Denbri Injection 1 ml

Denbri Injection 1 ml belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. Denbri Injection 1 ml is also used to treat bone loss due to reduced testosterone level caused by surgery, due to the treatment with medicines such as glucocorticoids and in patients with prostate cancer. Denbri Injection 1 ml may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumour of the bone, and to treat high calcium levels caused due to cancer.
 
Denbri Injection 1 ml contains ‘denosumab’, which works by blocking a receptor in the body that causes bone loss, thereby treats bone loss. Denbri Injection 1 ml treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slowing the tumour growth. Denbri Injection 1 ml helps treat high calcium levels by decreasing bone breakdown as a breakdown of the bones releases calcium. Denbri Injection 1 ml makes the bones stronger and less likely to break.
 
Denbri Injection 1 ml will be administered by a healthcare professional; do not self-administer. In some cases, you may experience common side-effects such as bone/joint/muscle pain, arm/leg pain, abdominal discomfort, constipation, and painful/frequent urination. You are advised to talk to your doctor if the side effects persist or worsen.
 
Denbri Injection 1 ml might cause osteonecrosis of the jaw; therefore, maintain good dental hygiene and receive regular dental check-ups whilst on treatment with Denbri Injection 1 ml. Avoid taking Denbri Injection 1 ml if you are pregnant. Consult your doctor before taking Denbri Injection 1 ml if you are breastfeeding. Denbri Injection 1 ml is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any interactions.

Denbri Injection 1 ml belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. Denbri Injection 1 ml is also used to treat bone loss due to reduced hormone levels caused by surgery or due to treatment with medicines in patients with prostate cancer. It is also used to treat bone loss occurring due to long-term treatment with glucocorticoids in patients who are at an increased risk of fractures. Denbri Injection 1 ml may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumours of the bone and to treat high calcium levels caused due to cancer. Denbri Injection 1 ml binds to a protein on RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. Thereby decreases bone breakdown, increases bone density, and strengthens the bone. Denbri Injection 1 ml treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slows the tumour growth. Denbri Injection 1 ml helps treat high calcium levels by decreasing bone breakdown as the breakdown of the bones releases calcium. Denbri Injection 1 ml makes the bones stronger and less likely to break.

• Bone/joint/muscle pain
• Pain in extremities (arm/leg pain)
• Abdominal discomfort
• Constipation
• Painful/frequent urination
• Upper respiratory tract infection
• Rash
• Eczema
• Hair loss

Do not take Denbri Injection 1 ml if you are allergic to any of its components; if you have hypocalcaemia (low levels of calcium in the blood). Inform your doctor if you have low levels of calcium, kidney dysfunction, liver problems, poor dental health, gum problems, weak immune system, hypoparathyroidism (decreased function of the parathyroid gland), malabsorption, latex allergy, undergone thyroid surgery, planned dental procedure, if you are taking glucocorticoids, or cannot take calcium and vitamin D supplements. Avoid taking Denbri Injection 1 ml if you are pregnant. Consult your doctor if you are breastfeeding. Denbri Injection 1 ml is not recommended for children below 18 years as safety and effectiveness have not been established.

• PALBOCICLIB

• If you are a woman of child-bearing potential, use effective contraception during the treatment with Denbri Injection 1 ml and for 5 months after discontinuation. 
• Your doctor might prescribe calcium and vitamin D supplements whilst on treatment with Denbri Injection 1 ml.

• Include dairy products like milk, yoghurt, cheese, or milk-based custard in your diet.
• Eat daily a serving of broccoli, cabbage, bok choy (Chinese white cabbage), spinach, and other green leafy vegetables.
• Snack on calcium-rich nuts like Brazil nuts or almonds.
• Sprinkle sesame seeds over your food, vegetables, and salads. Sesame seeds are high in calcium.
• Avoid or reduce the intake of caffeine, soft drinks, and alcohol as they may inhibit calcium absorption.
• Replace the meat with tofu or tempeh for extra calcium in your food.