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  1. Home
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  3. Difidox-HD 200 mg Injection

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy

Composition :

DOXYCYCLINE-200MG

Manufacturer/Marketer :

Fusion Health Care Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Return Policy :

Not Returnable

Therapeutic Class

[ANTIBIOTICS]

Country of origin

India

Manufacturer/Marketer address

Fusion House, Plot No. 22, H.No 8-2-350/B, Road No. 3, Banjara Hills, Hyderabad, Telangana-500034
Other Info - DIF0038

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 8, 2025 | 9:45 AM IST

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FAQs

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Safe if prescribed

It is not known if alcohol affects Difidox-HD 200 mg Injection. Please consult your doctor if you have any concerns.

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Pregnancy

Consult your doctor

Difidox-HD 200 mg Injection belongs to pregnancy category D. There are no adequate and well-controlled studies on the use of Difidox-HD 200 mg Injection in pregnant women. In some cases, taking Difidox-HD 200 mg Injection during pregnancy may affect tooth and bone development in the unborn baby. So, if you are pregnant or planning for pregnancy contact the doctor before using Difidox-HD 200 mg Injection.

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Breast Feeding

Consult your doctor

Difidox-HD 200 mg Injection is excreted in the breast milk. However, the extent of absorption of Difidox-HD 200 mg Injection by the breastfed infant is not known. Hence, the nursing mother should consult the doctor before using Difidox-HD 200 mg Injection.

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Driving

Safe if prescribed

It is not known if Difidox-HD 200 mg Injection affects your ability to drive. Drive or operate machinery only if you are alert.

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Liver

Consult your doctor

Difidox-HD 200 mg Injection is to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Consult your doctor

At the recommended doses, Difidox-HD 200 mg Injection is safe to use in patients with kidney disease if prescribed by a doctor.

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Children

Safe if prescribed

Use of Difidox-HD 200 mg Injection during tooth development in infants and children below 8 years of age may cause permanent staining of teeth (yellow-grey-brown). So, it is not recommended for children below 8 years of age.

Reference

  1. https://www.medicines.org.uk/emc/files/pil.4063.pdf
  2. https://medlineplus.gov/druginfo/meds/a601141.html
  3. https://www.drugs.com/cdi/doxycycline-injection.html

About Difidox-HD 200 mg Injection

Difidox-HD 200 mg Injection belongs to a group of medications called tetracycline antibiotics used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections (gonorrhoea, syphilis), and gum infections (periodontitis). Besides this, Difidox-HD 200 mg Injection may also be used to treat or prevent anthrax.

Difidox-HD 200 mg Injection contains 'Doxycycline' which stops the growth of bacteria by preventing the synthesis of essential proteins necessary for their survival. Thereby, Difidox-HD 200 mg Injection helps treat bacterial infections. It is a broad-spectrum antibiotic which is effective against both gram-negative and gram-positive bacteria.

Difidox-HD 200 mg Injection will be administered by a healthcare professional; do not self-administer. In some cases, Difidox-HD 200 mg Injection may cause pain, itching, swelling or redness at the site of injection, nausea, vomiting, or diarrhoea. Most of these side effects of Difidox-HD 200 mg Injection do not require medical attention and gradually resolve over time. Please consult your doctor if these side effects become troublesome.

Do not take Difidox-HD 200 mg Injection if you are allergic to any of the components. Consult your doctor if you are pregnant or breastfeeding. Use of Difidox-HD 200 mg Injection during tooth development (last half of pregnancy, infancy, and in children below 8 years) may cause teeth staining (yellow-grey-brown). Keep your doctor informed about your health condition and medications to rule out any interactions/side effects.

Uses of Difidox-HD 200 mg Injection

Bacterial infections

Medicinal Benefits Mweb

Key Benefits

Difidox-HD 200 mg Injection belongs to the class of medicines called tetracycline antibiotics which is effective against a wide range of bacteria, including gram-negative, gram-positive bacteria, anaerobes, and some parasites. It is used to treat respiratory tract infections (influenza, pneumonia), genitourinary infections (syphilis, gonorrhoea), anthrax infection, sinuses, eye, and skin infections. Besides this, it is also indicated in the tick-borne infections (typhus fever) caused by the Rickettsia group of bacteria like typhus fever. Off-label, usage includes the prevention of malaria and the treatment of acne.

Directions for Use

Difidox-HD 200 mg Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Side Effects of Difidox-HD 200 mg Injection

  • Pain, itching, swelling or redness at the site of injection
  • Nausea
  • Vomiting
  • Diarrhoea

Drug Warnings

Do not take Difidox-HD 200 mg Injection if you are allergic to any of its contents. Inform your doctor if you have lupus, or if you are pregnant or breastfeeding.  Use of Difidox-HD 200 mg Injection during tooth development (last half of pregnancy, infancy, and in children below 8 years) may cause teeth staining (yellow-grey-brown). Consult your doctor if you experience any skin reactions, fever,  muscle, or joint problems.

Drug-Drug Interactions

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DoxycyclineAcitretin
Critical
DoxycyclineTretinoin
Critical

Drug-Drug Interactions

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DoxycyclineAcitretin
Critical
How does the drug interact with Difidox-HD 200 mg Injection:
Coadministration of Acitretin with Difidox-HD 200 mg Injection can increase the risk and severity of vision problems.

How to manage the interaction:
Taking Acitretin with Difidox-HD 200 mg Injection together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxycyclineTretinoin
Critical
How does the drug interact with Difidox-HD 200 mg Injection:
Coadministration of Tretinoin with Difidox-HD 200 mg Injection can increase the risk of side effects like vision problems.

How to manage the interaction:
Taking Tretinoin with Difidox-HD 200 mg Injection is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden headache, nausea, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxycyclineIsotretinoin
Critical
How does the drug interact with Difidox-HD 200 mg Injection:
Taking isotretinoin with Difidox-HD 200 mg Injection may increase the risk of a rare condition called pseudotumor cerebri (increased pressure in the brain).

How to manage the interaction:
Although taking isotretinoin and Difidox-HD 200 mg Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, nausea, vomiting, and visual disturbances, consult a doctor. Do not stop using any medications without consulting doctor.
DoxycyclineEtretinate
Critical
How does the drug interact with Difidox-HD 200 mg Injection:
Taking Difidox-HD 200 mg Injection with etretinate may increase the risk of vision problems.

How to manage the interaction:
Taking Etretinate with Difidox-HD 200 mg Injection is not recommended, but can be taken if prescribed by a doctor. However, consult a doctor if you experience headache, nausea, vomiting, and visual disturbances. Do not discontinue any medication without consulting a doctor.
DoxycyclineCalcium acetate
Severe
How does the drug interact with Difidox-HD 200 mg Injection:
Co-administration of Difidox-HD 200 mg Injection with calcium acetate can reduce its effectiveness.

How to manage the interaction:
Although there is an interaction between calcium acetate and Difidox-HD 200 mg Injection, it can be taken together if prescribed by a doctor. It is adviced to take Difidox-HD 200 mg Injection 2 hrs before or 6 hours after taking calcium acetate. Do not stop using any medications without talking to a doctor.
DoxycyclineAminolevulinic acid
Severe
How does the drug interact with Difidox-HD 200 mg Injection:
Co-administration of aminolevulinic acid with Difidox-HD 200 mg Injection may increase the risk of sunburn.

How to manage the interaction:
Co-administration of Difidox-HD 200 mg Injection with Aminolevulinic acid can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice that your skin is very sensitive to sunlight or if you have a sunburn, it's important to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
DoxycyclineLomitapide
Severe
How does the drug interact with Difidox-HD 200 mg Injection:
Coadministration of lomitapide with Difidox-HD 200 mg Injection can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Difidox-HD 200 mg Injection and Lomitapide, but it can be taken if prescribed by a doctor. However, contact your doctor if you experience fever, chills, joint pain, swelling, skin rash, itching, feeling tired, feeling sick, stomach ache, and dark urine. Do not stop using any medications without first talking to your doctor.
DoxycyclineKetoconazole
Severe
How does the drug interact with Difidox-HD 200 mg Injection:
Coadministration of Ketoconazole and Difidox-HD 200 mg Injection may increase the risk of liver problems.

How to manage the interaction:
Although taking Difidox-HD 200 mg Injection with Ketoconazole can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience any symptoms such as joint pain or swelling, skin rash, itching, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue using any medications without consulting a doctor.
DoxycyclineMipomersen
Severe
How does the drug interact with Difidox-HD 200 mg Injection:
Taking Difidox-HD 200 mg Injection with mipomersen may increase the risk of liver problems.

How to manage the interaction:
Although taking Difidox-HD 200 mg Injection with Mipomersen can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any symptoms such as joint pain or swelling, skin rash, itching, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue using any medications without consulting a doctor.
DoxycyclineRetinol (vit a)
Severe
How does the drug interact with Difidox-HD 200 mg Injection:
Taking vitamin A with Difidox-HD 200 mg Injection may increase the risk of vision problems.

How to manage the interaction:
Although taking Retinol (vitamin A) together with Difidox-HD 200 mg Injection can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue using any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ACITRETIN
  • ISOTRETINOIN
  • WARFARIN
  • DIGOXIN
  • PHENYTOIN
  • CARBAMAZEPINE
  • ALUMINIUM
  • CALCIUM
  • MAGNESIUM
  • BISMUTH SUBSALICYLATE

Habit Forming

No

Special Advise

  • Wear sunglasses and sunscreen when you go out in the sun as Difidox-HD 200 mg Injection can make your skin sensitive to light.
  • Maintain a gap of 2 hours between Difidox-HD 200 mg Injection and iron supplements and antacids as taking them together might affect the working of Difidox-HD 200 mg Injection.
  • Difidox-HD 200 mg Injection might affect certain lab tests, inform the person doing the tests that you are taking Difidox-HD 200 mg Injection.

Diet & Lifestyle Advise

  • It would be best to take probiotics after completing the full course of Difidox-HD 200 mg Injection to restore healthy bacteria in the intestine that may have been killed due to the usage of antibiotics. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yogurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Whole-grain bread, and brown rice, should be included in your diet.
  • Avoid taking too much calcium enriched foods and drinks as it might affect the working of Difidox-HD 200 mg Injection.
  • Avoid intake of alcoholic beverages with Difidox-HD 200 mg Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid Difidox-HD 200 mg Injection in fighting off infections.

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