COMBISURE 125MCG INHALER is a respiratory medication, primarily used to treat and prevent asthma and chronic obstructive pulmonary diseases (COPD) like bronchitis (inflammation of the lining of your bronchial tubes) and emphysema (shortness of breath). Asthma is a chronic (long-term) respiratory condition in which airways narrow, swell and produce extra mucus, leading to difficulty breathing. COPD is a group of lung diseases that causes obstructed airflow from the lungs.

COMBISURE 125MCG INHALER is a combination of two medicines, namely: Formoterol (bronchodilator) and Fluticasone (corticosteroids). Formoterol is a long-acting beta-agonist that relaxes the muscles in the airways and increases airflow to the lungs. Formoterol makes breathing easier by widening the airways. Fluticasone acts by blocking prostaglandin's production (chemical messengers) that cause inflammation (swelling) of the airways. Thereby, it provides relief from sneezing, runny or blocked nose and sinus discomfort. It helps to prevent asthma attacks in adults and children.

Your doctor will advise on how often you take COMBISURE 125MCG INHALER based on your medical condition. The common side effects of COMBISURE 125MCG INHALER include nausea, vomiting, respiratory tract infection, headache, sore throat, cough, bone, muscle or joint pain, increased heart rate, chills, tiredness and noisy breathing. Most of these side effects of COMBISURE 125MCG INHALER do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not use COMBISURE 125MCG INHALER to treat sudden severe symptoms of asthma or as a rescue inhaler. Brief your medical history if you have heart, liver, kidney diseases, high blood pressure, hypokalaemia (low potassium levels in the blood), aneurysm (swelling of an artery), pheochromocytoma (adrenal gland tumor), hyperadrenocorticism (high levels of cortisol), cataract and glaucoma, chickenpox or measles, immune system problem, seizure (fits), osteoporosis, and diabetes before taking COMBISURE 125MCG INHALER. Please check with your doctor if you are pregnant, currently breastfeeding or taking any other prescribed or non-prescribed medicines. COMBISURE 125MCG INHALER is not recommended for children below five years of age.

COMBISURE 125MCG INHALER is used to treat and prevent respiratory disorders like asthma and chronic obstructive pulmonary diseases (COPD). COMBISURE 125MCG INHALER improves pulmonary function and effectively treats and prevents the worsening of emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of your bronchial tubes). COMBISURE 125MCG INHALER is a combination of Formoterol (bronchodilator) and Fluticasone (corticosteroid). Formoterol relaxes the muscles in the airways and increases airflow to the lungs. It makes breathing easier by widening the airways. Fluticasone acts by blocking prostaglandin's production (chemical messengers) that cause inflammation (swelling) of the airways. Fluticasone has potent vasoconstrictive (narrowing of the blood vessels) and anti-inflammatory activity.

• Nausea
• Vomiting
• Respiratory tract infection
• Headache
• Sore throat
• Cough
• Bone, muscle or joint pain
• Increased heart rate
• Chills
• Tiredness
• Noisy breathing

Do not stop taking this medicine of your own unless advised by your doctor. Please do not use COMBISURE 125MCG INHALER to treat sudden severe symptoms of asthma or as a rescue inhaler. Before taking COMBISURE 125MCG INHALER, let your doctor know if have a history of heart, liver, kidney diseases, high blood pressure, diabetes, and other medical conditions. Special precautions should be taken in patients with a fungal, bacterial, parasitic, or viral infection and tuberculosis since nasal or inhaled corticosteroids like Fluticasone can cause secondary infections. Regular monitoring of potassium levels is recommended while taking COMBISURE 125MCG INHALER as it may cause low potassium levels in the blood. Please let your doctor know if you plan to become pregnant or are already pregnant and a lactating mother. COMBISURE 125MCG INHALER is not recommended for children below five years of age.

Drug-Drug Interaction: COMBISURE 125MCG INHALER may interact with fluid retention drugs (furosemide), corticosteroids (budesonide, mometasone, beclomethasone), bronchodilators (vilanterol, salmeterol, albuterol), respiratory drugs (ipratropium), drugs treating irregular heartbeat (sotalol) and blood pressure medicines (metoprolol).

Drug-Food Interaction: COMBISURE 125MCG INHALER may interact with grapefruit and grapefruit juice. Therefore, avoid intake of grapefruit while being treated with COMBISURE 125MCG INHALER.

Drug-Disease Interaction: If you have any allergic reactions to medicines, heart, liver, kidney diseases, high blood pressure, hypokalaemia (low potassium levels in the blood), aneurysm (swelling of an artery), pheochromocytoma (adrenal gland tumor), hyperadrenocorticism (high levels of cortisol), eye disorders like cataract and glaucoma, chickenpox or measles, immune system problem, seizure (fits), osteoporosis (weak and brittle bones) and diabetes, please inform your doctor before using COMBISURE 125MCG INHALER.

• FUROSEMIDE
• BUDESONIDE
• MOMETASONE
• BECLOMETASONE
• VILANTEROL
• SALMETEROL
• ALBUTEROL
• IPRATROPIUM
• SOTALOL
• METOPROLOL

• Do meditation, deep breathing, regular exercise and try progressive muscle relaxation techniques to get relief from stress and reduce the risk of an asthma attack.
• Know your triggers like allergens, such as pollen, dust and food items that make your asthma severe.
• Quit smoking and avoid passive smoking. Smoking also reduces the effectiveness of the medicine.
• Eat a healthy diet and exercise regularly to strengthen your breathing muscles and boost your immune system.
• Learning breathing exercises will help you move more air in and out of your lungs.

• It is advised to undergo blood examination to keep a check on your potassium levels since COMBISURE 125MCG INHALER can cause low potassium levels in the blood (hypokalaemia).
• Regularly monitor your blood sugar levels while using COMBISURE 125MCG INHALER since bronchodilators like Formoterol can cause low blood glucose levels.
• Consult your diabetologist if you have diabetes before using COMBISURE 125MCG INHALER so that your insulin or other diabetic medication can be adjusted accordingly to maintain your blood sugar levels.

Asthma: It is a chronic (long-term) respiratory condition in which airways narrow, swell, and produce extra mucus, leading to difficulty in breathing. The symptoms of asthma include wheezing (whistling sound while breathing), shortness of breath, chest tightness and cough, especially at night. The symptoms of mild persistent asthma may occur more than 2 times in a week and up to 4 nights in a month whereas, in case of severe persistent asthma, the symptoms occur several times every day and most nights. The treatment for asthma includes medication, breathing exercises and self-care.

Chronic obstructive pulmonary disease (COPD): It is a group of lung diseases with emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of bronchial tubes). The major cause of COPD is smoking tobacco. Also, long-term exposure to fumes and chemicals may lead to COPD. The symptoms include chronic cough, shortness of breath or wheezing (whistle sound while breathing).