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  1. Home
  2. Medicine

  3. Doxific Injection

Prescription drug
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy

Composition :

DOXYCYCLINE-100MG

Manufacturer/Marketer :

Gufic Bioscience Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIBIOTICS

Country of origin

INDIA

Manufacturer/Marketer address

37,1st Floor, Kamala Bhavan II, Swami Nityanand Road, Andheri (East), Mumbai - 400 069. (INDIA)
Other Info - DOX0268

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 8, 2025 | 9:45 AM IST

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Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

It is not known if alcohol affects Doxific Injection. Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Doxific Injection belongs to pregnancy category D. There are no adequate and well-controlled studies on the use of Doxific Injection in pregnant women. In some cases, taking Doxific Injection during pregnancy may affect tooth and bone development in the unborn baby. So, if you are pregnant or planning for pregnancy contact the doctor before using Doxific Injection.

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Breast Feeding

Caution

Doxific Injection is excreted in the breast milk. However, the extent of absorption of Doxific Injection by the breastfed infant is not known. Hence, the nursing mother should consult the doctor before using Doxific Injection.

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Driving

Caution

It is not known if Doxific Injection affects your ability to drive. Drive or operate machinery only if you are alert.

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Liver

Caution

Doxific Injection is to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Safe if prescribed

At the recommended doses, Doxific Injection is safe to use in patients with kidney disease if prescribed by a doctor.

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Children

Caution

Use of Doxific Injection during tooth development in infants and children below 8 years of age may cause permanent staining of teeth (yellow-grey-brown). So, it is not recommended for children below 8 years of age.

Product Substitutes

Reference

  1. https://www.medicines.org.uk/emc/files/pil.4063.pdf
  2. https://medlineplus.gov/druginfo/meds/a601141.html
  3. https://www.drugs.com/cdi/doxycycline-injection.html

About Doxific Injection

Doxific Injection belongs to a group of medications called tetracycline antibiotics used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections (gonorrhoea, syphilis), and gum infections (periodontitis). Besides this, Doxific Injection may also be used to treat or prevent anthrax.

Doxific Injection contains 'Doxycycline' which stops the growth of bacteria by preventing the synthesis of essential proteins necessary for their survival. Thereby, Doxific Injection helps treat bacterial infections. It is a broad-spectrum antibiotic which is effective against both gram-negative and gram-positive bacteria.

Doxific Injection will be administered by a healthcare professional; do not self-administer. In some cases, Doxific Injection may cause pain, itching, swelling or redness at the site of injection, nausea, vomiting, or diarrhoea. Most of these side effects of Doxific Injection do not require medical attention and gradually resolve over time. Please consult your doctor if these side effects become troublesome.

Do not take Doxific Injection if you are allergic to any of the components. Consult your doctor if you are pregnant or breastfeeding. Use of Doxific Injection during tooth development (last half of pregnancy, infancy, and in children below 8 years) may cause teeth staining (yellow-grey-brown). Keep your doctor informed about your health condition and medications to rule out any interactions/side effects.

Uses of Doxific Injection

Bacterial infections

Medicinal Benefits Mweb

Medicinal Benefits

Doxific Injection belongs to the class of medicines called tetracycline antibiotics which is effective against a wide range of bacteria, including gram-negative, gram-positive bacteria, anaerobes, and some parasites. It is used to treat respiratory tract infections (influenza, pneumonia), genitourinary infections (syphilis, gonorrhoea), anthrax infection, sinuses, eye, and skin infections. Besides this, it is also indicated in the tick-borne infections (typhus fever) caused by the Rickettsia group of bacteria like typhus fever. Off-label, usage includes the prevention of malaria and the treatment of acne.

Directions for Use

Doxific Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Side Effects of Doxific Injection

  • Pain, itching, swelling or redness at the site of injection
  • Nausea
  • Vomiting
  • Diarrhoea

Drug Warnings

Do not take Doxific Injection if you are allergic to any of its contents. Inform your doctor if you have lupus, or if you are pregnant or breastfeeding.  Use of Doxific Injection during tooth development (last half of pregnancy, infancy, and in children below 8 years) may cause teeth staining (yellow-grey-brown). Consult your doctor if you experience any skin reactions, fever,  muscle, or joint problems.

Drug-Drug Interactions

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DoxycyclineAcitretin
Critical
DoxycyclineTretinoin
Critical

Drug-Drug Interactions

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DoxycyclineAcitretin
Critical
How does the drug interact with Doxific Injection:
Coadministration of Acitretin with Doxific Injection can increase the risk and severity of vision problems.

How to manage the interaction:
Taking Acitretin with Doxific Injection together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxycyclineTretinoin
Critical
How does the drug interact with Doxific Injection:
Coadministration of Tretinoin with Doxific Injection can increase the risk of side effects like vision problems.

How to manage the interaction:
Taking Tretinoin with Doxific Injection is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden headache, nausea, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxycyclineIsotretinoin
Critical
How does the drug interact with Doxific Injection:
Taking isotretinoin with Doxific Injection may increase the risk of a rare condition called pseudotumor cerebri (increased pressure in the brain).

How to manage the interaction:
Although taking isotretinoin and Doxific Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, nausea, vomiting, and visual disturbances, consult a doctor. Do not stop using any medications without consulting doctor.
DoxycyclineEtretinate
Critical
How does the drug interact with Doxific Injection:
Taking Doxific Injection with etretinate may increase the risk of vision problems.

How to manage the interaction:
Taking Etretinate with Doxific Injection is not recommended, but can be taken if prescribed by a doctor. However, consult a doctor if you experience headache, nausea, vomiting, and visual disturbances. Do not discontinue any medication without consulting a doctor.
DoxycyclineCalcium acetate
Severe
How does the drug interact with Doxific Injection:
Co-administration of Doxific Injection with calcium acetate can reduce its effectiveness.

How to manage the interaction:
Although there is an interaction between calcium acetate and Doxific Injection, it can be taken together if prescribed by a doctor. It is adviced to take Doxific Injection 2 hrs before or 6 hours after taking calcium acetate. Do not stop using any medications without talking to a doctor.
DoxycyclineAminolevulinic acid
Severe
How does the drug interact with Doxific Injection:
Co-administration of aminolevulinic acid with Doxific Injection may increase the risk of sunburn.

How to manage the interaction:
Co-administration of Doxific Injection with Aminolevulinic acid can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice that your skin is very sensitive to sunlight or if you have a sunburn, it's important to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
DoxycyclineLomitapide
Severe
How does the drug interact with Doxific Injection:
Coadministration of lomitapide with Doxific Injection can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Doxific Injection and Lomitapide, but it can be taken if prescribed by a doctor. However, contact your doctor if you experience fever, chills, joint pain, swelling, skin rash, itching, feeling tired, feeling sick, stomach ache, and dark urine. Do not stop using any medications without first talking to your doctor.
DoxycyclineKetoconazole
Severe
How does the drug interact with Doxific Injection:
Coadministration of Ketoconazole and Doxific Injection may increase the risk of liver problems.

How to manage the interaction:
Although taking Doxific Injection with Ketoconazole can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience any symptoms such as joint pain or swelling, skin rash, itching, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue using any medications without consulting a doctor.
DoxycyclineMipomersen
Severe
How does the drug interact with Doxific Injection:
Taking Doxific Injection with mipomersen may increase the risk of liver problems.

How to manage the interaction:
Although taking Doxific Injection with Mipomersen can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any symptoms such as joint pain or swelling, skin rash, itching, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue using any medications without consulting a doctor.
DoxycyclineRetinol (vit a)
Severe
How does the drug interact with Doxific Injection:
Taking vitamin A with Doxific Injection may increase the risk of vision problems.

How to manage the interaction:
Although taking Retinol (vitamin A) together with Doxific Injection can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue using any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ACITRETIN
  • ISOTRETINOIN
  • WARFARIN
  • DIGOXIN
  • PHENYTOIN
  • CARBAMAZEPINE
  • ALUMINIUM
  • CALCIUM
  • MAGNESIUM
  • BISMUTH SUBSALICYLATE

Habit Forming

No

Special Advise

  • Wear sunglasses and sunscreen when you go out in the sun as Doxific Injection can make your skin sensitive to light.
  • Maintain a gap of 2 hours between Doxific Injection and iron supplements and antacids as taking them together might affect the working of Doxific Injection.
  • Doxific Injection might affect certain lab tests, inform the person doing the tests that you are taking Doxific Injection.

Diet & Lifestyle Advise

  • It would be best to take probiotics after completing the full course of Doxific Injection to restore healthy bacteria in the intestine that may have been killed due to the usage of antibiotics. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yogurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Whole-grain bread, and brown rice, should be included in your diet.
  • Avoid taking too much calcium enriched foods and drinks as it might affect the working of Doxific Injection.
  • Avoid intake of alcoholic beverages with Doxific Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid Doxific Injection in fighting off infections.

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