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  1. Home
  2. Medicine

  3. Macox Plus Tablet 6's

Not for online sale
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Composition :

ISONIAZID-300MG+RIFAMPICIN-450MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

Therapeutic Class

[ANTI- TUBERCULOSIS]

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - MAC0007

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:30 AM IST

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Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Safe if prescribed

Avoid alcohol consumption while taking Macox Plus Tablet as it could lead to increased drowsiness, dizziness and liver damage.

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Pregnancy

Consult your doctor

Please consult your doctor if you are pregnant, your doctor will prescribe Macox Plus Tablet only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Macox Plus Tablet passes into breast milk. Do not breastfeed while taking Macox Plus Tablet.

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Driving

Safe if prescribed

Macox Plus Tablet may cause dizziness, drowsiness, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.

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Liver

Consult your doctor

Dose adjustment may be needed. Please consult your doctor before taking Macox Plus Tablet if you have liver impairment/liver disease.

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Kidney

Consult your doctor

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking Macox Plus Tablet.

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Children

Safe if prescribed

Please consult your doctor. Your doctor may suggest suitable dose and dosage form based on your child's age, body weight and medical condition. Kid tablets could be used in children if prescribed by the doctor.

Product Substitutes

Reference

  1. https://www.medicines.org.uk/emc/files/pil.6124.pdf
  2. https://www.drugs.com/mtm/isoniazid-and-rifampin.html
  3. https://www.medicinesforchildren.org.uk/medicines/isoniazid-and-rifampicin-combination-for-latent-tuberculosis/

About Macox Plus Tablet

Macox Plus Tablet belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as the kidneys, brain, spine, and bone marrow.

Macox Plus Tablet is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, Macox Plus Tablet kills Mycobacterium tuberculosis which causes TB (tuberculosis).

In some cases, you may experience certain common side-effects such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, gas, and numbness or tingling sensation. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor before taking Macox Plus Tablet if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Macox Plus Tablet as it passes into breast milk. Macox Plus Tablet may cause dizziness, and vision problems, so drive only if you are alert. Avoid alcohol consumption while taking Macox Plus Tablet as it could lead to increased drowsiness, dizziness and liver damage.

Uses of Macox Plus Tablet

Tuberculosis.

Medicinal Benefits Mweb

Key Benefits

Macox Plus Tablet is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, Macox Plus Tablet kills Mycobacterium tuberculosis which causes TB (tuberculosis).

Directions for Use

Take Macox Plus Tablet 30 minutes before food or 2 hours after food. Swallow Macox Plus Tablet as a whole; do not crush or chew it.

Side Effects of Macox Plus Tablet

  • Drowsiness
  • Dizziness
  • Headache
  • Weakness
  • Muscle pain 
  • Heartburn 
  • Diarrhoea
  • Gas
  • Numbness 

Drug Warnings

Do not take Macox Plus Tablet if you are allergic to any of its contents; if you have jaundice, or if you are taking HIV medicines (saquinavir or ritonavir). Before starting Macox Plus Tablet, please inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems. Consult your doctor before taking Macox Plus Tablet if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Macox Plus Tablet as it passes into breast milk. Macox Plus Tablet may cause dizziness, and drowsiness, so drive only if you are alert. Avoid alcohol consumption while taking Macox Plus Tablet as it could lead to increased drowsiness, dizziness and liver damage.

Drug-Drug Interactions

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RifampicinSaquinavir
Critical
RifampicinIndinavir
Critical

Drug-Drug Interactions

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RifampicinSaquinavir
Critical
How does the drug interact with Macox Plus Tablet:
Taking saquinavir with Macox Plus Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between pyrazinamide and Macox Plus Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, stomach pain, less desire to eat, nausea, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinIndinavir
Critical
How does the drug interact with Macox Plus Tablet:
When Indinavir is taken with Macox Plus Tablet, it can reduce the blood levels and effects of Indinavir.

How to manage the interaction:
Although there is an interaction between indinavir and Macox Plus Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinPirfenidone
Critical
How does the drug interact with Macox Plus Tablet:
Taking pirfenidone with Macox Plus Tablet can reduce the levels and effects of pirfenidone

How to manage the interaction:
Although there is an interaction between pirfenidone and Macox Plus Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinDarunavir
Critical
How does the drug interact with Macox Plus Tablet:
Taking darunavir with Macox Plus Tablet can decrease the blood levels of darunavir, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between darunavir and Macox Plus Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinVoriconazole
Critical
How does the drug interact with Macox Plus Tablet:
Taking Voriconazole with Macox Plus Tablet can increase blood level of Voriconazole.

How to manage the interaction:
Although there is an interaction between Voriconazole with Macox Plus Tablet, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinRanolazine
Critical
How does the drug interact with Macox Plus Tablet:
When ranolazine is taken with Macox Plus Tablet, it can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between ranolazine and Macox Plus Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
IsoniazidRegorafenib
Critical
How does the drug interact with Macox Plus Tablet:
When Macox Plus Tablet is taken with Regorafenib, it can increase the levels of Regorafenib leading to side effects.

How to manage the interaction:
Taking Regorafenib with Macox Plus Tablet is not recommended, it taken can be taken if prescribed by the doctor.
IsoniazidLomitapide
Critical
How does the drug interact with Macox Plus Tablet:
When Lomitapide is taken with Macox Plus Tablet, Macox Plus Tablet may increase the blood levels of lomitapide which leads to side effects.

How to manage the interaction:
Taking Macox Plus Tablet with Lomitapide is not recommended but can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor.
IsoniazidLovastatin
Critical
How does the drug interact with Macox Plus Tablet:
When Lovastatin is taken with Macox Plus Tablet, can increase the risk of myopathy (muscles problems), including rhabdomyolysis (a condition that causes your muscles to break down, which leads to muscle death).

How to manage the interaction:
Taking Macox Plus Tablet with Lovastatin is not recommended but can be taken if a doctor has prescribed it.
RifampicinBedaquiline
Severe
How does the drug interact with Macox Plus Tablet:
Taking bedaquiline with Macox Plus Tablet can decrease the blood levels of bedaquiline, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between bedaquiline and Macox Plus Tablet, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • SAQUINAVIR
  • RITONAVIR
  • ACETAMINOPHEN
  • HYDROCODONE
  • DULOXETINE
  • BUPROPION
  • DILTIAZEM
  • ETHAMBUTOL
  • PYRAZINAMIDE
  • CHOLECALCIFEROL
  • ERGOCALCIFEROL

Habit Forming

No

Special Advise

  • Macox Plus Tablet may affect test results of some blood tests such as tests for folate, vitamin B12, and liver function. Inform the person doing the tests that you are taking Macox Plus Tablet.
  • Your doctor may advise you to get regular liver tests while taking Macox Plus Tablet to check how your liver is functioning.

Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Foods rich in vitamin C such as kiwi, broccoli, and bell pepper helps in improving the immune system. 
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help in providing relief from cough.
  • Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
  • Quit smoking and avoid alcohol consumption.

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