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  1. Home
  2. Medicine

  3. Macox-ZH Tablet 6's

Not for online sale
Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Composition :

ISONIAZID-150MG+PYRAZINAMIDE-750MG+RIFAMPICIN-225MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

Therapeutic Class

[ANTI- TUBERCULOSIS]

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - MAC0035

Author Details

Lakshmithulasi YarraguntaDoctor badge

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:49 AM IST

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Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Safe if prescribed

-

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Pregnancy

Consult your doctor

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Breast Feeding

Consult your doctor

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Driving

Safe if prescribed

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Liver

Consult your doctor

Macox-ZH Tablet should be used with caution in children with liver problems. Your child's doctor may adjust the dose based on the condition of your child. Liver function tests may be needed while on treatment with this medicine.

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Kidney

Consult your doctor

Macox-ZH Tablet should be used with caution in children with kidney disease. Your child's doctor may adjust the dose based on the condition of your child.

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Children

Safe if prescribed

Macox-ZH Tablet is safe for children if prescribed by the doctor. Your child's doctor will decide the dose of the medicine. Do not give more than the recommended dose to your child.

Product Substitutes

Reference

  1. https://extranet.who.int/pqweb/sites/default/files/TB309part6v1.pdf
  2. https://mahimaimedicals.myshopify.com/products/akurit-z-kid-tablet
  3. http://doshimedicare.com/2021/08/13/macox-zh-kid-dispersible-tablets-of-rifampicin-isoniazid-and-pyrazinamide/

About Macox-ZH Tablet

Macox-ZH Tablet belongs to the group of medicines called anti-mycobacterial drugs primarily used to treat tuberculosis (TB). Tuberculosis is an infectious respiratory disease that affects the lungs but can also spread to other body parts such as the kidneys, brain, spine, and bone marrow. 

Macox-ZH Tablet is a combination medicine containing rifampicin, isoniazid, and pyrazinamide, which belong to an anti-tubercular class of drugs. It works by destroying the bacteria that is responsible for causing lung infection known as Tuberculosis (TB). The bacteria that causes the infection is Mycobacterium tuberculosis.

Macox-ZH Tablet may cause certain side effects in your child, such as indigestion, headache, nausea, and vomiting. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your paediatrician. Macox-ZH Tablet should be given as advised by your doctor. Do not give more than the prescribed dose to the child. It can be given with or without food. Generally, the dose of the medicine will be decided by your paediatrician, depending upon the severity of the infection. Finish the full course of treatment, and do not skip any doses even if your child starts feeling good.

Macox-ZH Tablet is intended for pediatric use only. Avoid giving Macox-ZH Tablet to your child if she/he is allergic to any of the components present in this medicine. Keep your doctor informed about your child’s health condition, including his current medications and medical history, to rule out any side effects/interactions. Before giving Macox-ZH Tablet, tell your paediatrician if your child has eye problems, liver disease, or kidney disease.

Uses of Macox-ZH Tablet

Tuberculosis (TB)

Medicinal Benefits Mweb

Key Benefits

Macox-ZH Tablet contains rifampicin, isoniazid, and pyrazinamide, which is an anti-tuberculosis medicine. It destroys the bacteria responsible for causing lung infection known as Tuberculosis (TB). The bacteria that causes the infection is Mycobacterium tuberculosis. Do not stop giving this medicine without informing your doctor; doing so may cause the infection to return or worsen. Adhere to your doctor's instructions carefully to get maximum benefit.

Directions for Use

Macox-ZH Tablet should be given as advised by the paediatrician. It can be given with or without food. Before giving, disperse the tablet in a glass of water, mix well and then give it to your child. Do not make your child chew or crush the tablet. It is advised not to skip any dose of Macox-ZH Tablet.

Side Effects of Macox-ZH Tablet

  • Nausea
  • Vomiting
  • Loss of appetite
  • Headaches
  • Dizziness
  • Confusion

Drug Warnings

 

Drug-Drug Interactions

verifiedApollotooltip
IsoniazidRegorafenib
Critical
IsoniazidLomitapide
Critical

Drug-Drug Interactions

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IsoniazidRegorafenib
Critical
How does the drug interact with Macox-ZH Tablet:
When Macox-ZH Tablet is taken with Regorafenib, it can increase the levels of Regorafenib leading to side effects.

How to manage the interaction:
Taking Regorafenib with Macox-ZH Tablet is not recommended, it taken can be taken if prescribed by the doctor.
IsoniazidLomitapide
Critical
How does the drug interact with Macox-ZH Tablet:
When Lomitapide is taken with Macox-ZH Tablet, Macox-ZH Tablet may increase the blood levels of lomitapide which leads to side effects.

How to manage the interaction:
Taking Macox-ZH Tablet with Lomitapide is not recommended but can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor.
IsoniazidLovastatin
Critical
How does the drug interact with Macox-ZH Tablet:
When Lovastatin is taken with Macox-ZH Tablet, can increase the risk of myopathy (muscles problems), including rhabdomyolysis (a condition that causes your muscles to break down, which leads to muscle death).

How to manage the interaction:
Taking Macox-ZH Tablet with Lovastatin is not recommended but can be taken if a doctor has prescribed it.
RifampicinSaquinavir
Critical
How does the drug interact with Macox-ZH Tablet:
Taking saquinavir with Macox-ZH Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between pyrazinamide and Macox-ZH Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, stomach pain, less desire to eat, nausea, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinIndinavir
Critical
How does the drug interact with Macox-ZH Tablet:
When Indinavir is taken with Macox-ZH Tablet, it can reduce the blood levels and effects of Indinavir.

How to manage the interaction:
Although there is an interaction between indinavir and Macox-ZH Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinPirfenidone
Critical
How does the drug interact with Macox-ZH Tablet:
Taking pirfenidone with Macox-ZH Tablet can reduce the levels and effects of pirfenidone

How to manage the interaction:
Although there is an interaction between pirfenidone and Macox-ZH Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinDarunavir
Critical
How does the drug interact with Macox-ZH Tablet:
Taking darunavir with Macox-ZH Tablet can decrease the blood levels of darunavir, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between darunavir and Macox-ZH Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinVoriconazole
Critical
How does the drug interact with Macox-ZH Tablet:
Taking Voriconazole with Macox-ZH Tablet can increase blood level of Voriconazole.

How to manage the interaction:
Although there is an interaction between Voriconazole with Macox-ZH Tablet, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinRanolazine
Critical
How does the drug interact with Macox-ZH Tablet:
When ranolazine is taken with Macox-ZH Tablet, it can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between ranolazine and Macox-ZH Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
IsoniazidTeriflunomide
Severe
How does the drug interact with Macox-ZH Tablet:
Using Macox-ZH Tablet with Teriflunomide can increase the risk and severity of the side effects of the liver.

How to manage the interaction:
Taking Macox-ZH Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to consult a doctor: Fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, nausea, vomiting, abdominal pain, dark urine, light colored stool, and/or yellowing of the skin or eyes. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Habit Forming

No

Special Advise

 

Diet & Lifestyle Advise

  • Undernutrition weakens the body's ability to fight tuberculosis and may worsen the disease. Therefore, children with tuberculosis should have a healthy balanced diet like cereals, millet, pulses, vegetables and fruits, milk products, meat, eggs and fish.
  • Vegetables, especially green leafy vegetables and fruits, are rich in antioxidants and minerals, so they should be a part of your kid's daily diet. 
  • The Health and hygiene of children with TB should be maintained.

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