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  1. Home
  2. Medicine

  3. Sentibrim-BZ Ophthalmic Suspension 5 ml

Prescription drug
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sureshvarma D , MPharma

Composition :

BRIMONIDINE-2MG + BRINZOLAMIDE-10MG

Manufacturer/Marketer :

Sentiss Pharma Pvt Ltd

Consume Type :

OPHTHALMIC

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIGLAUCOMA AGENTS

Country of origin

INDIA

Manufacturer/Marketer address

3Rd Floor, 261, Udyog Vihar Phase- Iv, Gurgaon, Haryana 122001, India
Other Info - SEN0383

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Sureshvarma D

Reviewed By

Sureshvarma D

MPharma

Last Updated

Jul 8, 2025 | 9:40 AM IST

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Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Avoid consuming alcohol while using Sentibrim-BZ Ophthalmic Suspension 5 ml as it might cause increased dizziness and drowsiness. Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Sentibrim-BZ Ophthalmic Suspension 5 ml belongs to pregnancy category C. Use effective contraception while using Sentibrim-BZ Ophthalmic Suspension 5 ml. Avoid using Sentibrim-BZ Ophthalmic Suspension 5 ml during pregnancy unless clearly indicated by the doctor. Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Sentibrim-BZ Ophthalmic Suspension 5 ml might pass into breastmilk. Avoid breastfeeding while using Sentibrim-BZ Ophthalmic Suspension 5 ml.

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Driving

Unsafe

Sentibrim-BZ Ophthalmic Suspension 5 ml might cause dizziness, drowsiness, and blurred/abnormal vision. So, avoid driving or operating machinery until your vision is clear.

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Liver

Caution

Please consult your doctor if you have any concerns regarding the usage of Sentibrim-BZ Ophthalmic Suspension 5 ml in patients with liver impairment.

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Kidney

Caution

Please consult your doctor if you have any concerns regarding the usage of Sentibrim-BZ Ophthalmic Suspension 5 ml in patients with kidney impairment. Sentibrim-BZ Ophthalmic Suspension 5 ml is not recommended for patients with severe kidney disease.

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Children

Unsafe

Sentibrim-BZ Ophthalmic Suspension 5 ml is not recommended for children below 18years as the safety and effectiveness have not been established.

Product Substitutes

Reference

  1. https://www.medicines.org.uk/emc/files/pil.3290.pdf
  2. https://www.ema.europa.eu/en/documents/product-information/simbrinza-epar-product-information_en.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/204251s000lbl.pdf
  4. https://www.drugs.com/mtm/brimonidine-and-brinzolamide-ophthalmic.html

About Sentibrim-BZ Ophthalmic Suspension 5 ml

Sentibrim-BZ Ophthalmic Suspension 5 ml is indicated for lowering high intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Glaucoma is an eye disease that causes damage to the optic nerve and results in reduced vision. Ocular hypertension is increased pressure in the eye due to poor drainage of aqueous humour (fluid in the eye that maintains normal pressure by its continuous flow). 
 
Sentibrim-BZ Ophthalmic Suspension 5 ml is a combination of two drugs, namely: Brinzolamide (carbonic anhydrase inhibitor) and Brimonidine (alpha-2 adrenergic receptor agonist). Sentibrim-BZ Ophthalmic Suspension 5 ml decreases the production of aqueous humour, thereby helps lower the increased pressure in the eye. 
 
In some cases, you may experience certain common side effects such as blurred vision, eye redness, discomfort, drowsiness and bad taste in the mouth. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult a doctor if you are pregnant or breastfeeding. Sentibrim-BZ Ophthalmic Suspension 5 ml is not recommended for children below 18 years as the safety and effectiveness have not been established. Sentibrim-BZ Ophthalmic Suspension 5 ml might cause dizziness, drowsiness, and abnormal/blurred vision; so, drive only if you have clear vision. Avoid touching the tip of the dropper as it may contaminate the contents. 

Uses of Sentibrim-BZ Ophthalmic Suspension 5 ml

Open-angle glaucoma or ocular hypertension

Medicinal Benefits Mweb

Medicinal Benefits

Sentibrim-BZ Ophthalmic Suspension 5 ml is a combination of two drugs, namely: Brinzolamide (carbonic anhydrase inhibitors) and Brimonidine (alpha-2 adrenergic receptor agonists). Sentibrim-BZ Ophthalmic Suspension 5 ml is indicated for lowering high intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Sentibrim-BZ Ophthalmic Suspension 5 ml decreases the production of aqueous humour, thereby helps lower the increased pressure in the eye. 

Directions for Use

Lie down and tilt your head backwards. Pull your lower eyelid gently with your index finger to form a pocket. Instil the number of drops advised by the doctor into the pocket of the lower eyelid. Close your eyes for 1-2 minutes.

Side Effects of Sentibrim-BZ Ophthalmic Suspension 5 ml

  • Blurred/abnormal vision
  • Eye redness
  • Eye discomfort
  • Drowsiness
  • Bad taste in the mouth 
  • Dry mouth
  • Dizziness
  • Eye surface inflammation
  • Eye pain

Drug Warnings

Do not take Sentibrim-BZ Ophthalmic Suspension 5 ml if you are allergic to any of its components, if you are taking monoamine oxidase inhibitors, antidepressants, if you have severe kidney problems or excess acidity in the blood. Inform your doctor if you have liver problems, narrow-angle glaucoma, dry eyes, cornea problems, coronary heart disease, depression, poor or disturbed blood circulation. Consult a doctor before using Sentibrim-BZ Ophthalmic Suspension 5 ml if you are pregnant or breastfeeding. Sentibrim-BZ Ophthalmic Suspension 5 ml is not recommended for children below 18 years as safety and effectiveness have not been established. Sentibrim-BZ Ophthalmic Suspension 5 ml might cause dizziness, drowsiness, abnormal/blurred vision; so, drive only if you are alert.

Drug-Drug Interactions

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BrinzolamideCholine salicylate
Severe
BrinzolamideSodium salicylate
Severe

Drug-Drug Interactions

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BrinzolamideCholine salicylate
Severe
How does the drug interact with Sentibrim-BZ Ophthalmic Suspension 5 ml:
Taking Sentibrim-BZ Ophthalmic Suspension 5 ml with Choline salicylate may increase the risk of side effects.

How to manage the interaction:
Although taking Sentibrim-BZ Ophthalmic Suspension 5 ml and Choline salicylate together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience ringing in your ears, headache, vomiting, dizziness, or palpitations, consult a doctor. Do not stop using any medications without consulting a doctor.
BrinzolamideSodium salicylate
Severe
How does the drug interact with Sentibrim-BZ Ophthalmic Suspension 5 ml:
Concomitant use of Sentibrim-BZ Ophthalmic Suspension 5 ml with sodium salicylate may cause ringing in the ears, nausea, vomiting, headache, dizziness, confusion, hallucinations, rapid breathing, fever, and seizure (convulsions).

How to manage the interaction:
Although there is an interaction, Sentibrim-BZ Ophthalmic Suspension 5 ml should be used with sodium salicylate only if prescribed by the doctor. However, if you experience ringing in the ears, vomiting, headache, dizziness, or fever, contact your doctor immediately. Do not stop using any medications without consulting your doctor.
BrinzolamideSalsalate
Severe
How does the drug interact with Sentibrim-BZ Ophthalmic Suspension 5 ml:
Concomitant use of Sentibrim-BZ Ophthalmic Suspension 5 ml with salsalate can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction, Sentibrim-BZ Ophthalmic Suspension 5 ml should be used with salsalate only if prescribed by the doctor. Consult a doctor immediately if you experience ringing in the ears, vomiting, headache, dizziness, and fever. Do not stop using any medications without first talking to your doctor.
BrinzolamideDiflunisal
Severe
How does the drug interact with Sentibrim-BZ Ophthalmic Suspension 5 ml:
Coadministration of Sentibrim-BZ Ophthalmic Suspension 5 ml with diflunisal can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction, Sentibrim-BZ Ophthalmic Suspension 5 ml should be used with diflunisal only if prescribed by the doctor. Consult a doctor if you experience vomiting, headache, dizziness, or fever. Do not stop using any medications without first talking to your doctor.
BrinzolamideAspirin
Severe
How does the drug interact with Sentibrim-BZ Ophthalmic Suspension 5 ml:
Coadministration of Sentibrim-BZ Ophthalmic Suspension 5 ml with Aspirin may cause side effects.

How to manage the interaction:
Although there is a possible interaction between aspirin and Sentibrim-BZ Ophthalmic Suspension 5 ml, you can take these medicines together if prescribed by a doctor. However, if you experience ringing in your ears, headache, vomiting, dizziness, or palpitations, please contact a doctor. Do not stop using any medications without talking to a doctor.
BrimonidineBrivaracetam
Moderate
How does the drug interact with Sentibrim-BZ Ophthalmic Suspension 5 ml:
Sentibrim-BZ Ophthalmic Suspension 5 ml may be absorbed into the bloodstream and occasionally produce central nervous system side effects such as dizziness, drowsiness, and difficulty concentrating. Concomitant use of brivaracetam with Sentibrim-BZ Ophthalmic Suspension 5 ml may increase the risk of these side effects.

How to manage the interaction:
Although there is an interaction brivaracetam can be taken with Sentibrim-BZ Ophthalmic Suspension 5 ml if prescribed by the doctor. Consult the prescriber if you notice dizziness, drowsiness, and difficulty concentrating.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • DIGOXIN
  • ACETAZOLAMIDE
  • METHAZOLAMIDE
  • DORZOLAMIDE
  • CHLORPROMAZINE
  • RESERPINE

Habit Forming

No

Diet & Lifestyle Advise

  • Include fresh fruits and vegetables in your diet.
  • Avoid smoking and alcohol consumption.
  • Avoid intake of baked foods such as cakes, cookies, doughnuts or fried items such as French fries and stick margarine as these foods may worsen glaucoma and damage the optic nerve.
  • Cut down your coffee intake as it may increase pressure in the eye. Replace coffee with green tea.
  • Avoid exercises such as any position where the head is lower than the body, like an inverted yoga pose, as it may increase pressure in the eye. Doing selective exercises is advised for glaucoma patients.

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