Cfara Injection

Cfara Injection is an anti-cancer medicine used in pediatric patients aged 1 - 21 years for the treatment of acute lymphoblastic leukaemia, a blood cancer that primarily affects the blood and bone marrow. Cfara Injection is used in patients with relapsed or refractory acute lymphoblastic leukaemia (ALL) after receiving at least two prior therapies.

Cfara Injection contains Clofarabine as an active ingredient in the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme responsible for DNA elongation, synthesis, and repair.

Cfara Injection may cause certain side effects, such as skin rash, fatigue, headache, decreased platelet count, nausea, vomiting, diarrhoea, fever, anxiety, flushing, and injection site reactions. These side effects do not require medical attention and gradually resolve over time. A trained oncologist will administer Cfara Injection. Do not self-administer.

Cfara Injection should be avoided if you are allergic to it or any other components present in it. It should be used with caution in patients with a pre-existing or history of liver/kidney disease, gastrointestinal disorders, skin problems, and bleeding disorders, as it may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. It is not recommended for use in pregnancy or breastfeeding.

Cfara Injection contains Clofarabine, which is used in the treatment of acute lymphoblastic leukemia (ALL). It works by inhibiting the DNA polymerase enzyme that is responsible for DNA elongation, synthesis, and repair. In general, it inhibits the production of genetic material (DNA) in the cancer cells that are essential for cell growth, repair and multiplication. Thus, Cfara Injection stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.

Cfara Injection should be avoided if you are allergic to it or any other components present in it. Before receiving, if the child has/had any history of liver/kidney disease, gastrointestinal disorders, skin problems, and bleeding disorders, as it may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Cfara Injection is given in children above one year of age only if prescribed by the doctor. Cfara Injection may cause myelosuppression, QT prolongation, hepatotoxicity, renal toxicity, cerebral, gastrointestinal and pulmonary haemorrhage, Tumor Lysis syndrome, severe infections, Systemic Inflammatory Response Syndrome (SIRS), enterocolitis, and skin reactions in some patients. Hence, inform your doctor about your complete medical and medication history before receiving this medicine.

• A blood test, such as LFT and RFT, should be performed to check for liver/kidney function.
• Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).
• It is advised to use contraceptive pills while using Cfara Injection to prevent pregnancy.