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Composition :
CEFUROXIME-250MG+LACTOBACILLUS-120MILLION SPORES
Manufacturer/Marketer :
Apellon Biotech
Consume Type :
Oral
Expires on or after :
Return Policy :
Not Returnable
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Alcohol
Safe if prescribed
The interaction of Duocin 250 mg Tablet with alcohol is unknown. Please consult a doctor if you have any concerns.
Pregnancy
Consult your doctor
Duocin 250 mg Tablet is a pregnancy category B drug. It can be safely used in pregnancy only if prescribed by a doctor.
Breast Feeding
Consult your doctor
Caution should be exercised before taking Duocin 250 mg Tablet if you are breastfeeding. Your doctor will weigh the benefits and potential risks before prescribing this medicine to you.
Driving
Safe if prescribed
As this medicine may cause dizziness, patients should be warned to be cautious when driving or operating machinery.
Liver
Consult your doctor
Take Duocin 250 mg Tablet with caution, especially if you have a history of liver diseases. Please consult your doctor; your doctor may adjust the dose or prescribe a suitable alternative based on your condition.
Kidney
Consult your doctor
Take Duocin 250 mg Tablet with caution if you have a history of Kidney diseases. Please consult your doctor; your doctor may adjust the dose or prescribe a suitable alternative based on your condition.
Children
Safe if prescribed
Duocin 250 mg Tablet is not recommended for babies below three months of age as the safety and effectiveness were not established. It can be used in children above three months if prescribed by a doctor.
Product Substitutes
Drug-Drug Interactions
Severe
CefuroximeLepirudin
Severe
Drug-Drug Interactions
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Severe
How does the drug interact with Duocin 250 mg Tablet:
Co-administration of Dalteparin and Duocin 250 mg Tablet can increase the blood levels and effects of Dlateparin.
How to manage the interaction:
Taking Duocin 250 mg Tablet with Dalteparin together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Co-administration of Dalteparin and Duocin 250 mg Tablet can increase the blood levels and effects of Dlateparin.
How to manage the interaction:
Taking Duocin 250 mg Tablet with Dalteparin together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
CefuroximeLepirudin
Severe
How does the drug interact with Duocin 250 mg Tablet:
The therapeutic efficacy of Lepirudin can be decreased when used in combination with Duocin 250 mg Tablet.
How to manage the interaction:
Although taking Duocin 250 mg Tablet and Lepirudin together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without a doctor's advice.
The therapeutic efficacy of Lepirudin can be decreased when used in combination with Duocin 250 mg Tablet.
How to manage the interaction:
Although taking Duocin 250 mg Tablet and Lepirudin together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without a doctor's advice.
CefuroximeBCG vaccine
Severe
How does the drug interact with Duocin 250 mg Tablet:
Co-administration of Duocin 250 mg Tablet may reduce the anti-tumor activity of BCG in the bladder.
How to manage the interaction:
Talk to your doctor before receiving BCG if you are currently being treated with Duocin 250 mg Tablet. To ensure adequate response to your treatment, you should not receive BCG until after you complete your antibiotic therapy. Do not discontinue the medication without consulting a doctor.
Co-administration of Duocin 250 mg Tablet may reduce the anti-tumor activity of BCG in the bladder.
How to manage the interaction:
Talk to your doctor before receiving BCG if you are currently being treated with Duocin 250 mg Tablet. To ensure adequate response to your treatment, you should not receive BCG until after you complete your antibiotic therapy. Do not discontinue the medication without consulting a doctor.
Moderate
How does the drug interact with Duocin 250 mg Tablet:
Taking these medications together might make it harder for your body to absorb atazanavir, which could make it less effective.
How to manage the interaction:
vv
Taking these medications together might make it harder for your body to absorb atazanavir, which could make it less effective.
How to manage the interaction:
vv
Drug-Food Interactions
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.
Drug-Food Interactions
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Drug-Diseases Interactions
CEFUROXIME-250MG+LACTOBACILLUS-120MILLION SPORESOther gastroenteritis and colitis of infectious and unspecified origin
Severe
CEFUROXIME-250MG+LACTOBACILLUS-120MILLION SPORESChronic kidney disease
Moderate
Drug-Diseases Interactions
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CEFUROXIME-250MG+LACTOBACILLUS-120MILLION SPORESOther gastroenteritis and colitis of infectious and unspecified origin
Severe
How does the disease interact with Duocin 250 mg Tablet:
Colitis: In some cases the use of Duocin 250 mg Tablet may cause ranging from mild diarrhea to fatal colitis. Colitis is commonly Clostridioides difficile-associated diarrhea (CDAD). Discontinue therapy if signs of CDAD are confirmed.
How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Duocin 250 mg Tablet should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the colon) or pseudomembranous colitis (a severe inflammation of the inner lining of the large intestine). Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
Colitis: In some cases the use of Duocin 250 mg Tablet may cause ranging from mild diarrhea to fatal colitis. Colitis is commonly Clostridioides difficile-associated diarrhea (CDAD). Discontinue therapy if signs of CDAD are confirmed.
How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Duocin 250 mg Tablet should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the colon) or pseudomembranous colitis (a severe inflammation of the inner lining of the large intestine). Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
CEFUROXIME-250MG+LACTOBACILLUS-120MILLION SPORESChronic kidney disease
Moderate
How does the disease interact with Duocin 250 mg Tablet:
Renal dysfunction: Duocin 250 mg Tablet is eliminated by the kidney in an unchanged form. Thus the plasma levels of the drug increase and prolongs the half-life. Adjust the doses of Duocin 250 mg Tablet as necessary.
How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function as most beta-lactam antibiotics are eliminated by the kidney. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised during prolonged or high-dose therapy.
Renal dysfunction: Duocin 250 mg Tablet is eliminated by the kidney in an unchanged form. Thus the plasma levels of the drug increase and prolongs the half-life. Adjust the doses of Duocin 250 mg Tablet as necessary.
How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function as most beta-lactam antibiotics are eliminated by the kidney. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised during prolonged or high-dose therapy.
CEFUROXIME-250MG+LACTOBACILLUS-120MILLION SPORESDependence on enabling machines and devices, not elsewhere classified
Moderate
How does the disease interact with Duocin 250 mg Tablet:
Dialysis : Most of the antibiotics are eliminated by hemodialysis. Therefore, administer Duocin 250 mg Tablet after dialysis or an additional dosage to be administered.
How to manage the interaction:
Duocin 250 mg Tablet serum levels may be decreased by hemodialysis and peritoneal dialysis. Supplemental doses should be given at the end of each hemodialysis session.
Dialysis : Most of the antibiotics are eliminated by hemodialysis. Therefore, administer Duocin 250 mg Tablet after dialysis or an additional dosage to be administered.
How to manage the interaction:
Duocin 250 mg Tablet serum levels may be decreased by hemodialysis and peritoneal dialysis. Supplemental doses should be given at the end of each hemodialysis session.
CEFUROXIME-250MG+LACTOBACILLUS-120MILLION SPORESConvulsions, not elsewhere classified
Moderate
How does the disease interact with Duocin 250 mg Tablet:
seizure disorders: In some patients, seizures were reported with whom renal dysfunction which incase of dosage adjustment was not done. Discontinue Duocin 250 mg Tablet if seizures are reported.
How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Duocin 250 mg Tablet should be discontinued if seizures associated with drug therapy occur.
seizure disorders: In some patients, seizures were reported with whom renal dysfunction which incase of dosage adjustment was not done. Discontinue Duocin 250 mg Tablet if seizures are reported.
How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Duocin 250 mg Tablet should be discontinued if seizures associated with drug therapy occur.
CEFUROXIME-250MG+LACTOBACILLUS-120MILLION SPORESOther diseases of liver
Moderate
How does the disease interact with Duocin 250 mg Tablet:
liver disease: With Duocin 250 mg Tablet, a transient increase in the AST, ALT, and alkaline phosphatase levels was observed. Use with caution and closely monitor for hepatic function is recommended.
How to manage the interaction:
Caution and monitoring is recommended in patients with liver disease as cases of hepatitis have been reported with the use of certain cephalosporins.
liver disease: With Duocin 250 mg Tablet, a transient increase in the AST, ALT, and alkaline phosphatase levels was observed. Use with caution and closely monitor for hepatic function is recommended.
How to manage the interaction:
Caution and monitoring is recommended in patients with liver disease as cases of hepatitis have been reported with the use of certain cephalosporins.
CEFUROXIME-250MG+LACTOBACILLUS-120MILLION SPORESOther diseases of liver
Moderate
How does the disease interact with Duocin 250 mg Tablet:
Rarely, cephalosporins use may cause hypoprothrombinemia, with or without bleeding. Monitor for Prothrombin time.
How to manage the interaction:
Cephalosporins may be associated with reduced prothrombin activity/prolonged prothrombin time (blood takes too long to form a clot). Prothrombin time should be monitored in at-risk patients and managed as needed.
Rarely, cephalosporins use may cause hypoprothrombinemia, with or without bleeding. Monitor for Prothrombin time.
How to manage the interaction:
Cephalosporins may be associated with reduced prothrombin activity/prolonged prothrombin time (blood takes too long to form a clot). Prothrombin time should be monitored in at-risk patients and managed as needed.
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