Nicran Injection 2 ml belongs to a group of medicines called gastrointestinal agents. It is used to treat and prevent stomach ulcers, indigestion, heartburn, acid reflux, gastro-oesophageal reflux disease (GORD), and indigestion. It works by decreasing the amount of acid in the stomach.

Nicran Injection 2 ml contains Ranitidine, a histamine-2 (H2) receptor blocker that helps reduce stomach acid by blocking the actions of the H2 receptor. The H2 receptor lies in the parietal cells of the stomach wall, and it is responsible for gastric acid secretion. Excessive gastric acid secretion damages the tissues in the food pipe, stomach, and duodenum.

Nicran Injection 2 ml is administered by a healthcare professional; do not self-administer. Nicran Injection 2 ml shows some common side effects like headache, diarrhoea, stomach ache or abdominal pain, constipation, and feeling sick. These side effects are temporary and may get resolved after some time. However, if these side effects persist, contact your doctor.

Before receiving the Nicran Injection 2 ml, notify your doctor if you are allergic to any medications or foods. If you are pregnant or suspect you may be pregnant, or if you are a nursing mother, please notify your doctor. Also, before receiving the Nicran Injection 2 ml, inform your doctor if you have or have had kidney, liver, heart, lung, poor immune system, diabetes, stomach cancer, or porphyria (hereditary disease).

Nicran Injection 2 ml helps in reducing the excess amount of stomach acid. In turn, it prevents the formation of an ulcer in the stomach (peptic ulcer) and effectively treats or alleviates the various medical illness associated with this, including peptic ulcer, indigestion, dyspepsia, and heartburn. Besides this, it also stops acid from coming up from the stomach while under anaesthetic during an operation.

• Headache
• Diarrhoea
• Stomach ache or abdominal pain
• Constipation
• Feeling sick

Inform your doctor about allergic or hypersensitive reactions to medications or food before receiving the Nicran Injection 2 ml. Inform your doctor if you are pregnant or suspect you may be pregnant or if you are a nursing mother. Also, inform your doctor before receiving the Nicran Injection 2 ml if you have or have had a history of kidney, liver, heart, lung, poor immune system, diabetes, stomach cancer, or porphyria (hereditary disease). Keep your doctor informed about your health condition and all the medicines you take before taking Nicran Injection 2 ml to rule out any side effects.

Drug-Drug Interactions: Nicran Injection 2 ml interacts with a blood thinner (e.g. warfarin), antidiabetic medication (e.g. glipizide), a local anaesthetic (e.g. lidocaine), medicines used for heart conditions (e.g. propranolol, procainamide), antianxiety medications (e.g. diazepam), antiepilepsy medications (e.g. phenytoin), asthma medications (e.g. theophylline), HIV medications (e.g. atazanavir), medicines used for sleep problems (e.g. triazolam), medicines used for lung cancer (e.g. gefitinib), antifungal infections (e.g. ketoconazole), and medicines to help with sleeping problems (e.g. midazolam, triazolam).

Drug-Food Interactions: Consumption of alcohol and nicotine (tobacco) should be avoided.

Drug-Disease Interactions: Nicran Injection 2 ml interacts with disease conditions, including kidney, liver, heart, lung, poor immune system, diabetes, stomach cancer, or porphyria (hereditary disease), and unintentional weight loss associated with acid indigestion.

• WARFARIN
• GLIPIZIDE
• LIDOCAINE
• PROPRANOLOL
• PROCAINAMIDE
• DIAZEPAM
• PHENYTOIN
• THEOPHYLLINE
• ATAZANAVIR
• TRIAZOLAM
• GEFITINIB
• KETOCONAZOLE
• MIDAZOLAM

• Avoid acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.
• Before going to sleep, raise your bedhead, so your head and chest are higher than your feet. Do not use piles of pillows; one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.
• Avoid taking alcohol and smoking cigarettes. Alcohol can raise the production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), preventing stomach acid backflow into the food pipe.
• Include high fibre-containing foods, berries, cherries, leafy green veggies (kale, spinach) and black peppers in your meal.
• Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help prevent excess stomach acid production. Cranberry juice can be beneficial for peptic ulcers and H Pyroli infections.
• Avoid regular sitting continuously, as it can increase stomach acid production. Take a break of 5 minutes in 1 hour by brisk walking or stretching.

Peptic ulcers: Peptic ulcers are sores that develop on the stomach and intestine lining due to erosion of the stomach's protective lining. Symptoms include nausea, appetite changes, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.

Dyspepsia (indigestion): Indigestion is the feeling of fullness. It occurs due to slow gastric emptying. Symptoms include stomach pain, bloating, heartburn, nausea and vomiting.

Heartburn: Heartburn is a burning sensation in the chest caused by stomach acid rising to the oesophagus (acid reflux). If this occurs repeatedly, the condition is known as gastroesophageal reflux disease (GERD).