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  1. Home
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  3. Trexomune 10 Tablet

Prescription drug
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

Composition :

METHOTREXATE-10MG

Manufacturer/Marketer :

Zeelab Pharmacy Pvt Ltd

Consume Type :

Oral

Return Policy :

Not Returnable

Therapeutic Class

[IMMUNOSUPPRESSANTS, ANTIMETABOLITES]
Other Info - TREX767

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jul 8, 2025 | 9:30 AM IST

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Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Safe if prescribed

You are recommended to avoid alcohol consumption while taking Trexomune 10 Tablet.

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Pregnancy

Consult your doctor

Trexomune 10 Tablet may cause serious birth defects. It is not recommended to take Trexomune 10 Tablet while you are pregnant.

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Breast Feeding

Consult your doctor

Trexomune 10 Tablet passes into breast milk. Avoid breastfeeding whilst on treatment with Trexomune 10 Tablet.

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Driving

Safe if prescribed

Trexomune 10 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you experience these symptoms.

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Liver

Consult your doctor

Do not take Trexomune 10 Tablet if you have chronic liver disease. Please consult your doctor if you have liver impairment before taking Trexomune 10 Tablet.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment before taking Trexomune 10 Tablet.

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Children

Safe if prescribed

Trexomune 10 Tablet should be used with caution in children and only if prescribed by the doctor.

Product Substitutes

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/011719s117lbl.pdf
  2. http://www.hpra.ie/img/uploaded/swedocuments/pil-2167015-11052016181932-635985875740562500.pdf
  3. https://www.cipla.com/sites/default/files/Methotrexate%202.5%20mg%20%E2%80%93%20Patient%20Card%20-%20Risk%20Minimisation%20Information%20for%20Patients.pdf
  4. https://www.stmarkshospital.nhs.uk/wp-content/uploads/2014/07/IBD_methotrexate_leaflet.pdf
  5. https://www.drugs.com/methotrexate.html
  6. https://medlineplus.gov/druginfo/meds/a682019.html

About Trexomune 10 Tablet

Trexomune 10 Tablet belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis, severe psoriasis, and severe psoriatic arthritis. Trexomune 10 Tablet is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

Trexomune 10 Tablet contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Trexomune 10 Tablet prevents and stops the growth of cancer cells, thereby helps treat cancer. Trexomune 10 Tablet treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

In some cases, Trexomune 10 Tablet may cause common side-effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, leukopenia (decreased number of white blood cells), and soreness of mouth and lips. You are advised to talk to your doctor if you experience these side effects persistently.

Take Trexomune 10 Tablet exactly as prescribed by the doctor; daily intake of Trexomune 10 Tablet could lead to serious toxic effects. Do not take Trexomune 10 Tablet if you are pregnant or breastfeeding. Trexomune 10 Tablet may cause dizziness and fatigue, so drive only if you are alert. Avoid consuming alcohol whilst on treatment with Trexomune 10 Tablet. Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Inform your doctor about your medications and health condition to rule out any unpleasant side effects/interactions.

Uses of Trexomune 10 Tablet

Rheumatoid arthritis, Psoriatic arthritis, Psoriasis, Cancer

Medicinal Benefits Mweb

Key Benefits

Trexomune 10 Tablet belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis (arthritis in children), severe psoriasis, and severe psoriatic arthritis. Trexomune 10 Tablet helps treat rheumatoid arthritis and psoriatic arthritis by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Trexomune 10 Tablet treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis. Trexomune 10 Tablet is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system). Trexomune 10 Tablet prevents and stops the growth of cancer cells by interfering with DNA production. Trexomune 10 Tablet may also be used to treat inflammatory bowel disease.

Directions for Use

Trexomune 10 Tablet should be taken exactly as prescribed by the doctor. Tablet/capsule: Take it one hour after food in the evening or as advised by the doctor. Swallow the tablet/capsule as a whole with a glass of water whilst standing or sitting upright; do not break or chew it. Oral solution: Take the prescribed quantity by mouth using the dosing syringe.

Side Effects of Trexomune 10 Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Unusual fatigue
  • Dizziness
  • Headache
  • Loss of appetite
  • Elevated liver enzymes
  • Lowered resistance to infections
  • Tingling sensation
  • Leukopenia (decreased number of white blood cells)
  • Soreness of mouth and lips

Drug Warnings

Do not take Trexomune 10 Tablet if you are allergic to any of its contents; if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, chronic liver disease; if you are pregnant or breastfeeding. Talk to your doctor before taking Trexomune 10 Tablet if you have/had liver or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if you are due to have any vaccinations, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs. Trexomune 10 Tablet may cause dizziness and fatigue, so drive only if you are alert. Take Trexomune 10 Tablet exactly as directed by the doctor as it may cause serious problems if not taken in the dose and duration prescribed by the doctor. Stop taking Trexomune 10 Tablet and consult your doctor immediately if you have mouth sores, diarrhoea, a fever, dehydration, cough, bleeding, shortness of breath, any signs of infection, or a skin rash.

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
MethotrexateCloxacillin
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Trexomune 10 Tablet:
Co-administration of Etretinate with Trexomune 10 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Trexomune 10 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateCloxacillin
Severe
How does the drug interact with Trexomune 10 Tablet:
Co-administration of Trexomune 10 Tablet with cloxacillin can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between cloxacillin and Trexomune 10 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, Consult a doctor. Do not stop using any medications without consulting to a doctor.
MethotrexatePhenylbutazone
Severe
How does the drug interact with Trexomune 10 Tablet:
Coadministration of phenylbutazone with Trexomune 10 Tablet may increase the levels and side effects of phenylbutazone.

How to manage the interaction:
Although there is a possible interaction between phenylbutazone and Trexomune 10 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateDiclofenac
Severe
How does the drug interact with Trexomune 10 Tablet:
Co-administration of Trexomune 10 Tablet with diclofenac can increase the levels and effects of Trexomune 10 Tablet. This can lead to increased risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Trexomune 10 Tablet and diclofenac, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, loss of hunger, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, fits, infection, fever, chills, body aches, sore throat or muscle weakness, consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateMefenamic acid
Severe
How does the drug interact with Trexomune 10 Tablet:
Coadministration of Mefenamic acid with Trexomune 10 Tablet may increase the blood levels and side effects of Trexomune 10 Tablet.

How to manage the interaction:
Although there is a possible interaction between mefenamic acid and Trexomune 10 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, breathing difficulty, a dry cough, dizziness or fainting, unusual bruising or bleeding, seizures(fits), mouth sores or ulcers, infection, as well as flu-like symptoms(fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexatePiroxicam
Severe
How does the drug interact with Trexomune 10 Tablet:
Coadministration of Trexomune 10 Tablet with piroxicam can increase the levels and side effects.

How to manage the interaction:
Although there is a possible interaction between piroxicam and Trexomune 10 Tablet, it can be taken if prescribed by a doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateTenofovir alafenamide
Severe
How does the drug interact with Trexomune 10 Tablet:
Combine use of tenofovir alafenamide with Trexomune 10 Tablet may increase the levels or side effects of tenofovir alafenamide.

How to manage the interaction:
Although there is a possible interaction between tenofovir alafenamide and Trexomune 10 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting your doctor.
MethotrexateAcitretin
Severe
How does the drug interact with Trexomune 10 Tablet:
Co-administration of Acitretin with Trexomune 10 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Although there is a possible interaction between Acitretin with Trexomune 10 Tablet, you can take these medicines together if only when prescribed by a doctor. Do not discontinue any medications without talking to a doctor.
MethotrexateNaproxen
Severe
How does the drug interact with Trexomune 10 Tablet:
Coadministration of Trexomune 10 Tablet with Naproxen can increase the levels and side effects of Trexomune 10 Tablet.

How to manage the interaction:
Taking Trexomune 10 Tablet with Naproxen together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateHuman immunoglobulin
Severe
How does the drug interact with Trexomune 10 Tablet:
Taking Human immunoglobulin with Trexomune 10 Tablet may increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Human immunoglobulin with Trexomune 10 Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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METHOTREXATE-10MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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METHOTREXATE-10MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Caffeine may reduce the effectiveness of Trexomune 10 Tablet. Avoid taking caffeine while taking Trexomune 10 Tablet. This can increase the risk or severity of side effects.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CELECOXIB
  • ACETAMINOPHEN
  • HYDROCODONE
  • DULOXETINE
  • ETANERCEPT
  • ADALIMUMAB
  • ESOMEPRAZOLE
  • HYDROXYCHLOROQUINE

Habit Forming

No

Special Advise

  • Women of child-bearing age must use effective contraception whilst on treatment with Trexomune 10 Tablet and for at least 6 months after the last dose.
  • Male patients are advised to consult their doctor regarding the possibility of sperm preservation before starting the treatment as Trexomune 10 Tablet may cause infertility.
  • Trexomune 10 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
  • Your doctor may advise regular blood tests, kidney and liver tests to monitor your condition.
  • If you miss a dose of Trexomune 10 Tablet, call your doctor and ask if you should take the missed dose or not.

Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

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