Parnil-2 Tablet 10's

Parnil-2 Tablet 10's belongs to a group of medicines called anti-spasmodic agents used as an adjunct to treat Parkinson’s disease and extrapyramidal symptoms (drug-induced movement disorders). Parkinson’s disease is a progressive neurological disorder in which the first signs are problems with movements. 

Parnil-2 Tablet 10's contains ‘Trihexyphenidyl’ which works by relaxing the muscles and nerve impulses that control muscle functioning. Besides this, Parnil-2 Tablet 10's also balances chemical messengers called neurotransmitters in the brain; thereby improving muscle control and reducing stiffness, thereby helps the muscles move naturally. 

In some cases, you may experience common side-effects such as nausea, vomiting, dizziness, constipation, weakness, headache, dry mouth, decreased urination, drowsiness, and feeling nervous or restless. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side-effects persist or worsen.

Consult your doctor if you are pregnant or breastfeeding. Parnil-2 Tablet 10's may cause drowsiness and dizziness, do not drive unless you are alert. Parnil-2 Tablet 10's should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Parnil-2 Tablet 10's as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your medicines and health condition to rule out any side-effects.

Parnil-2 Tablet 10's belongs to a group of medicines called anti-spasmodic agents. Parnil-2 Tablet 10's is used to treat the symptoms of Parkinson’s disease and extrapyramidal symptoms (drug-induced movement disorders). Parnil-2 Tablet 10's exerts a direct inhibitory effect upon the parasympathetic nervous system. It works by relaxing the muscles and nerve impulses that control muscle functioning. Parnil-2 Tablet 10's improves muscle control and reduces stiffness, thereby helps the muscles move naturally. Parnil-2 Tablet 10's is used as an adjuvant therapy along with levodopa to treat Parkinson's disease. Additionally, Parnil-2 Tablet 10's is used to control drug-induced movement disorders caused by CNS drugs such as dibenzoxazepines, thioxanthenes, phenothiazines, and butyrophenones.

• Nausea
• Vomiting
• Dizziness
• Constipation
• Weakness 
• Headache
• Dry mouth
• Decreased urination
• Drowsiness
• Feeling nervous or restless

Do not take Parnil-2 Tablet 10's if you are allergic to any of its contents or if you have narrow-angle glaucoma. Do not discontinue Parnil-2 Tablet 10's on your own. Inform your doctor if you have glaucoma, prostate problems, urination problems, stomach ulcers, acidity, myasthenia gravis (muscle problems), tardive dyskinesia (involuntary facial movements), alcoholism, high blood pressure, heart, liver or kidney problems. Talk to your doctor immediately if you experience hallucinations. Consult your doctor if you are pregnant or breastfeeding. Parnil-2 Tablet 10's may cause drowsiness and dizziness, do not drive unless you are alert. Parnil-2 Tablet 10's should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Parnil-2 Tablet 10's as it could lead to increased drowsiness and dizziness.

Drug-Drug Interactions: Parnil-2 Tablet 10's may have interaction with antipsychotic (aripiprazole, lurasidone, olanzapine, risperidone, quetiapine, trifluoperazine), MAO inhibitor (rasagiline), antihistamine (diphenhydramine), anti-cholinergic (benztropine), anti-convulsant (clonazepam, lamotrigine, pregabalin), anti-depressants (escitalopram, duloxetine) anti-anxiety (alprazolam), and mild pain killers/fever-reducing agent (acetaminophen).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have arrhythmia (irregular heartbeats), autonomic neuropathy (nerve damage), gastrointestinal obstruction, glaucoma, urinary obstruction, infectious diarrhoea, tardive dyskinesia (involuntary facial movements), psychoses, high blood pressure, or fever.

• ARIPIPRAZOLE
• LURASIDONE
• OLANZAPINE
• RISPERIDONE
• QUETIAPINE
• TRIFLUOPERAZINE
• RASAGILINE
• DIPHENHYDRAMINE
• BENZTROPINE MESYLATE
• CLONAZEPAM
• LAMOTRIGINE
• PREGABALIN
• ESCITALOPRAM
• DULOXETINE
• ALPRAZOLAM
• ACETAMINOPHEN

• Maintain a healthy diet and exercise regularly.
• Include a diet rich in iron, folate and magnesium. 
• Regularly attend therapy sessions.
• Perform meditation and yoga.
• Follow a regular sleep pattern.
• Avoid smoking and alcohol consumption.
• Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

• Take Parnil-2 Tablet 10's at least 2 hours after taking ketoconazole and antidiarrheal medicines as it may prevent the full absorption of trihexyphenidyl. Besides this, Parnil-2 Tablet 10's may prevent the complete absorption of antifungal agents like ketoconazole when these medicines are taken together.
• Parnil-2 Tablet 10's can cause decreased sweating, resulting in a rise in body temperature (hyperthermia). This profound side effect is more significant in hot weather, so it is advisable to drink plenty of water, especially in summer. However, kidney patients should consult a doctor before consuming any fluid.
• Take special care with your dental hygiene while using Parnil-2 Tablet 10's (like brushing, and flossing) and have regular dental check-ups.

Parkinson’s disease: It is a progressive neurological disorder in which the first signs are problems with movements. Dopamine is a naturally-occurring neurotransmitter in the brain which is reduced or absent in people with Parkinson’s disease. Due to this, problems arise with smooth and coordinated movements. Symptoms include decreased ability to smell, stooped posture, changes in voice, constipation, small/ cramped handwriting, tremor, slow movements, stiffness of arms, legs, trunk, and balance problems.