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  1. Home
  2. Medicine

  3. Lynparza 150 mg Tablet 8's

Prescription drug
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Composition :

OLAPARIB-150MG

Manufacturer/Marketer :

Astra Zeneca Pharma India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore
Other Info - LYN0034

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:49 AM IST

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Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Lynparza 150Mg Tablet.

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Pregnancy

Unsafe

Lynparza 150Mg Tablet should not be used during pregnancy because it can harm your fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Lynparza 150Mg Tablet and at least for six months later treatment. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Breast Feeding

Unsafe

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for one month after the final medication is taken.

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Driving

Caution

Lynparza 150Mg Tablet may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.

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Liver

Caution

In patients with mild or moderate liver impairment, there is no need to alter the initial dose. There is no information available on patients with severe liver impairment.

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Kidney

Caution

In patients with mild or moderate kidney impairment, there is no need to alter the initial dose. There is no information available on patients with severe kidney impairment.

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Children

Caution

The safety and effectiveness of Lynparza 150Mg Tablet in pediatric patients have not been established.

Product Substitutes

Reference

  1. https://www.myeloma.org.uk/wp-content/uploads/2023/04/Myeloma-UK-Panobinostat-Treatment-Guide.pdf
  2. https://www.lynparza.com/
  3. https://medlineplus.gov/druginfo/meds/a614060.html#:~:text=Olaparib%20is%20used%20alone%20or,tissue%20that%20lines%20the%20abdomen)
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208558s001lbl.pdf
  5. https://www.medicines.org.uk/emc/product/9204/pil#gref
  6. https://reference.medscape.com/drug/lynparza-olaparib-999934
  7. https://www.medicines.org.uk/emc/files/pil.9204.pdf
  8. https://www.lynparzahcp.com/
  9. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/olaparib-lynparza#:~:text=Olaparib%20stops%20PARP%20working.&text=healthy.,damage%2C%20the%20cancer%20cells%20die.
  10. https://www.lynparza.com/what-is-lynparza.html
  11. https://www.drugs.com/drug-interactions/olaparib-index.html?filter=3

About Lynparza 150Mg Tablet

Lynparza 150Mg Tablet belongs to a group of medicines known as 'anti-cancer' drugs used to treat various cancers, including Ovarian, breast, pancreatic, and prostate. Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can attack and destroy surrounding healthy tissue, including organs.

Lynparza 150Mg Tablet contains Olaparib, a targeted drug called a PARP inhibitor. PARP (polyadenosine 5’-diphosphoribose polymerase) is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

Use this medicine as directed by your doctor. You may sometimes experience shortness of breath (dyspnoea), feeling very tired, pale skin or fast heartbeat, anaemia, feeling sick (nausea), being sick (vomiting), indigestion or heartburn (dyspepsia), loss of appetite, headache, changes in taste of foods (dysgeusia), feeling dizzy, cough and diarrhoea. Most of these side effects may gradually resolve over time. However, if the side effects persist or worsen, consult your doctor.

To treat your condition effectually, continue taking Lynparza 150Mg Tablet for as long as your doctor has prescribed. Do not stop using the Lynparza 150Mg Tablet midway. Talk to your doctor before taking Lynparza 150Mg Tablet if you have severe allergic reactions to Lynparza 150Mg Tablet or other medicines or suffer from severe infections, renal dysfunction, hepatic disorders and blood cell counts are too low. Avoid taking Lynparza 150Mg Tablet if you are pregnant or breastfeeding because this Lynparza 150Mg Tablet can cause harmful effects on the unborn baby. Both women and men using this Lynparza 150Mg Tablet should use birth control to avoid pregnancy. While on Lynparza 150Mg Tablet treatment, you should avoid eating grapefruit, Seville oranges or consuming grapefruit juice since it can affect how the medicine works.

Uses of Lynparza 150Mg Tablet

Cancer (Ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer)

Medicinal Benefits Mweb

Medicinal Benefits

Lynparza 150Mg Tablet contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells to repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage. Thus, it treats various cancers, including Ovarian, breast, pancreatic, and prostate. It can be used alone or with other chemotherapy drugs, depending on your type of cancer.

Directions for Use

Swallow it as a whole with water; do not crush or chew it.

Side Effects of Lynparza 150Mg Tablet

  • Feeling sick (nausea)
  • Being sick (vomiting)
  • Feeling tired or weak (fatigue)
  • Feeling very tired
  • Indigestion or heartburn (dyspepsia)
  • Loss of appetite
  • Headache
  • Changes in the taste of foods (dysgeusia)
  • Feeling dizzy
  • Cough
  • Shortness of breath (dyspnoea)
  • Diarrhoea
  • Low white blood cell count (leukopenia or neutropenia)
  • Rash
  • Sore mouth (stomatitis)
  • Upper abdominal pain (pain in the stomach area under the ribs)
  • Blood clot in a deep vein, usually in the leg (venous thrombosis)

Drug Warnings

Always take this medicine exactly as your doctor or healthcare professional has told you. To treat your condition effectually, continue taking Lynparza 150Mg Tablet for as long as your doctor has prescribed. Do not stop Lynparza 150Mg Tablet midway. Talk to your doctor before taking Lynparza 150Mg Tablet if you have severe allergic reactions to Lynparza 150Mg Tablet or other medicines or suffer from any medical illness. Avoid taking Lynparza 150Mg Tablet if you are pregnant or breastfeeding because this Lynparza 150Mg Tablet can cause harmful effects on the unborn baby. Both women and men using this Lynparza 150Mg Tablet should use birth control to avoid pregnancy. Do not start Lynparza 150Mg Tablet unless patients have recovered from haematological damage induced by previous chemotherapy (Grade 1). Check full blood count for cytopenia at baseline and monthly afterwards for clinically significant changes during treatment. For persistent haematological toxicity, discontinue Lynparza 150Mg Tablet and monitor blood count weekly until recovery. Do not receive any immunization or vaccination without your doctor's approval while taking the Lynparza 150Mg Tablet.

Drug-Drug Interactions

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OlaparibFosphenytoin
Severe
OlaparibAmprenavir
Severe

Drug-Drug Interactions

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OlaparibFosphenytoin
Severe
How does the drug interact with Lynparza 150 mg Tablet:
When Lynparza 150 mg Tablet is taken with Fosphenytoin, it can cause Lynparza 150 mg Tablet to be broken down faster in the body. This can lead to low treatment outcomes.

How to manage the interaction:
Co-administration of Lynparza 150 mg Tablet with Fosphenytoin can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.
OlaparibAmprenavir
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Using Amprenavir and Lynparza 150 mg Tablet can increase the blood levels of Lynparza 150 mg Tablet. This can increase the risk and/or severity of side effects of Lynparza 150 mg Tablet.

How to manage the interaction:
Combining Amprenavir and Lynparza 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
OlaparibRibociclib
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Using Ribociclib and Lynparza 150 mg Tablet can increase the blood levels of Lynparza 150 mg Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Ribociclib and Lynparza 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
OlaparibErythromycin
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Coadministration of Lynparza 150 mg Tablet and erythromycin may significantly increase the blood levels of Lynparza 150 mg Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, less desire to eat, abdominal pain or discomfort.

How to manage the interaction:
Combining Erythromycin and Lynparza 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
OlaparibTeriflunomide
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Using Teriflunomide together with Lynparza 150 mg Tablet may increase the risk of infections.

How to manage the interaction:
Combining Teriflunomide and Lynparza 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
OlaparibNevirapine
Severe
How does the drug interact with Lynparza 150 mg Tablet:
When Lynparza 150 mg Tablet is taken with Nevirapine may reduce the blood levels of Lynparza 150 mg Tablet. This can lead to low treatment outcomes.

How to manage the interaction:
There may be a possibility of interaction between Nevirapine and Lynparza 150 mg Tablet, but it can be taken if prescribed by a doctor. Do not discontinue any medications without first consulting a doctor.
OlaparibPhenytoin
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Coadministration of Phenytoin and Lynparza 150 mg Tablet may decrease the blood levels of Lynparza 150 mg Tablet, which may make Lynparza 150 mg Tablet less effective.

How to manage the interaction:
Although taking Phenytoin and Lynparza 150 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Without consulting a doctor, never stop taking any drugs.
OlaparibCiprofloxacin
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Using Ciprofloxacin and Lynparza 150 mg Tablet can increase the blood levels of Lynparza 150 mg Tablet. This can increase the risk and severity of side effects.

How to manage the interaction:
Although there is a interaction between ciprofloxacin and Lynparza 150 mg Tablet, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
OlaparibCertolizumab
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Using Certolizumab together with Lynparza 150 mg Tablet may increase the risk of infections.

How to manage the interaction:
Combining Certolizumab and Lynparza 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
OlaparibTofacitinib
Severe
How does the drug interact with Lynparza 150 mg Tablet:
When Tofacitinib and Lynparza 150 mg Tablet are taken together, the breakdown of Tofacitinib in the body may be reduced.

How to manage the interaction:
Although there is a possible interaction between Lynparza 150 mg Tablet and Tofacitinib, you can take these medicines together if prescribed by your doctor. It's better to be safe and get medical help if you have a fever, chills, diarrhea, sore throat, muscle aches, trouble breathing, weight loss, or pain while urinating. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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OLAPARIB-150MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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OLAPARIB-150MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Lynparza 150 mg Tablet levels in the blood may rise if it is consumed with grapefruit juice. This may increase possibility of side effects include nausea, vomiting, diarrhea, indigestion, appetite loss, abdominal pain or discomfort. Avoid the consumption of grapefruit juice along with Lynparza 150 mg Tablet. If you’re experiencing nausea, vomiting, diarrhea, indigestion, appetite loss, abdominal pain or discomfort, contact the doctor immediately.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • AMPRENAVIR
  • DARUNAVIR
  • APREPITANT
  • BCG VACCINE
  • DENGUE VACCINE
  • MUMPS (LIVE ATTENUATED)
  • CIPROFLOXACIN
  • FLUCONAZOLE
  • ITRACONAZOLE

Habit Forming

No

Special Advise

  • Pregnancy testing is recommended for females of reproductive potential prior to initiating treatment with Lynparza 150Mg Tablet.
  • Lynparza 150Mg Tablet should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Lynparza 150Mg Tablet.
  • Monitor complete blood count for cytopenia at baseline and monthly for clinically significant changes during treatment.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count in your blood.
  • Peripheral blood counts should be frequently monitored during Lynparza 150Mg Tablet treatment and, when appropriate, until recovery is achieved.
  • Do not donate sperm during treatment with Lynparza 150Mg Tablet for three months after your last dose.

Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs and added sugars.

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