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  3. Farabine 20 mg Injection 20 ml

48 Hrs returnable
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Farabine 20 mg Injection 20 ml, Pack of 1 INJECTION
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Prescription drug

Whats That

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CLOFARABINE-20MG
PARENTERAL
Not Returnable
Apr-24
Prescription drug
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Country of origin

India
Other Info - FAR0122

FAQs

Farabine 20 mg Injection 20 ml contains Clofarabine, which works by inhibiting the DNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells.
Farabine 20 mg Injection 20 ml is used only in children and adolescents 1-21 years. It is not recommended for adults.
Treatment with Farabine 20 mg Injection 20 ml may result in cerebral, gastric, and pulmonary hemorrhage that is severe and fatal. Keep track of platelets and coagulation parameters and treat as needed.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

Avoid consuming alcohol while on treatment with Farabine 20 mg Injection 20 ml as it may cause severe side effects.

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Pregnancy

Unsafe

Farabine 20 mg Injection 20 ml is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are under 21 and pregnant or planning pregnancy, inform your doctor before receiving Farabine 20 mg Injection 20 ml. You should not become pregnant while you are taking Farabine 20 mg Injection 20 ml. Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

There are no data on the presence of clofarabine in human milk, its effects on breastfed children, or its impact on milk supply; due to the possibility of serious adverse events in breastfed children, including genotoxicity, patients are advised not to breastfeed during therapy and for at least two weeks following the final dosage.

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Driving

Not applicable

Farabine 20 mg Injection 20 ml is administered to hospitalized patients.

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Liver

Caution

Farabine 20 mg Injection 20 ml has not been studied in patients with liver impairment. However, inform your doctor if you have liver problems.

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Kidney

Caution

If you have a history of kidney disease or have a pre-existing condition, notify your doctor before getting Farabine 20 mg Injection 20 ml. Based on your situation, your doctor may adjust the dose of this medication or prescribe a suitable alternative. Farabine 20 mg Injection 20 ml has the potential to cause renal toxicity, which presents as high creatinine levels and sudden renal failure. Monitor renal function and adjust or discontinue Clolar as needed.

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Children

Safe if prescribed

Farabine 20 mg Injection 20 ml is recommended for children and adolescents below 21 years of age only if prescribed by the oncologist.

Reference

  1. https://medlineplus.gov/druginfo/meds/a607012.html
  2. https://reference.medscape.com/drug/clolar-clofarabine-342196
  3. https://www.mayoclinic.org/drugs-supplements/clofarabine-intravenous-route/description/drg-20063034
  4. https://www.oncolink.org/cancer-treatment/oncolink-rx/clofarabine-clolar-r
  5. https://www.pediatriconcall.com/drugs/clofarabine/118
  6. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021673s024lbl.pdf

About Farabine 20 mg Injection 20 ml

Farabine 20 mg Injection 20 ml is an anti-cancer medicine used in pediatric patients aged 1 - 21 years for the treatment of acute lymphoblastic leukaemia, a blood cancer that primarily affects the blood and bone marrow. Farabine 20 mg Injection 20 ml is used in patients with relapsed or refractory acute lymphoblastic leukaemia (ALL) after receiving at least two prior therapies.

Farabine 20 mg Injection 20 ml contains Clofarabine as an active ingredient in the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme responsible for DNA elongation, synthesis, and repair.

Farabine 20 mg Injection 20 ml may cause certain side effects, such as skin rash, fatigue, headache, decreased platelet count, nausea, vomiting, diarrhoea, fever, anxiety, flushing, and injection site reactions. These side effects do not require medical attention and gradually resolve over time. A trained oncologist will administer Farabine 20 mg Injection 20 ml. Do not self-administer.

Farabine 20 mg Injection 20 ml should be avoided if you are allergic to it or any other components present in it. It should be used with caution in patients with a pre-existing or history of liver/kidney disease, gastrointestinal disorders, skin problems, and bleeding disorders, as it may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. It is not recommended for use in pregnancy or breastfeeding.

Uses of Farabine 20 mg Injection 20 ml

Acute lymphocytic leukemia (ALL).

Medicinal Benefits Mweb

Medicinal Benefits

Farabine 20 mg Injection 20 ml contains Clofarabine, which is used in the treatment of acute lymphoblastic leukemia (ALL). It works by inhibiting the DNA polymerase enzyme that is responsible for DNA elongation, synthesis, and repair. In general, it inhibits the production of genetic material (DNA) in the cancer cells that are essential for cell growth, repair and multiplication. Thus, Farabine 20 mg Injection 20 ml stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.

Directions for Use

A trained and experienced oncologist will administer Farabine 20 mg Injection 20 ml.

Side Effects of Farabine 20 mg Injection 20 ml

  • Nausea
  • Diarrhoea
  • Fatigue
  • Vomiting
  • Headache
  • Abdominal pain
  • Flusing
  • Skin rash
  • Fever
  • Rash
  • Itching
  • Pain at the site of injection
  • Injection site reactions

Drug Warnings

Farabine 20 mg Injection 20 ml should be avoided if you are allergic to it or any other components present in it. Before receiving, if the child has/had any history of liver/kidney disease, gastrointestinal disorders, skin problems, and bleeding disorders, as it may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Farabine 20 mg Injection 20 ml is given in children above one year of age only if prescribed by the doctor. Farabine 20 mg Injection 20 ml may cause myelosuppression, QT prolongation, hepatotoxicity, renal toxicity, cerebral, gastrointestinal and pulmonary haemorrhage, Tumor Lysis syndrome, severe infections, Systemic Inflammatory Response Syndrome (SIRS), enterocolitis, and skin reactions in some patients. Hence, inform your doctor about your complete medical and medication history before receiving this medicine.

Drug-Drug Interactions

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ClofarabineLeflunomide
Severe
ClofarabineBaricitinib
Severe

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Drug Interactions Checker List

  • ADALIMUMAB
  • NATALIZUMAB
  • INFLIXIMAB
  • EFAVIRENZ
  • HALOPERIDOL

Habit Forming

No

Special Advise

  • A blood test, such as LFT and RFT, should be performed to check for liver/kidney function.
  • Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).
  • It is advised to use contraceptive pills while using Farabine 20 mg Injection 20 ml to prevent pregnancy.

Diet & Lifestyle Advise

  • After beginning your treatment, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.