Istamet XR CP Combipack

Istamet XR CP Combipack is a combination drug of Sitagliptin (DPP4 inhibitors) and Metformin (Biguanides) belongs to the class of anti-diabetic. Type 2 diabetes is a condition in which either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood) or there is resistance to the action of insulin. As a result, insulin is produced in large amounts but it is not able to act on the organs of the body.

Sitagliptin belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors which works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Another medicine Metformin belongs to the class of biguanides which lowers glucose production in the liver, delays glucose absorption from intestines and increases the body's sensitivity to insulin. Together, it prevents blood glucose levels from rising to very high levels after meals.

Istamet XR CP Combipack should be taken with food to avoid an upset stomach. Istamet XR CP Combipack should be taken at the same time of the day each time for best results. For better advice, your doctor will decide, what dose should be taken and it can change timely depending upon your condition. The most common side effect of Istamet XR CP Combipack is hypoglycemia (low blood glucose levels) characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth and skin etc. So, to avoid hypoglycemia, you should not miss meals and also should carry some form of sugar along with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, upper respiratory symptoms.

Istamet XR CP Combipack should not be stopped even if you feel better, without consulting your doctor as sugar level keeps changing. If you stop taking Istamet XR CP Combipack abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Istamet XR CP Combipack should not be taken if you have type 1 diabetes mellitus, severe kidney or liver disease. Please inform your doctor if you have any type of heart disease, is or planning to get pregnant or breastfeeding.

 Istamet XR CP Combipack helps your pancreas to produce more insulin, make effective utilization of insulin, and decreases excess of sugar that your liver makes. It helps in controlling rise of blood sugar level in your body after meal. Besides this, it does not cause weight gain in the prolonged use. Istamet XR CP Combipack plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

Swallow it as a whole with water; do not crush, break or chew it.

• Low blood sugar

• Runny nose

• Sore throat

• Upper lung infection

• Diarrhoea

• Nausea

• Vomiting

• Gas

• Stomach upset

• Indigestion

• General weakness

• Headache

Istamet XR CP Combipack should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. Some diabetic patients, while taking Istamet XR CP Combipack , might develop a rare but serious condition called lactic acidosis. In this condition, too much lactic acid is accumulated in the blood, which can damage the working of your liver and kidney required to eliminate excess lactic acid from the blood. Before you start taking Istamet XR CP Combipack , tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, and low vitamin B12 levels. Istamet XR CP Combipack , when used with insulin, Istamet XR CP Combipack may lower the blood sugar level, leading to hypoglycaemia, which can be fatal. In this case, your doctor may adjust the dose by lowering the insulin dose or Istamet XR CP Combipack . Prolonged intake of Istamet XR CP Combipack may lower your thyroid-stimulating hormone (TSH); hence, an annual check-up of TSH is recommended. In rare cases, you may also develop a serious skin reaction known as bullous pemphigoid that requires immediate medical attention. Tell your doctor if you are going to have a diagnostic test with an injection of dye or X-ray contrast agent. You should stop using Istamet XR CP Combipack for a short time before an X-ray procedure.

• BUPROPION
• CEPHALEXIN
• CIPROFLOXACIN
• CIMETIDINE
• DIGOXIN
• DOLUTEGRAVIR
• GLYCOPYRROLATE
• TOPIRAMATE
• LAMOTRIGINE
• RANOLAZINE
• ALPHA LIPOIC ACID
• ASPIRIN
• PROTHIONAMIDE
• PEGVISOMANT

• Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.
• Eat at regular intervals. Do not take a long gap between a meal or snack.
• Monitor your blood sugar level regularly especially when there are lots of fluctuations.
• Invest at least 150 min of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
• Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
• Replace refined carbohydrates-containing foods with whole grain foods and increase the intake of fruits and veggies and other fibre-enriched foods.
• Reduce intake of saturated fat (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
• Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
• Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
• Keep your blood pressure as normal (140/90) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.