Exena-50 Tablet 10'S

Exena-50 Tablet 10'S belongs to the group of medications called ‘urinary antagonists' or 'antispasmodics' primarily used in the treatment of overactive bladder (OAB) symptoms. Overactive bladder is a condition in which the urinary bladder muscles constrict uncontrollably, thereby causing an urgent need to urinate, frequent urination and inability to control urination.

Exena-50 Tablet 10'S contains ‘mirabegron’ that relaxes the urinary bladder muscles, which in turn decreases the activity of the overactive bladder. In an overactive bladder, muscle contractions occur before the full expansion of the bladder, causing the patient to have frequent urges to urinate. Exena-50 Tablet 10'S stops these sudden contractions of urinary bladder muscles, thereby enabling control over urination. Thus, it increases the amount and volume of urine that can be held by the bladder.

In some cases, Exena-50 Tablet 10'S may cause common side effects of Exena-50 Tablet 10'S are nausea, constipation, diarrhoea, headache, dizziness, and increased heart rate. Most of these side effects do not require medical attention and resolve gradually over time. However, if the side effects persist or worsen, consult a doctor.

Do not take Exena-50 Tablet 10'S if you are allergic to any of its ingredients. Before taking Exena-50 Tablet 10'S, inform your doctor if you have kidney disease, liver disease, hypertension, urinary retention, angioedema, or a history of heart rhythm problems (including QT prolongation). Consult your doctor if you are pregnant or breastfeeding. Avoid driving or operating heavy machinery, as this medicine may cause dizziness.

Exena-50 Tablet 10'S contains 'mirabegron', which belongs to the class of medications called 'anticholinergics'. It can decrease the activity of the overactive bladder. In an overactive bladder, muscle contractions occur before the full expansion of the bladder, causing the patient to have frequent urges to urinate. Exena-50 Tablet 10'S can stop these sudden contractions of bladder muscles. It enables control over urination and increases the amount of urine held by your bladder.

• Nausea
• Constipation
• Diarrhoea
• Headache
• Dizziness
• Increased heart rate

Do not take Exena-50 Tablet 10'S if you are allergic to any ingredients present in it. Before taking Exena-50 Tablet 10'S, inform your doctor if you have kidney disease, liver disease, hypertension, urinary retention, angioedema, or a history of heart rhythm problems (including QT prolongation). Consult your doctor if you are pregnant or breastfeeding. Avoid driving or operating heavy machinery, as this medicine may cause dizziness.

Drug-Drug Interactions: Exena-50 Tablet 10'S may interact with other antifungal drugs (ketoconazole and itraconazole), antihypertensives (carvedilol, metoprolol), antacid (brexpiprazole), anti-psychotic (pimozide, thioridazine),  anti-allergic (chlorpheniramine), anti-tussive (dextromethorphan), blood thinners (warfarin, coumadin), anti-depressants (desipramine), anti-arrhythmic (digoxin, flecainide, propafenone), drugs used to treat overactive bladder (darifenacin, fesoterodine, oxybutynin, tolterodine, trospium).

Drug-Food Interactions: Do not take grapefruit or grapefruit juice while using Exena-50 Tablet 10'S.

Drug-Disease Interactions: Exena-50 Tablet 10'S should be used with caution in patients with urinary retention (inability to urinate), heart rhythm problems (including QT prolongation), hypertension, kidney dialysis, severe liver disease, or severe kidney disease.

• KETOCONAZOLE
• ITRACONAZOLE
• CARVEDILOL
• METOPROLOL
• PIMOZIDE
• THIORIDAZINE
• CHLORPHENIRAMINE
• DEXTROMETHORPHAN
• WARFARIN
• COUMADIN
• DESIPRAMINE
• DIGOXIN
• FLECAINIDE
• PROPAFENONE
• DARIFENACIN
• FESOTERODINE
• OXYBUTYNIN
• TOLTERODINE
• TROSPIUM

• Eat fresh fruits like pears, bananas, citrus fruits, and vegetables like beans and potatoes. 
• Try to take cranberry juice as it helps in minimizing urinary infections. 
• Avoid coffee, tea, and carbonated drinks which contain caffeine. 
• Do not consume processed, fried, or spicy foods, as these can irritate your bladder. 
• Limit alcohol intake as it can increase the risk of side effects.
• Quit smoking and exercise regularly.

• Exena-50 Tablet 10'S may raise your blood pressure. Monitor your blood pressure regularly.

Overactive bladder (OAB): In normal conditions, when the urinary bladder is filled with urine, it sends a message to the brain that an individual is ready to urinate. During the urination process, bladder muscles contract, which ultimately leads to a uniform flow of urine. Contrary to this, in an overactive bladder (OAB), the urinary bladder muscles start contracting before the urine is filled in the urinary bladder, thereby causing frequent urges to urinate.