to rule out any interactions.

Uses of Zimpril 4 Tablet

Hypertension, Heart failure, Prevention of heart attack

Medicinal Benefits Mweb

Medicinal Benefits

Zimpril 4 Tablet is used to treat high blood pressure and heart failure. Additionally, it is also used to reduce the risk of cardiac events like a heart attack in patients with coronary artery disease and who have had a heart attack and/or surgery to improve the blood supply to the heart. Zimpril 4 Tablet contains Perindopril erbumine, an angiotensin-converting enzyme (ACE) inhibitor; it reduces increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). Zimpril 4 Tablet allows constricted blood vessels to relax and therefore helps lower high blood pressure.

Directions for Use

Swallow Zimpril 4 Tablet as a whole with water; do not crush or chew it.

Side Effects of Zimpril 4 Tablet

  • Cough
  • Nausea
  • Dizziness
  • Headache 
  • Vision disturbances
  • Ankle swelling
  • Weakness
  • Vomiting

Drug Warnings

Do not take Zimpril 4 Tablet if you are allergic to any of the contents, ACE inhibitors, if you are taking sacubitril, valsartan, or aliskiren. Inform your doctor if you have/had kidney problems, dialysis, heart problems, liver dysfunction, diabetes, dehydration, angioedema, collagen vascular disease, or primary aldosteronism. Consult your doctor if you develop signs of infection or jaundice. Avoid taking Zimpril 4 Tablet if you are pregnant or breastfeeding. Zimpril 4 Tablet is not recommended for children below 18years. Zimpril 4 Tablet may cause dizziness and weakness, so drive or operate machinery only if you are alert. Keep your doctor informed about your health condition and medications to rule out any interactions.

Drug-Drug Interactions

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PerindoprilAliskiren
Critical
PerindoprilMipomersen
Severe

Drug-Drug Interactions

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PerindoprilAliskiren
Critical
How does the drug interact with Zimpril 4 Tablet:
Combining Aliskiren with Zimpril 4 Tablet can increase the risk of low blood pressure, high potassium levels, and kidney damage.

How to manage the interaction:
Taking Zimpril 4 Tablet with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PerindoprilMipomersen
Severe
How does the drug interact with Zimpril 4 Tablet:
Using Zimpril 4 Tablet together with mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Zimpril 4 Tablet with Mipomersen can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
PerindoprilTizanidine
Severe
How does the drug interact with Zimpril 4 Tablet:
Combining Tizanidine with Zimpril 4 Tablet can increase the risk of low blood pressure.

How to manage the interaction:
Co-administration of Tizanidine with Zimpril 4 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
PerindoprilPiroxicam
Severe
How does the drug interact with Zimpril 4 Tablet:
Using Zimpril 4 Tablet together with piroxicam may reduce the effects of Zimpril 4 Tablet in lowering blood pressure, they may also increase the risk of kidney problems.

How to manage the interaction:
Co-administration of Piroxicam with Zimpril 4 Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, breathing difficulty, muscle pain, and irregular heart rhythm, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
PerindoprilLithium
Severe
How does the drug interact with Zimpril 4 Tablet:
Zimpril 4 Tablet when taken together with lithium may significantly increase the blood levels of lithium.

How to manage the interaction:
Although there is drug interaction between Zimpril 4 Tablet and lithium, but can be taken together if advised by a doctor. if experience dizziness, confusion, diarrhea, vomiting, muscle weakness, tremor (shaking of hand & legs) blurred vision, ringing in the ear, excessive thirst, and/or increased urination consult a doctor immediately. Do not discontinue medications without consulting a doctor.
PerindoprilSpironolactone
Severe
How does the drug interact with Zimpril 4 Tablet:
Using Zimpril 4 Tablet together with spironolactone may cause hyperkalemia (high potassium level in blood).

How to manage the interaction:
Although taking spironolactone and Zimpril 4 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as weakness, confusion, numbness or tingling, and uneven heartbeats. Do not stop using any medications without consulting doctor.
PerindoprilLeflunomide
Severe
How does the drug interact with Zimpril 4 Tablet:
Using leflunomide together with Zimpril 4 Tablet can increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Leflunomide and Zimpril 4 Tablet, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms - fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, liver damage or bleeding - make sure to contact your doctor right away. Do not stop using any medications without talking to your doctor.
PerindoprilAllopurinol
Severe
How does the drug interact with Zimpril 4 Tablet:
Co-administration of Allopurinol with Zimpril 4 Tablet may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Allopurinol and Zimpril 4 Tablet, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms, contact your doctor immediately . Do not discontinue any medications without consulting a doctor.
PerindoprilOlmesartan medoxomil
Severe
How does the drug interact with Zimpril 4 Tablet:
Coadministration of Olmesartan medoxomil with Zimpril 4 Tablet may cause low blood pressure, kidney problems, and may increase potassium levels in the blood.

How to manage the interaction:
Although taking olmesartan medoxomil together with Zimpril 4 Tablet may lead to an interaction but can be taken if prescribed by the doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
PerindoprilTeriflunomide
Severe
How does the drug interact with Zimpril 4 Tablet:
Using Teriflunomide together with Zimpril 4 Tablet can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Zimpril 4 Tablet and Teriflunomide, but it can be taken if prescribed by a doctor. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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PERINDOPRIL ERBUMINE-4MGPotassium rich foods
Moderate

Drug-Food Interactions

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PERINDOPRIL ERBUMINE-4MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking Zimpril 4 Tablet with potassium-containing foods can increase the risk of hyperkalemia (high potassium levels in the blood). Avoid moderately high or high potassium dietary intake with Zimpril 4 Tablet, as it can lead to an interaction.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • NITROGLYCERIN
  • ALISKIREN
  • LOSARTAN
  • CANDESARTAN
  • CAPTOPRIL
  • ENALAPRIL
  • PREGABALIN
  • HYDROCHLOROTHIAZIDE
  • FUROSEMIDE
  • BUMETANIDE
  • CHLORTHALIDONE
  • INDAPAMIDE
  • NAPROXEN
  • INDOMETHACIN
  • CELECOXIB
  • CODEINE
  • LITHIUM

Habit Forming

No

Special Advise

  • Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
  • Inform your doctor if you are due to undergo any surgery, LDL apheresis (removal of cholesterol from blood), or desensitisation treatment.
  • Regular kidney function, blood pressure, and electrolyte level monitoring are advised.

Diet & Lifestyle Advise

  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week.
  • Opt for a diet rich in whole grains, fruits, vegetables, and low-fat dairy products.
  • Limit intake of sodium chloride (table salt) in your daily diet.
  • Quitting smoking is the best strategy to lower the risk of heart disease.
  • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Try to include heart-healthy omega 3 fatty acid containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

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