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48 Hrs returnable
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Composition :

GLIMEPIRIDE-0.5MG

Manufacturer/Marketer :

Sanofi India Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Apr-24

Therapeutic Class

ANTIDIABETICS AND ANTIHYPERGLYCEMICS

Country of origin

India

Manufacturer/Marketer address

Sanofi House, CTS No.117-B, L&T Business Park, Saki Vihar Road, Powai, Mumbai 400072
Other Info - SEM0056

Author Details

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FAQs

The Semi-Amaryl Tablet 30's contains Glimepiride which acts on insulin-secreting cells called beta cells inside the pancreas and activates calcium channels on cells which lets insulin pass out of the cell. This insulin then makes each cell in the body take up glucose and utilize it, thus lowering raised blood glucose. Therefore, it prevents symptoms of type 2 diabetes.
A patient is advised to take the missed dose as soon as possible or skip to the next dose if it's been too late. A patient should never attempt to take a double dose to compensate for the missed dose as it may prove harmful.
Semi-Amaryl Tablet 30's is not recommended with warfarin as these two drugs are contraindicated with each other and hence may result in any harmful symptom when taken together in heart patients.
Avoid intake of Semi-Amaryl Tablet 30's and consult a doctor if you have an allergy to sulfa drugs, diabetic ketoacidosis, heart disease, liver or kidney disease, an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).
Your blood sugar might get decreased, so regular blood glucose monitoring is required. Signs and symptoms of low blood sugar level are feeling very hungry, dizziness, irritability, confusion, anxiety or shakiness. Try to eat or drink a fast-acting sugar source (like fruit juice, hard candy, crackers, raisins or non-diet soda).
No, Semi-Amaryl Tablet 30's is only prescribed to treat type 2 diabetes and not type 1 diabetes. If you are type 1 diabetic patient consult with a doctor so that insulin forms can be prescribed for the same.
The patient is advised to talk to a doctor before taking contraceptive pills if he/she is already taking Semi-Amaryl Tablet 30's, then the doctor may change the dose of Semi-Amaryl Tablet 30's. This is because oral contraceptive pills change body responds to the sugar.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Not recommended to take Semi-Amaryl Tablet 30's with alcohol. Alcohol intake may increase or decrease the blood sugar lowering action of Semi-Amaryl Tablet 30's in an unpredictable way resulting in a harmful event.

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Pregnancy

Caution

Semi-Amaryl Tablet 30's is a pregnancy Category C medicine which means that there are no well-controlled studies that have been done in pregnant women. However, if you are taking Semi-Amaryl Tablet 30's during pregnancy, stop taking it at least 2 weeks before your due date or as prescribed by your doctor.

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Breast Feeding

Caution

Not recommended to be taken by breastfeeding mothers. Semi-Amaryl Tablet 30's may pass into breast milk and may cause the risk of low blood sugar in the infant. Consult your doctor for further advice.

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Driving

Caution

Not recommended in patients with fluctuating glucose levels. Semi-Amaryl Tablet 30's can reduce the ability to concentrate or react, if your blood sugar is lowered (hypoglycemia) or raised (hyperglycemia) or if you develop visual problems as a result of such conditions. Thus not recommended as the patient can endanger himself or others (e.g. when driving a car or using machines).

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Liver

Caution

Not recommended in patients with liver dysfunction. A patient should consult a doctor before taking Semi-Amaryl Tablet 30's as it may cause liver damage.

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Kidney

Caution

Not recommended in patients with kidney dysfunction. A patient should consult a doctor before taking Semi-Amaryl Tablet 30's as it may cause kidney damage.

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Children

Unsafe

Semi-Amaryl Tablet 30's is not approved for use by a person less than 18 years old.

About Semi-Amaryl Tablet 30's

Semi-Amaryl Tablet 30's belongs to a class of antidiabetic called 'sulfonylureas' used to lower raised blood sugar levels in Type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus - NIDDM). Type 2 diabetes develops if the body does not produce enough insulin or when your body's insulin does not work as well as it should. Insulin is a substance that helps to lower the level of sugar in your blood, especially after meals.

The Semi-Amaryl Tablet 30's contains Glimepiride which acts on insulin-secreting cells called beta cells inside the pancreas and activates calcium channels on cells which lets insulin pass out of the cell. This insulin then makes each cell in the body take up glucose and utilize it, thus lowering raised blood glucose. Therefore, it prevents symptoms of type 2 diabetes.

Take Semi-Amaryl Tablet 30's as prescribed by your doctor. Some people may experience an allergic reaction (skin rash, hives & sensitivity to sun rays), liver dysfunction (jaundice, bile duct blockage, and hepatitis), seizures, coma & low glucose levels. Most of these side effects of Semi-Amaryl Tablet 30's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. 

Semi-Amaryl Tablet 30's should not be stopped even if you feel better without consulting your doctor as the sugar level keeps changing. If you stop taking Semi-Amaryl Tablet 30's abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Semi-Amaryl Tablet 30's should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease or plan to get pregnant or breastfeed.

Uses of Semi-Amaryl Tablet 30's

Type 2 diabetes

Medicinal Benefits Mweb

Medicinal Benefits

Semi-Amaryl Tablet 30's is used in people with type 2 diabetes to minimize elevated blood sugar levels with a balanced diet and exercise in combination. Semi-Amaryl Tablet 30's can be combined with insulin or other forms of oral antidiabetic medication. Semi-Amaryl Tablet 30's decreases blood sugar levels in a diabetic patient by increasing the production and secretion of insulin from the pancreas beta cells. Thus, it helps in controlling increased blood sugar levels after the meal.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Side Effects of Semi-Amaryl Tablet 30's

  • Allergic reactions
  • Headache
  • Nausea
  • Blood pressure drop
  • Shock
  • Abnormal liver function
  • Including skin and eye yellowing (jaundice)
  • Bile flow issues (cholestasis)
  • Liver inflammation (hepatitis) or failure of the liver

Drug Warnings

Before taking Semi-Amaryl Tablet 30's, inform your doctor if you are healing from injury, had or going to have surgery, have fever infections or other sources of stress, then contact your doctor as it might be appropriate to adjust care temporarily. If you have a serious kidney/liver disease, breastfeeding or pregnant, consult the doctor before using Semi-Amaryl Tablet 30's. Do not take Semi-Amaryl Tablet 30's if you are allergic to sulpha drugs, glimepiride, or any other antidiabetic medicines or have a deficiency of glucose 6-phosphate dehydrogenase (G6PD). A heart disease patient should consult a doctor before taking the Semi-Amaryl Tablet 30's as it may worsen the heart disease's current conditions. Do not take Semi-Amaryl Tablet 30's with oral contraceptives as it may increase blood sugar levels. On the other hand, taking Semi-Amaryl Tablet 30's with pain killers like aspirin or ibuprofen can lower your blood sugar.

Drug-Drug Interactions

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GlimepirideBisoprolol
Severe
GlimepirideKetoprofen
Severe

Drug-Drug Interactions

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GlimepirideBisoprolol
Severe
How does the drug interact with Semi-Amaryl Tablet 30's:
Concomitant use of bisoprolol with Semi-Amaryl Tablet 30's may increase the risk, severity, and/or duration of hypoglycemia (low blood sugar). It may also mask some of the symptoms of hypoglycemia such as palpitation, tremor, and rapid heartbeat, making it more difficult to recognize an oncoming episode.

How to manage the interaction:
Although there may be an interaction, bisoprolol can be taken with Semi-Amaryl Tablet 30's if prescribed by the doctor. Consult the prescriber if you develop symptoms of low blood sugar like shakiness, dizziness, sweating, nausea, hunger, weakness, or lightheadedness.
GlimepirideKetoprofen
Severe
How does the drug interact with Semi-Amaryl Tablet 30's:
Taking Ketoprofen with Semi-Amaryl Tablet 30's may increase the risk of hypoglycemia (low blood sugar).

How to manage the interaction:
Although there is a possible interaction, Semi-Amaryl Tablet 30's can be taken with Ketoprofen if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not taking the medications without consulting a doctor.
GlimepirideAmprenavir
Severe
How does the drug interact with Semi-Amaryl Tablet 30's:
Co-administration of Amprenavir and Semi-Amaryl Tablet 30's may interfere with blood glucose control and reduce the effectiveness of Semi-Amaryl Tablet 30's.

How to manage the interaction:
Although taking Semi-Amaryl Tablet 30's and Amprenavir together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs - really high or low blood sugar levels - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
GlimepirideCiprofloxacin
Severe
How does the drug interact with Semi-Amaryl Tablet 30's:
Taking ciprofloxacin with Semi-Amaryl Tablet 30's can cause both hyperglycemia (high blood sugar) and, less frequently, hypoglycemia (low blood sugar).

How to manage the interaction:
Although taking ciprofloxacin and Semi-Amaryl Tablet 30's together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor if you experience such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, excessive sweating, and rapid heartbeat or increased thirst, increased hunger, and increased urination. Do not discontinue the medications without consulting a doctor.
GlimepirideBumetanide
Severe
How does the drug interact with Semi-Amaryl Tablet 30's:
Bumetanide may interfere with blood glucose control and reduce the effectiveness of Semi-Amaryl Tablet 30's.

How to manage the interaction:
Although there is a possible interaction, Semi-Amaryl Tablet 30's can be taken with bumetanide if prescribed by the doctor. Monitoring of blood glucose levels is advised.
GlimepirideParoxetine
Severe
How does the drug interact with Semi-Amaryl Tablet 30's:
Taking Semi-Amaryl Tablet 30's with Paroxetine may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, Semi-Amaryl Tablet 30's can be taken with paroxetine if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar like headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
GlimepirideVoriconazole
Severe
How does the drug interact with Semi-Amaryl Tablet 30's:
Co-administration of Semi-Amaryl Tablet 30's with Voriconazole may increase the blood levels and effects of Semi-Amaryl Tablet 30's.

How to manage the interaction:
Although there is a possible interaction, Semi-Amaryl Tablet 30's can be taken with voriconazole if prescribed by the doctor. Consult the prescriber if you experience headache, dizziness, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
GlimepirideCitalopram
Severe
How does the drug interact with Semi-Amaryl Tablet 30's:
Taking Semi-Amaryl Tablet 30's with Citalopram may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, Semi-Amaryl Tablet 30's can be taken with Citalopram if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
GlimepirideGrepafloxacin
Severe
How does the drug interact with Semi-Amaryl Tablet 30's:
Co-administration of Semi-Amaryl Tablet 30's with Grepafloxacin can sometimes affect blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose) have been reported.

How to manage the interaction:
Although there is a possible interaction between Semi-Amaryl Tablet 30's and Grepafloxacin, you can take these medicines together if prescribed by a doctor. If you experience any of these symptoms - low blood sugar, headache, dizziness, sleepiness, confusion, shaking, feeling hungry, weak, heart racing, high blood sugar, low blood sugar, serious infections, bleeding, feeling anxious, feeling sick or very thirsty - make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
GlimepirideFurosemide
Severe
How does the drug interact with Semi-Amaryl Tablet 30's:
Co-administration of Furosemide may interfere with blood glucose control and lower the effectiveness of Semi-Amaryl Tablet 30's.

How to manage the interaction:
Although there is a possible interaction, Semi-Amaryl Tablet 30's can be taken with furosemide if prescribed by the doctor. Regular monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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GLIMEPIRIDE-0.5MGHypertensive heart and renal disease
Severe
GLIMEPIRIDE-0.5MGUnspecified kidney failure
Severe

Drug-Diseases Interactions

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GLIMEPIRIDE-0.5MGHypertensive heart and renal disease
Severe
How does the disease interact with Semi-Amaryl Tablet 30's:
When compared to diet alone or diet plus insulin, the use of oral hypoglycemic medications may be associated with an increased risk of cardiovascular mortality. This alert is based on the University Group Diabetes Programme (UGDP) project, a long-term prospective clinical investigation aimed to assess the efficacy of glucose-lowering medications in preventing or delaying vascular problems in non-insulin-dependent diabetes patients. Patients treated for 5 to 8 years with diet with a fixed dose of either tolbutamide (a sulfonylurea) or phenformin (a biguanide) had a cardiovascular death risk nearly 2.5 times that of patients treated with diet alone, resulting in the cessation of both therapies in the research. Regardless of how these findings are interpreted, doctors and patients should be aware of the possibility.

How to manage the interaction:
The use of oral hypoglycemic agents may be associated with an increased risk of heart problems. Let the doctor know if you have heart problems.
GLIMEPIRIDE-0.5MGUnspecified kidney failure
Severe
How does the disease interact with Semi-Amaryl Tablet 30's:
Sulfonylureas are metabolised in the liver and eliminated in the urine and faeces as metabolites (some of which have pharmacologic activity). Patients with poor liver and/or renal function who are treated with sulfonylureas may be exposed to increased serum drug concentrations, increasing the risk of severe hypoglycemia episodes. In the context of hepatic impairment, gluconeogenic ability may be reduced, adding to the risk. Sulfonylurea therapy should be used with caution in people who have liver or kidney illness. It is possible that lower dosages and longer intervals between dosage adjustments will be required. If hypoglycemia occurs during treatment, it may be prolonged in these patients due to slower medication metabolism and/or excretion.

How to manage the interaction:
In patients with kidney problems, severe hypoglycemic episodes may occur. Therapy should be administered cautiously in patients with renal disease.
GLIMEPIRIDE-0.5MGOther disorders of adrenal gland
Moderate
How does the disease interact with Semi-Amaryl Tablet 30's:
Hypoglycemia is a common side effect of insulin and/or oral hypoglycemic medications. Patients who are debilitated or malnourished, those with defective counterregulatory mechanisms (e.g., autonomic neuropathy and adrenal or pituitary insufficiency), and those receiving beta-adrenergic blocking agents should exercise caution when using these drugs.

How to manage the interaction:
Care should be taken in patients who may be particularly susceptible to the development of hypoglycemic episodes during treatment.
GLIMEPIRIDE-0.5MGAnaemia due to enzyme disorders
Moderate
How does the disease interact with Semi-Amaryl Tablet 30's:
In patients with glucose 6-phosphate dehydrogenase (G6PD) impairment, sulfonylureas can cause hemolytic anaemia. In individuals with G6PD deficiency, these medicines should be administered with caution, and a non-sulfonylurea option should be considered. Postmarketing reports of hemolytic anaemia in patients receiving these medications who did not have known G6PD deficiency have been received.

How to manage the interaction:
Therapy should be used with caution in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. The use of a non-sulfonylurea alternative should be considered.
GLIMEPIRIDE-0.5MGOther disorders of fluid, electrolyte and acid-base balance
Moderate
How does the disease interact with Semi-Amaryl Tablet 30's:
Treatment with sulfonylureas may cause hyponatremia in individuals who are taking other drugs or have medical disorders that cause hyponatremia, or it may stimulate the secretion of antidiuretic hormone. Certain sulfonylureas have been linked to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion, and these medications may enhance the peripheral (antidiuretic) action of ADH and/or increase ADH release. Caution should be exercised when treating individuals who have hyponatremia or are at increased risk of developing hyponatremia, such as the elderly, those using diuretics, or those who are volume-depleted.

How to manage the interaction:
Caution should be used when treating patients with low sodium or at greater risk of developing low sodium such as elderly patients, patients taking diuretics or those who are volume-depleted.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • ROSUVASTATIN
  • DULOXETINE
  • DAPAGLIFLOZIN
  • GLYBURIDE
  • INSULIN
  • CANAGLIFLOZIN
  • SITAGLIPTIN
  • EMPAGLIFLOZIN
  • FUROSEMIDE
  • ATORVASTATIN
  • PREGABALIN
  • METFORMIN
  • NAPROXEN
  • CLOPIDOGREL
  • IBUPROFEN
  • WARFARIN

Habit Forming

No

Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain healthy body weight as obesity is also related to the onset of diabetes.
  • Maintain a low fat and a low sugar diet. Replace carbohydrates containing foods with whole grains, fruits and vegetables as carbohydrates turn to sugars leading to high blood sugar.
  • Avoid consumption of alcohol and quit smoking.

Semi-Amaryl Tablet 30's Substitute

Substitutes safety advice
  • GP-0.5 Tablet 10's

    5.99per tablet
  • Zoryl-0.5 Tablet 15's

    7.26per tablet
  • Glimsafe 2 mg Tablet 10's

    5.58per tablet
  • G-Mine 2 Tablet 10's

    10.62per tablet
  • Fitglim 0.5 Tablet 30's

    4.05per tablet
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