ZOLDONAT 4MG INJECTION

ZOLDONAT 4MG INJECTION belongs to the class of medicines called 'bisphosphonates' used to treat osteoporosis (weak and brittle bones) caused by menopause or long-term steroid use. ZOLDONAT 4MG INJECTION also treats Paget’s bone and high calcium levels caused by cancer. Osteoporosis is a bone disease that weakens and thins bones by decreasing bone density, common in post-menopausal women.  As the density of bones decreases, they weaken and are more likely to break. 

ZOLDONAT 4MG INJECTION contains Zoledronic acid that works by binding to the bone tightly and preventing the removal of calcium by osteoclasts (a type of bone cell that destroys bone tissue). This prevents osteoclasts from breaking down the bone and keeps the bones strong and minimizes the risk of bones breaking.

A doctor or nurse will administer ZOLDONAT 4MG INJECTION. In some cases, you may experience headache, fever, nausea, dizziness, vomiting, back pain, diarrhea, pain in the muscles, joints, or bones, swelling, or pain at the infusion site. Most of these side effects of ZOLDONAT 4MG INJECTION do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to ZOLDONAT 4MG INJECTION or any other medicines, please tell your doctor. Avoid taking ZOLDONAT 4MG INJECTION if you are pregnant or breastfeeding and consult a doctor. ZOLDONAT 4MG INJECTION is not recommended for children below 18 years as the safety and effectiveness were not established. Avoid taking ZOLDONAT 4MG INJECTION if you have hypocalcemia (low calcium levels in the blood) and severe kidney problems. Drive only if you are alert as ZOLDONAT 4MG INJECTION may cause dizziness. ZOLDONAT 4MG INJECTION may cause osteonecrosis of the jaw (ONJ) in some patients. Therefore, if you experience any problems with teeth or mouth such as loose teeth, swelling or pain, non-healing of sores, or discharge, consult your doctor and dentist as these might be signs of osteonecrosis of the jaw.

ZOLDONAT 4MG INJECTION contains Zoledronic acid used to treat postmenopausal osteoporosis, Paget’s disease, and hypercalcemia of malignancy (bone cancer in which excess of calcium exits). ZOLDONAT 4MG INJECTION binds to the bone tightly and prevents calcium removal by osteoclasts (a type of bone cell that destroy bone tissue). This prevents osteoclasts from breaking down the bone, strengthening bones, and minimizing the risk of bones breaking. Also, ZOLDONAT 4MG INJECTION may reduce calcium levels in the blood by preventing calcium reabsorption from bones to the blood. Thus, it helps in treating high calcium levels in the blood caused by cancer.

• Headache
• Fever
• Nausea
• Dizziness
• Vomiting
• Back pain
• Diarrhoea
• Flu-like symptoms (chills, tiredness, muscle, and joint pain)
• Pain in the muscles, joints, or bones
• Swelling or pain at the infusion site

If you are allergic to ZOLDONAT 4MG INJECTION or any other medicines, please tell your doctor. Avoid taking ZOLDONAT 4MG INJECTION if you are pregnant or breastfeeding and consult a doctor. ZOLDONAT 4MG INJECTION is not recommended for children below 18 years as the safety and effectiveness were not established. Avoid taking ZOLDONAT 4MG INJECTION if you have hypocalcemia (low calcium levels in the blood) and severe kidney problems. Drive only if you are alert as ZOLDONAT 4MG INJECTION may cause dizziness. If you are not able to take daily calcium supplements, have had sections of the intestine or some or all of the parathyroid glands in the neck surgically removed, have cancer, gum disease, poor dental health, or planned tooth extraction or kidney problem, inform your doctor before taking ZOLDONAT 4MG INJECTION. If you are a smoker, inform your doctor before receiving ZOLDONAT 4MG INJECTION as it may increase the risk of dental problems. ZOLDONAT 4MG INJECTION may cause osteonecrosis of the jaw (ONJ) in some patients. Therefore, if you experience any problems with teeth or mouth such as loose teeth, swelling or pain, non-healing of sores, or discharge, consult your doctor and dentist as these might be signs of osteonecrosis of the jaw. You are recommended to drink at least 2 glasses of fluids before and after treatment with ZOLDONAT 4MG INJECTION as advised by your doctor to prevent dehydration. Take calcium and vitamin D supplements as prescribed by your doctor as ZOLDONAT 4MG INJECTION may reduce calcium levels in the blood.

• GENTAMICIN
• FUROSEMIDE

• A preventive dental check-up is required before using ZOLDONAT 4MG INJECTION as it has been reported to cause osteonecrosis of the jaw. 
• A blood test is recommended before taking each dose of ZOLDONAT 4MG INJECTION to monitor kidney functioning. 
• Regular intake of calcium and vitamin D may be recommended by your doctor while taking treatment with ZOLDONAT 4MG INJECTION. 
• While using ZOLDONAT 4MG INJECTION, you may experience musculoskeletal pain, in this case, stop taking ZOLDONAT 4MG INJECTION and consult a doctor. 

• Include dairy products like milk, yoghurt, cheese, or milk-based custard in your diet.
• Eat daily a serving of broccoli, cabbage, bok choy (Chinese white cabbage), spinach, and other green leafy vegetables.
• Snack on calcium-rich nuts like Brazil nuts or almonds.
• Sprinkle sesame seeds over your food, vegetables, and salads. Sesame seeds are high in calcium.
• Avoid or reduce the intake of caffeine, soft drinks, and alcohol that inhibit calcium absorption.
• Replace the meat with tofu or tempeh for extra calcium in your food.