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  1. Home
  2. Medicine

  3. Cathlyse 18 Injection 1's

Prescription drug
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Composition :

RETEPLASE-18MG

Manufacturer/Marketer :

Biochem Pharmaceutical Industries Ltd

Consume Type :

Parenteral

Expires on or after :

Return Policy :

Not Returnable

Therapeutic Class

[MISCELLANEOUS]

Country of origin

India

Manufacturer/Marketer address

Biochem Pharma, Lg 113 / A, Xth Central Mall, Mahavir Nagar, 90Ft Road, Next To D Mart, Kandivali - West, Mumbai - 400067.
Other Info - CAT0157

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:48 AM IST

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Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Safe if prescribed

Limited information is available. Please consult your doctor.

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Pregnancy

Consult your doctor

Please consult your doctor if you are pregnant. Your doctor will prescribe only if the potential benefits outweigh the potential risk to the foetus.

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Breast Feeding

Consult your doctor

Please consult your doctor if you are breastfeeding. Caution should be exercised whilst administering Cathlyse 18 Injection to a nursing mother.

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Driving

Safe if prescribed

Limited information is available. Please consult your doctor.

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Liver

Consult your doctor

The potential risks with the therapy of Cathlyse 18 Injection may be increased in patients with severe liver dysfunction and should be weighed against the anticipated benefits. Please consult your doctor.

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Kidney

Consult your doctor

The potential risks of Cathlyse 18 Injection therapy may be increased in patients with severe renal dysfunction and should be weighed against the anticipated benefits. Please consult your doctor.

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Children

Safe if prescribed

The efficacy and safety of Cathlyse 18 Injection in children have not been established.

Product Substitutes

Reference

  1. https://resources.chiesiusa.com/Retavase/RETAVASE_PI.pdf
  2. https://ciplamed-library.com/content/retefast-intravenous-bolus-injection
  3. https://www.nps.org.au/assets/medicines/45e6f404-ef25-4095-b6ed-a53300ff2519.pdf
  4. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e7b63b16-d911-478b-a445-b690a1360b48

About Cathlyse 18 Injection

Cathlyse 18 Injection is a tissue plasminogen activator indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to lower the risk of heart failure and death. STEMI is a very serious type of heart attack that occurs due to blockage of the heart’s major arteries.
 
Cathlyse 18 Injection contains Reteplase, which works by dissolving the blood clot that is blocking the heart blood vessel.
 
In some cases, Cathlyse 18 Injection may cause side effects such as bleeding, bruising at the injection site, nausea or vomiting. You are advised to talk to your doctor if any of the side effects persist or worsen.
 
Consult your doctor if you are pregnant or breastfeeding. The efficacy and safety of Cathlyse 18 Injection in children have not been established. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects/interactions.

Uses of Cathlyse 18 Injection

ST-elevation myocardial infarction (STEMI)

Medicinal Benefits Mweb

Key Benefits

Cathlyse 18 Injection is a tissue plasminogen activator indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to reduce the risk of heart failure and death. Cathlyse 18 Injection contains Reteplase that works by dissolving the blood clot that is blocking the heart blood vessel. It may also be indicated in the treatment of a recent left bundle branch block (a delay/blockage of electrical impulses to the left side of the heart).

Directions for Use

Cathlyse 18 Injection will be administered by a healthcare professional; do not self-administer.

Side Effects of Cathlyse 18 Injection

  • Bleeding
  • Bruising at the injection site
  • Vomiting
  • Nausea

Drug Warnings

Cathlyse 18 Injection should not be used if you are allergic to any of the components in Cathlyse 18 Injection, in patients with active internal bleeding, recent stroke, recent intracranial or intraspinal surgery or serious head trauma, intracranial neoplasm (brain tumour), arteriovenous malformation, or aneurysm (ballooning and weakened area in an artery), known bleeding diathesis (tendency to bleed or bruise easily), or severe uncontrolled hypertension. Cathlyse 18 Injection may cause bleeding, hypersensitivity reactions, or cholesterol embolism. Inform your doctor if you have/had recent major surgery, cerebrovascular disease, recent gastrointestinal/genitourinary bleeding, hypertension, subacute bacterial endocarditis, severe hepatic or renal disease, if you are over 75 years or if you are taking any oral anticoagulants. Consult your doctor if you are pregnant or breastfeeding. The safety and effectiveness of Cathlyse 18 Injection in children have not been established.

Drug-Drug Interactions

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ReteplaseCangrelor
Severe
ReteplaseIbrutinib
Severe

Drug-Drug Interactions

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ReteplaseCangrelor
Severe
How does the drug interact with Cathlyse 18 Injection:
Co-administration of Cangrelor with Cathlyse 18 Injection can increase the risk of bleeding.

How to manage the interaction:
Although taking Cangrelor and Cathlyse 18 Injection together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs, it's important to contact a doctor right away: difficulty with bleeding, complications, bruising, feeling dizzy or lightheaded, dark or sticky stools, intense headache, weakness, or bleeding or vomiting. Do not stop using any medications without talking to a doctor.
ReteplaseIbrutinib
Severe
How does the drug interact with Cathlyse 18 Injection:
Co-administration of Ibrutinib with Cathlyse 18 Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibrutinib with Cathlyse 18 Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
ReteplaseEnoxaparin
Severe
How does the drug interact with Cathlyse 18 Injection:
Combining Cathlyse 18 Injection with Enoxaparin can increase the risk or severity of bleeding.

How to manage the interaction:
Although there is a possible interaction between Enoxaparin and Cathlyse 18 Injection, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like bleeding, bruising, dizziness, or severe headache, it's important to call a doctor right away. Do not stop using any medications without talking to a doctor.
ReteplaseFondaparinux
Severe
How does the drug interact with Cathlyse 18 Injection:
Taking Cathlyse 18 Injection with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between fondaparinux and Cathlyse 18 Injection, you can take these medicines together if prescribed by your doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
ReteplaseApixaban
Severe
How does the drug interact with Cathlyse 18 Injection:
Coadministration of Cathlyse 18 Injection and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Cathlyse 18 Injection and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ReteplasePrasugrel
Severe
How does the drug interact with Cathlyse 18 Injection:
Taking Prasugrel with Cathlyse 18 Injection can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Prasugrel with Cathlyse 18 Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
ReteplaseDabigatran etexilate
Severe
How does the drug interact with Cathlyse 18 Injection:
Taking Dabigatran etexilate with Cathlyse 18 Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Cathlyse 18 Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Habit Forming

No

Diet & Lifestyle Advise

  • Include vegetables, fruits and whole grains in your diet.
  • Stop smoking.
  • Be physically active every day.
  • Aim for a healthy weight.
  • Limit the consumption of alcohol.
  • Manage stress with meditation.

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