apollo
0

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
Insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
  1. Home
  2. Medicine

  3. Monocef-O 400 SR Tablet 5's

Not for online sale
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS

Composition :

CEFPODOXIME-400MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Therapeutic Class

ANTIBIOTICS

Country of origin

India

Manufacturer/Marketer address

Mercantile Chamber, 3rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai 400 001, India.
Other Info - MON1272

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Hari Kumar

Reviewed By

Hari Kumar

MBBS

Last Updated

Jul 8, 2025 | 9:29 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
bannner image

Alcohol

Caution

Avoid consuming alcohol while taking Monocef-O 400 SR Tablet 5's as it might cause increased dizziness.

bannner image

Pregnancy

Caution

Monocef-O 400 SR Tablet 5's belongs to pregnancy category B. Please consult your doctor if you are pregnant; your doctor will prescribe Monocef-O 400 SR Tablet 5's only if the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

Monocef-O 400 SR Tablet 5's passes into breast milk. Please consult your doctor if you are breastfeeding.

bannner image

Driving

Caution

Monocef-O 400 SR Tablet 5's may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.

bannner image

Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have liver impairment/liver disease.

bannner image

Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease.

bannner image

Children

Safe if prescribed

Monocef-O 400 SR Tablet 5's is safe for children if prescribed by the doctor. However, the use of Monocef-O 400 SR Tablet 5's is not recommended for children below 2 months as safety and efficacy have not been established.

Product Substitutes

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/065462s005lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a698024.html
  3. https://mri.cts-mrp.eu/human/downloads/PT_H_0933_003_FinalPI_3of4.pdf
  4. https://www.drugs.com/mtm/cefpodoxime.html

About Monocef-O 400 SR Tablet 5's

Monocef-O 400 SR Tablet 5's belongs to the group of cephalosporin antibiotics used to treat a wide range of bacterial infections of the ear, nose, throat, lower respiratory tract, urinary tract, skin, and soft tissue. Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Monocef-O 400 SR Tablet 5's does not work against infections caused by the virus, including cold and flu.

Monocef-O 400 SR Tablet 5's contains 'Cefpodoxime', which is a broad-spectrum antibiotic effective against both gram-positive and gram-negative bacteria. Monocef-O 400 SR Tablet 5's works by preventing the formation of bacterial cell covering (cell wall), which is necessary for their survival. Thereby, Monocef-O 400 SR Tablet 5's kills the bacteria and helps in treating and preventing the spread of bacterial infections.

In some cases, Monocef-O 400 SR Tablet 5's may cause side effects such as nausea, vomiting, diarrhoea (watery or loose stool), abdominal pain, loss of appetite, bloating, skin rash and itching. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Talk to your doctor if you have/had inflammation in the bowel, kidney or liver problems. Consult your doctor if you are pregnant or breastfeeding. Monocef-O 400 SR Tablet 5's may cause dizziness, so be cautious while driving. Avoid alcohol consumption to prevent unpleasant side effects. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects. 

Uses of Monocef-O 400 SR Tablet 5's

Bacterial infections 

Medicinal Benefits Mweb

Medicinal Benefits

Monocef-O 400 SR Tablet 5's belongs to the group of antibiotic medicines called 'cephalosporins' used to treat a wide range of bacterial infections of the ear, nose, throat, lower respiratory tract, urinary tract, skin, and soft tissue. Monocef-O 400 SR Tablet 5's is a broad-spectrum antibiotic that is effective against gram-positive and gram-negative bacteria, aerobic and some anaerobic bacteria. Monocef-O 400 SR Tablet 5's works by preventing the formation of bacterial cell covering, which is necessary for their survival. Thereby, kills the bacteria and helps in treating and preventing the spread of infections.

Directions for Use

Tablet/capsule: Swallow the tablet/capsule as a whole with water; do not crush, chew or break it.Syrup/Suspension/Drops/Oral solution: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper. Shake the bottle well before each use.Dry syrup: Check the label for directions before use. Shake the bottle well to loosen the powder, and add water up to the mark on the bottle and shake well. Take it as advised by the doctor.Dispersible tablet/Tablet DT: Check the label for directions before use. Disperse the tablet in the prescribed amount of water and swallow the contents. Do not crush, chew or swallow as a whole.

Side Effects of Monocef-O 400 SR Tablet 5's

  • Diarrhoea (loose or watery stool)
  • Nausea
  • Vomiting
  • Abdominal pain
  • Loss of appetite
  • Bloating

Drug Warnings

Do not take Monocef-O 400 SR Tablet 5's if you are allergic to cefpodoxime or any antibiotics. Before taking Monocef-O 400 SR Tablet 5's, let your doctor know if you have/had inflammation in bowel, kidney or liver problems. Consult a doctor if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Monocef-O 400 SR Tablet 5's to prevent unpleasant side effects. Monocef-O 400 SR Tablet 5's may cause dizziness, so be cautious while driving. 

Drug-Drug Interactions

verifiedApollotooltip
CefpodoximeHeparin
Severe
CefpodoximeCholera, live attenuated
Severe

Drug-Drug Interactions

Login/Sign Up

CefpodoximeHeparin
Severe
How does the drug interact with Monocef-O 400 SR Tablet:
Co-administration of Monocef-O 400 SR Tablet with Heparin may enhance the levels or effects of heparin by anticoagulation (preventing blood from clotting).

How to manage the interaction:
Although there is an interaction, Monocef-O 400 SR Tablet can be taken with Heparin if prescribed by the doctor. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.
CefpodoximeCholera, live attenuated
Severe
How does the drug interact with Monocef-O 400 SR Tablet:
Co-administration of Monocef-O 400 SR Tablet with the Cholera vaccine may reduce the effectiveness of the vaccine.

How to manage the interaction:
Talk to your doctor before receiving the Cholera vaccine if you are currently being treated with Monocef-O 400 SR Tablet or have been treated within the last 14 days. To ensure adequate vaccine response, you should not receive cholera vaccine until at least 14 days after you complete your antibiotic therapy. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Drug-Diseases Interactions

verifiedApollotooltip
CEFPODOXIME-400MGOther bacterial intestinal infections
Severe
CEFPODOXIME-400MGDisorders resulting from impaired renal tubular function
Moderate

Drug-Diseases Interactions

Login/Sign Up

CEFPODOXIME-400MGOther bacterial intestinal infections
Severe
How does the disease interact with Monocef-O 400 SR Tablet:
Almost all antibacterial medications have been associated to reports of Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis. It can vary from mild diarrhoea to deadly colitis. Clindamycin and lincomycin are two of the most frequent offenders.

How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
CEFPODOXIME-400MGDisorders resulting from impaired renal tubular function
Moderate
How does the disease interact with Monocef-O 400 SR Tablet:
The kidneys remove the majority of beta-lactam antibiotics as unaltered drugs and, in certain situations, as metabolites as well. In individuals with poor renal function, the blood concentrations of beta-lactam antibiotics and their metabolites may rise and their half-lives may be prolonged. According to the particular product package labelling, dosage modifications may be required. These alterations should be based on the severity of the infection as well as the degree of renal impairment. Renal function tests should be carried out on a regular basis during extended and/or high-dose therapy since these medicines have occasionally been linked to nephrotoxicity and changes in renal function.

How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised.
CEFPODOXIME-400MGAbnormal serum enzyme levels
Moderate
How does the disease interact with Monocef-O 400 SR Tablet:
Certain cephalosporins have been associated with cases of hepatitis. There has also been a brief increase in the levels of AST, ALT, and alkaline phosphatase. Patients with hepatic problems should be treated with caution and under close observation when using these medications.

How to manage the interaction:
Caution and monitoring is recommended in patients with liver disorders.
CEFPODOXIME-400MGEpilepsy
Moderate
How does the disease interact with Monocef-O 400 SR Tablet:
It has been suggested that cephalosporins can cause seizures. In particular in patients with a history of epilepsy and/or where prescribed doses of cephalosporins were exceeded because of renal impairment, cephalosporins have been associated with nonconvulsive status epilepticus (NCSE), encephalopathy, coma, asterixis, neuromuscular excitability, and myoclonia. Depending on the creatinine clearance, change the dosage. In individuals with known seizure disorders, anticonvulsant medication should be maintained. Patients should get a neurological exam to see if medication should be stopped if CNS side effects like seizures happen.

How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Dose adjustment may be needed.

Drug-Drug Interactions Checker List

  • FUROSEMIDE
  • WARFARIN
  • CALCIUM+VITAMIN D3
  • SODIUM BICARBONATE
  • ALUMINIUM HYDROXIDE
  • MAGNESIUM HYDROXIDE
  • CIMETIDINE
  • RANITIDINE
  • LORATADINE
  • PROBENECID

Habit Forming

No

Special Advise

  • If CDAD (clostridium difficile-associated diarrhoea) is confirmed, then appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated. 

Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics, such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.
  • Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid consumption of alcohol and usage of tobacco.

All Substitutes & Brand Comparisons

Health Queries

Have a query?