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  1. Home
  2. Medicine

  3. Murinact 4gm Injection

Prescription drug
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Composition :

FOSFOMYCIN-4000MG

Manufacturer/Marketer :

Fusion Health Care Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIBIOTICS

Country of origin

India

Manufacturer/Marketer address

Fusion House, Plot No. 22, H.No 8-2-350/B, Road No. 3, Banjara Hills, Hyderabad, Telangana-500034
Other Info - MUR0033

Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:46 AM IST

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FAQs

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

The interaction of alcohol with Murinact 4gm Injection is unknown. Hence, avoid or limit alcohol consumption while on treatment with Murinact 4gm Injection.

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Pregnancy

Safe if prescribed

Murinact 4gm Injection is considered safe to be used in pregnancy. However, if you are pregnant, inform your doctor before receiving Murinact 4gm Injection. Your doctor prescribes this medicine if the benefits outweigh the risks.

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Breast Feeding

Safe if prescribed

Small amounts of Murinact 4gm Injection are excreted in human milk. Therefore, it is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

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Driving

Caution

Murinact 4gm Injection may cause weakness or confusion in some people. Therefore, avoid driving if you notice any of these symptoms after taking Murinact 4gm Injection.

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Liver

Caution

Please consult a doctor if you have a history of liver diseases/conditions.

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Kidney

Caution

Take Murinact 4gm Injection with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Murinact 4gm Injection may be used with caution in children if prescribed by a doctor, and the dose depends on the child’s age and weight.

Product Substitutes

Reference

  1. https://www.medicines.org.uk/emc/product/11249/smpc
  2. https://ec.europa.eu/health/documents/community-register/2020/20200609148048/anx_148048_en.pdf
  3. https://www.ciplamed.com/content/crifos-4-gm-injection

About Murinact 4gm Injection

Murinact 4gm Injection belongs to a class of drugs called antibiotics used in the treatment of bacterial infections. Murinact 4gm Injection is used to treat bacterial meningitis (infection of membranes protecting the brain and spinal cord), complicated urinary tract infections, bacterial infections of bones and joints, heart, lungs, central nervous system, stomach, blood, skin, and tissues below the skin. Bacterial infection is a condition in which harmful bacteria grow in the body and cause infection. It can infect any part of the body and multiply very quickly.

Murinact 4gm Injection contains Fosfomycin which works by inhibiting the formation of the bacterial cell walls (a protective covering) that is necessary for their survival. Thereby killing bacteria. Also, Murinact 4gm Injection decreases the attachment of bacteria to cells lining the urinary bladder.

Murinact 4gm Injection will be administered by a healthcare professional. Do not self-administer. You may sometimes experience gastrointestinal disturbances, taste disturbances, or injection site reactions. Most of these side effects of Murinact 4gm Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. 

If you are allergic to Fosfomycin or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before taking Murinact 4gm Injection. Murinact 4gm Injection could be used in children if prescribed by a doctor; the dose depends on the child’s age and weight. If you have experienced diarrhoea after receiving or taking antibiotics, inform your doctor before taking Murinact 4gm Injection. If you have kidney problems or are undergoing dialysis, inform your doctor as the dose may be reduced. 

Uses of Murinact 4gm Injection

Bacterial infections

Medicinal Benefits Mweb

Medicinal Benefits

Murinact 4gm Injection contains Fosfomycin, a broad-spectrum antibiotic that kills gram-negative and gram-positive bacteria that grow aerobically (in the presence of oxygen) and anaerobically (in the absence of oxygen). Bacterial meningitis (infection of the membranes that protect the brain and spinal cord), complicated urinary tract infections, bacterial infections of bones and joints, heart, lungs, central nervous system, stomach, blood, skin, and tissues beneath the skin are all treated with Murinact 4gm Injection. Fosfomycin should be used only when other antibiotics have failed or are ineffective. Murinact 4gm Injection prevents bacterial cell wall formation (a protective covering required for survival). Bacteria are thus killed. Additionally, Murinact 4gm Injection reduces the attachment of bacteria to the cells lining the urinary bladder.

Directions for Use

Murinact 4gm Injection will be administered by a healthcare professional. Do not self-administer.

Side Effects of Murinact 4gm Injection

  • Taste disturbances
  • Gastrointestinal disturbances
  • Injection site reactions

Drug Warnings

If you are allergic to Fosfomycin or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before taking Murinact 4gm Injection. Murinact 4gm Injection may be used with caution in children if prescribed by a doctor; the dose depends on the child’s age and weight. If you had diarrhoea previously after receiving or taking antibiotics, inform your doctor before taking Murinact 4gm Injection. If you have kidney problems or are undergoing dialysis, inform your doctor, as the dose may be reduced. 

Drug-Drug Interactions

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FosfomycinCholera vaccines
Severe
FosfomycinBalsalazide
Severe

Drug-Drug Interactions

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FosfomycinCholera vaccines
Severe
How does the drug interact with Murinact 4gm Injection:
Co-administration of the Cholera vaccine with Murinact 4gm Injection may reduce the activity of the Cholera vaccine.

How to manage the interaction:
If you are currently being treated with Murinact 4gm Injection or have been treated within the last 14 days, inform your doctor before receiving cholera vaccine, live. Avoid receiving cholera vaccine, live until at least 14 days after you complete your antibiotic therapy to ensure adequate vaccine response.
FosfomycinBalsalazide
Severe
How does the drug interact with Murinact 4gm Injection:
Murinact 4gm Injection may reduce the effect of balsalazide when taken orally.

How to manage the interaction:
If you are supposed to take Murinact 4gm Injection and Balsalazide together, your doctor may adjust the dose or monitor you more frequently to use both medications safely.
FosfomycinBCG vaccine
Severe
How does the drug interact with Murinact 4gm Injection:
When BCG vaccine is used with Murinact 4gm Injection, its effectiveness may be reduced.

How to manage the interaction:
Taking Murinact 4gm Injection with the BCG vaccine can lead to an interaction, please consult a doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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FOSFOMYCIN-4000MGVascular disorders of intestine
Severe
FOSFOMYCIN-4000MGCare involving dialysis
Moderate

Drug-Diseases Interactions

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FOSFOMYCIN-4000MGVascular disorders of intestine
Severe
How does the disease interact with Murinact 4gm Injection:
Nearly all antibacterial medications have been associated with Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis, which can range in severity from mild diarrhoea to deadly colitis. Lincomycin and clindamycin are typically to blame. Antibacterial treatment disrupts the colon's normal flora, promoting the growth of C difficile, whose toxins A and B contribute to the emergence of CDAD. When C difficile strains produce hypertoxins, morbidity and death rise; severe infections may not respond to antibiotic therapy and may necessitate colectomy. All individuals who get diarrhoea after taking an antibiotic must be evaluated for CDAD. Careful medical history is required because CDAD has been known to happen more than two months following antibiotic use. Broad-spectrum antibiotics and other medications with potent antibacterial properties should be used in therapy.

How to manage the interaction:
Murinact 4gm Injection should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the large intestine), pseudomembranous colitis (generally characterized by severe, persistent diarrhoea and severe abdominal cramps, and sometimes associated with the passage of blood and mucus).
FOSFOMYCIN-4000MGCare involving dialysis
Moderate
How does the disease interact with Murinact 4gm Injection:
Hemodialysis removes Murinact 4gm Injection, therefore it needs to be given after treatments.

How to manage the interaction:
As Murinact 4gm Injection is removed by hemodialysis, it should be administered after dialysis sessions.
FOSFOMYCIN-4000MGUnspecified kidney failure
Mild
How does the disease interact with Murinact 4gm Injection:
Murinact 4gm Injection is excreted intact in the faeces (18%) and by the kidneys (38%) of healthy adults. In patients with impaired renal function, the excretion of Murinact 4gm Injection is greatly reduced, and the half-life is prolonged. In patients with renal insufficiency, side symptoms (such as diarrhoea, headache, nausea, and vaginitis) may last longer.

How to manage the interaction:
Murinact 4gm Injection should be used with caution in patients with kidney failure. However, if the side effects, such as headache, diarrhoea, nausea, and vaginitis (inflammation or infection of the vagina) worsen, please consult your doctor.

Habit Forming

No

Special Advise

  • The levels of electrolytes are regularly monitored while taking Murinact 4gm Injection as it may cause high sodium or low potassium levels in the blood.

Diet & Lifestyle Advise

  • Take probiotics after completing the full course of Murinact 4gm Injection in order to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like cheese, yoghurt, kombucha, sauerkraut and kimchi can help restore the intestine's good bacteria. 
  • Include fibre-rich foods, as they can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains such as whole-grain bread and brown rice should be included in your diet. 
  • Maintain a low-sodium diet as Murinact 4gm Injection in injection form may increase sodium levels in the blood.
  • Make sure you drink plenty of water or other fluids daily while you are taking Murinact 4gm Injection.

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