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  1. Home
  2. Medicine

  3. Defrijet 500 Tablet 10's

Prescription drug
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Hari Kumar , MBBS

Composition :

DEFERASIROX-500MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

CHELATING AGENTS

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - DEF0068

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Hari Kumar

Reviewed By

Hari Kumar

MBBS

Last Updated

Jul 8, 2025 | 9:41 AM IST

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FAQs

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Consume alcohol along with Defrijet 500 Tablet is not advisable as it may cause unpleasant side effects, or you also may become more sensitive to the effects of alcohol.

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Pregnancy

Caution

Defrijet 500 Tablet is not usually recommended if you are pregnant. This is because there is not enough information to say whether it's safe. However, your doctor may prescribe it if they think the benefits of the medicine outweigh the risks. Please consult the doctor.

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Breast Feeding

Caution

Defrijet 500 Tablet is not usually recommended if you are a lactating woman. This is because there is not enough information to say whether it's safe. However, your doctor may prescribe it if they think the benefits of the medicine outweigh the risks.

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Driving

Caution

It is not known whether Defrijet 500 Tablet alters the ability to drive, so do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react.

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Liver

Caution

Should exercise caution, and it is advisable to consult a doctor before using it. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Should exercise caution, and it is advisable to consult a doctor before using it. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

Should be used under the supervision of healthcare provider

Product Substitutes

Reference

  1. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=207968
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/207968s009lbl.pdf

About Defrijet 500 Tablet

Defrijet 500 Tablet belongs to the group of medicines called iron chelators. Defrijet 500 Tablet is indicated for treating chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients two years older. It can also be indicated for treating chronic iron overload in patients ten years of age and older with non-transfusion-dependent thalassemia (NTDT).

The active ingredient in Defrijet 500 Tablet is deferasirox. It is a trivalent iron selective chelating agent. It binds the excess iron and eliminates it through faeces. The danger of organ damage is reduced as a result.

Defrijet 500 Tablet is available in the form of oral formulations. Please take Defrijet 500 Tablet in the dose and duration prescribed by your doctor based on specific medical conditions. In some cases, you may experience common side effects such as diarrhoea, vomiting, nausea, abdominal pain, skin rashes, and increased serum creatinine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue using Defrijet 500 Tablet for as long as your doctor has prescribed it. Do not use Defrijet 500 Tablet without a doctor's advice if you have a skin reaction or irritation to any medicine. Consult your doctor before using the Defrijet 500 Tablet if you are pregnant or breastfeeding. Do not use Defrijet 500 Tablet in more than prescribed doses or longer duration as it may cause adverse effects. Keep your doctor informed about your health condition and all the medicines you take before taking Defrijet 500 Tablet to rule out any side effects.

Uses of Defrijet 500 Tablet

Defrijet 500 Tablet is indicated for treating chronic iron overload that occurs due to blood transfusions (transfusional hemosiderosis) in patients two years of age and older. It can also be indicated for treating chronic iron overload in patients ten years of age and older with non-transfusion-dependent thalassemia (NTDT).

Medicinal Benefits Mweb

Medicinal Benefits

Deferasirox is the active component in Defrijet 500 Tablet . It's a chelating agent that selectively binds to trivalent iron. It binds extra iron and excretes it in the faeces. As a result, the risk of organ damage is lowered.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.

Side Effects of Defrijet 500 Tablet

  • Diarrhea
  • Vomiting
  • Nausea
  • Abdominal Pain
  • Skin Rashes
  • Increases in Serum Creatinine

Drug Warnings

Do not take Defrijet 500 Tablet if you are allergic to Defrijet 500 Tablet or its ingredients. Defrijet 500 Tablet is not usually recommended if you are a pregnant or lactating woman; there is not enough information to say whether it's safe. However, your doctor may prescribe it if they think the medicine's benefits outweigh the risks. It is unknown whether Defrijet 500 Tablet alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react. Seek medical attention if the symptoms persist longer. Avoid consuming alcohol along with Defrijet 500 Tablet as it could lead to unpleasant side effects. Should monitor elderly and paediatric patients closely for toxicity.

Drug-Drug Interactions

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DeferasiroxStreptomycin
Severe
DeferasiroxDeflazacort
Severe

Drug-Drug Interactions

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DeferasiroxStreptomycin
Severe
How does the drug interact with Defrijet 500 Tablet:
Coadministration of Defrijet 500 Tablet and Streptomycin can increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Defrijet 500 Tablet and Streptomycin together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience a fast heartbeat, anxiety, constipation, cough, dark urine, diarrhea, dizziness, lightheadedness, fainting, fever, hives or welts, itching skin or rash consult a doctor. Do not discontinue any medications without consulting a doctor.
DeferasiroxDeflazacort
Severe
How does the drug interact with Defrijet 500 Tablet:
Using Defrijet 500 Tablet together with Deflazacort may increase the risk of gastric and intestinal ulcers and bleeding.

How to manage the interaction:
Co-administration of Defrijet 500 Tablet with Deflazacort can result in an interaction, but it can be taken if your doctor has advised it. If you have any symptoms like stomach pain, dizziness, loss of appetite, nausea, vomiting, or black or tarry stools, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
DeferasiroxVorapaxar
Severe
How does the drug interact with Defrijet 500 Tablet:
Using Defrijet 500 Tablet together with Vorapaxar may increase the risk of gastrointestinal ulcers.

How to manage the interaction:
Co-administration of Vorapaxar with Defrijet 500 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxLithium
Severe
How does the drug interact with Defrijet 500 Tablet:
Taking Defrijet 500 Tablet with lithium may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Lithium and Defrijet 500 Tablet, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience nausea, vomiting, loss of hunger, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, palpitations and confusion. Do not discontinue any medications without consulting a doctor.
DeferasiroxClopidogrel
Severe
How does the drug interact with Defrijet 500 Tablet:
Taking Defrijet 500 Tablet together with clopidogrel may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Although taking clopidogrel together with Defrijet 500 Tablet has a possibility of interaction, it can be taken if prescribed by your doctor. However, if you experience abdominal pain, bloating, dizziness, lightheadedness, red or black, tarry stools oe headache. Do not discontinue any medication without consulting your doctor.
DeferasiroxFenoprofen
Severe
How does the drug interact with Defrijet 500 Tablet:
Taking Fenoprofen and Defrijet 500 Tablet together can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Fenoprofen with Defrijet 500 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxRisedronic acid
Severe
How does the drug interact with Defrijet 500 Tablet:
Taking Risedronic acid (oral form) with Defrijet 500 Tablet can increase the risk of bleeding and ulcers in the stomach.

How to manage the interaction:
Taking Risedronic acid with Defrijet 500 Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of hunger, or black, tarry stools. Do not discontinue any medications without consulting a doctor.
DeferasiroxCilostazol
Severe
How does the drug interact with Defrijet 500 Tablet:
Co-administration of Defrijet 500 Tablet with cilostazol can increase the risk or severity of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Taking Defrijet 500 Tablet with cilostazol together can possibly result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as stomach pain, bloating, dizziness, lightheadedness, decreased hunger, nausea, vomiting (especially with fresh or dried blood that looks like coffee grounds), and red or black, tarry stools. Do not discontinue any medications without consulting a doctor.
DeferasiroxTiclopidine
Severe
How does the drug interact with Defrijet 500 Tablet:
Using Defrijet 500 Tablet together with ticlopidine may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Co-administration of Ticlopidine with Defrijet 500 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxKanamycin
Severe
How does the drug interact with Defrijet 500 Tablet:
Defrijet 500 Tablet may cause kidney problems and combining it with kanamycin may increase that risk.

How to manage the interaction:
Although taking Kanamycin and Defrijet 500 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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DEFERASIROX-500MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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DEFERASIROX-500MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
The blood levels and effects of caffeine may be enhanced by Defrijet 500 Tablet. Avoid consumption of caffeinated drinks during the treatment with Defrijet 500 Tablet. If you experience any unusual symptoms call a doctor.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ALUMINIUM HYDROXIDE
  • REPAGLINIDE
  • THEOPHYLLINE
  • BUSULFAN
  • ASPIRIN
  • CELECOXIB
  • DILTIAZEM
  • PARACETAMOL

Habit Forming

No

Special Advise

  • Monitor blood counts, liver function, and renal function monthly.
  • Monitor serum ferritin monthly to assess the patient’s response to therapy and minimize the risk of over-chelation.

Diet & Lifestyle Advise

  • Choose foods high in nutrients, such as fruits, vegetables, and whole grains.
  • Replace fatty protein sources with lean alternatives and consume modest quantities of healthy fat sources for improved well-being.
  • Create a diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
  • Instead of saturated and trans fats, choose monounsaturated and polyunsaturated fats (fish, nuts, and vegetable oils).
  • Select/prepare foods and beverages with fewer added sugars/caloric sweeteners.
  • Be mindful of salt; consume no more than 2,300 mg each day.
  • Limit or avoid alcohol and caffeine consumption.

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