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  1. Home
  2. Medicine

  3. Restasis Ophthalmic Emulsion 0.4 ml

Prescription drug
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Composition :

CYCLOSPORINE-0.05%W/V

Manufacturer/Marketer :

Allergan Healthcare India Pvt Ltd

Consume Type :

OPHTHALMIC

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

IMMUNOSUPPRESSANTS

Country of origin

India

Manufacturer/Marketer address

No.3, Kasturba Road, Level 2, Prestige Obelisk, Bangalore ? 560 001., KARNATAKA, INDIA
Other Info - RES0411

Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:46 AM IST

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FAQs

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

The interaction of alcohol with Restasis Ophthalmic Emulsion is unknown. Please consult a doctor before consuming alcohol with Restasis Ophthalmic Emulsion .

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Pregnancy

Safe if prescribed

Consult your doctor before using Restasis Ophthalmic Emulsion if you are pregnant. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Safe if prescribed

If you are breastfeeding, consult your doctor before using Restasis Ophthalmic Emulsion . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Restasis Ophthalmic Emulsion may cause temporary blurred vision immediately after applying. Therefore, wait until your vision is clear before driving or operating machinery.

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Liver

Safe if prescribed

If you have any concerns regarding the use of Restasis Ophthalmic Emulsion in patients with liver problems, please consult your doctor.

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Kidney

Safe if prescribed

If you have any concerns regarding the use of Restasis Ophthalmic Emulsion in patients with kidney problems, please consult your doctor.

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Children

Caution

Restasis Ophthalmic Emulsion should be used in children only if it is advised by a doctor. It is not recommended for use in children less than four years.

Product Substitutes

Reference

  1. https://www.medicines.org.uk/emc/product/6937/pil#gref
  2. https://www.ema.europa.eu/en/documents/product-information/verkazia-epar-product-information_en.pdf
  3. https://www.nottsapc.nhs.uk/media/1058/ciclosporin-info-sheet.pdf

About Restasis Ophthalmic Emulsion

Restasis Ophthalmic Emulsion belongs to the class of medicines called immunosuppressants used in the treatment of severe keratitis (inflammation of the cornea) in adults. Also, it is used to treat dry eyes in patients whose condition has not been improved with artificial tears. A dry eye is a common condition that occurs when tears are unable to provide sufficient moisture. 

Restasis Ophthalmic Emulsion contains Cyclosporine, which works by increasing tear production and decreasing inflammation (swelling) in the eye. 

Use Restasis Ophthalmic Emulsion as prescribed by your doctor. Restasis Ophthalmic Emulsion is only for use in eyes. You are advised to use Restasis Ophthalmic Emulsion for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience eye irritation, eye pain, watery eyes, itching in the eye, redness or swelling of the eyelid, and blurred vision using Restasis Ophthalmic Emulsion . Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Please tell your doctor if you are allergic to Restasis Ophthalmic Emulsion or any other medicines. If you are pregnant or breastfeeding, please consult your doctor before using Restasis Ophthalmic Emulsion . Avoid using Restasis Ophthalmic Emulsion while you are wearing contact lenses. Drive only if your vision is clear, as Restasis Ophthalmic Emulsion may cause temporary blurred vision immediately after applying. If you have or had an eye infection, inform your doctor before using Restasis Ophthalmic Emulsion . 

Uses of Restasis Ophthalmic Emulsion

Dry eyes and severe keratitis

Medicinal Benefits Mweb

Medicinal Benefits

Restasis Ophthalmic Emulsion contains Cyclosporine, an immunosuppressant that increases tear production and decreases inflammation (swelling) in the eye. Thus, it is used in the treatment of severe keratitis (inflammation of the cornea) and to treat dry eyes in patients whose condition has not been improved with artificial tears. 

Directions for Use

Lie down and tilt your head backwards. Pull your lower eyelid gently with your index finger to form a pocket. Instil the number of drops as advised by the doctor into the pocket of the lower eyelid. Close your eyes for 1-2 minutes. Do not touch the tip of the container to the eye, eyelids or surrounding areas as it may contaminate Restasis Ophthalmic Emulsion . Restasis Ophthalmic Emulsion is for external use only. Do not inject Restasis Ophthalmic Emulsion .

Side Effects of Restasis Ophthalmic Emulsion

  • Eye irritation
  • Eye pain
  • Watery eyes
  • Itching in the eye
  • Redness or swelling of the eyelid
  • Blurred vision

Drug Warnings

Please tell your doctor if you are allergic to Restasis Ophthalmic Emulsion or any other medicines. If you are pregnant or breastfeeding, please consult a doctor. Avoid using Restasis Ophthalmic Emulsion while you are wearing contact lenses. Drive only if your vision is clear, as Restasis Ophthalmic Emulsion may cause temporary blurred vision immediately after applying. If you have or had an eye infection, inform your doctor before using Restasis Ophthalmic Emulsion . You are recommended to maintain a time gap of 15 minutes between using other eye medicines and Restasis Ophthalmic Emulsion . Discard the bottle after 4 weeks of first opening to prevent infections.

Drug-Drug Interactions

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CiclosporinBaricitinib
Critical
CiclosporinCidofovir
Critical

Drug-Drug Interactions

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CiclosporinBaricitinib
Critical
How does the drug interact with Restasis Ophthalmic Emulsion 0.4 ml:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Restasis Ophthalmic Emulsion 0.4 ml with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinCidofovir
Critical
How does the drug interact with Restasis Ophthalmic Emulsion 0.4 ml:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Restasis Ophthalmic Emulsion 0.4 ml with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CiclosporinSimvastatin
Critical
How does the drug interact with Restasis Ophthalmic Emulsion 0.4 ml:
Combining Restasis Ophthalmic Emulsion 0.4 ml and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Restasis Ophthalmic Emulsion 0.4 ml and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
CiclosporinPitavastatin
Critical
How does the drug interact with Restasis Ophthalmic Emulsion 0.4 ml:
Coadministration of pitavastatin with Restasis Ophthalmic Emulsion 0.4 ml may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Restasis Ophthalmic Emulsion 0.4 ml is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
CiclosporinBosentan
Critical
How does the drug interact with Restasis Ophthalmic Emulsion 0.4 ml:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Restasis Ophthalmic Emulsion 0.4 ml with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinInfliximab
Severe
How does the drug interact with Restasis Ophthalmic Emulsion 0.4 ml:
When infliximab is taken with cyclosporine, it can increase the risk of infections.

How to manage the interaction:
Although taking infliximab and Restasis Ophthalmic Emulsion 0.4 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, contact a doctor immediately if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
CiclosporinSulfasalazine
Severe
How does the drug interact with Restasis Ophthalmic Emulsion 0.4 ml:
Coadministration of sulfasalazine with Restasis Ophthalmic Emulsion 0.4 ml may significantly increase the side effects on kidneys.

How to manage the interaction:
Although there is a possible interaction between sulfasalazine and Restasis Ophthalmic Emulsion 0.4 ml, they can be taken together if your doctor has prescribed them. In case you experience any unusual side effects, consult a doctor. Do not stop using any medications without first talking to a doctor.
CiclosporinCisapride
Severe
How does the drug interact with Restasis Ophthalmic Emulsion 0.4 ml:
Coadministration of cisapride with cyclosporine may significantly increase the blood levels of cisapride which may increase the risk of an irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between cisapride and Restasis Ophthalmic Emulsion 0.4 ml, but it can be taken if prescribed by a doctor. However, contact a doctor immediately if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
CiclosporinEdoxaban
Severe
How does the drug interact with Restasis Ophthalmic Emulsion 0.4 ml:
Taking edoxaban and Restasis Ophthalmic Emulsion 0.4 ml can significantly increase the blood levels of edoxaban.

How to manage the interaction:
Taking Restasis Ophthalmic Emulsion 0.4 ml with edoxaban together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience bleeding, bruising, blood in stools or urine, dizziness, severe headache, weakness, or vomiting contact a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinSaquinavir
Severe
How does the drug interact with Restasis Ophthalmic Emulsion 0.4 ml:
Taking Restasis Ophthalmic Emulsion 0.4 ml with saquinavir may increase the blood levels and effects of Restasis Ophthalmic Emulsion 0.4 ml.

How to manage the interaction:
Taking saquinavir with Restasis Ophthalmic Emulsion 0.4 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of nausea, vomiting, diarrhea, abdominal pain, dizziness, weakness, headache, shaking, fits, fever, sore throat, unusual bruising or bleeding, and increased or decreased urination, contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Habit Forming

No

Special Advise

Regular eye examinations are recommended every 3 to 6 months to assess the effects of Restasis Ophthalmic Emulsion .

Diet & Lifestyle Advise

  • Use a humidifier in your room to increase moisture and avoid dry climates. 
  • Limit the time you spend in front of the television or computer.
  • If dry eyes are caused by environmental factors, wear protective eyewear during outdoor activities when it’s windy and avoid exposure to cigarette smoke. 
  • Limit wearing contact lenses and use soft contact lenses if you have dry eyes, as they are moist and allow the eye to breathe better than hard contact lenses.
  • Take omega-3-fatty acid supplements as they may be helpful in treating dry eyes. 

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