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  1. Home
  2. Medicine

  3. Aprezo 20 Tablet 4's

Prescription drug
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Written By ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Composition :

APREMILAST-20MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIPSORIATICS

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
Other Info - APR0136

FAQs

Disclaimer

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Alcohol

Caution

Limit intake of alcohol, as this may increase the risk of serious side effects.

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Pregnancy

Caution

If you are pregnant, inform your doctor before taking Aprezo 20 Tablet. Consult your doctor if you become pregnant while taking Aprezo 20 Tablet.

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Breast Feeding

Caution

It is not known whether Aprezo 20 Tablet may pass into breast milk or not. If you are breastfeeding, inform your doctor before taking Aprezo 20 Tablet.

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Driving

Safe if prescribed

Aprezo 20 Tablet has no or negligible influence on the ability to drive and use machines.

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Liver

Caution

Aprezo 20 Tablet to be taken with caution, especially if you have a history of liver problems. Your doctor may adjust the dose of this medicine based on your condition.

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Kidney

Caution

Aprezo 20 Tablet to be taken with caution, especially if you have a history of kidney diseases. Your doctor may adjust the dose of this medicine based on your condition.

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Children

Unsafe

Aprezo 20 Tablet is not recommended for use in children and adolescents below 17 years.

Product Substitutes

Reference

  1. https://www.medicines.org.uk/emc/files/pil.3648.pdf
  2. https://www.drugs.com/cdi/apremilast.html

About Aprezo 20 Tablet

Aprezo 20 Tablet belongs to a class of drugs known as phosphodiesterase 4 (PDE4) inhibitors. It is used to treat Plaque psoriasis (scaly, itchy, and red patches on the skin), psoriasis arthritis (inflammation in the joints in people with psoriasis), and oral ulcers. Psoriasis is a chronic, painful, nontransmissible, deactivating and damaging disease. It can happen at any age and is most common in the age group 50 to 69. Psoriatic arthritis is a type of arthritis that some people with psoriasis experience.

Aprezo 20 Tablet contains Apremilast, a phosphodiesterase 4 (PDE4) inhibitor. Aprezo 20 Tablet works by blocking the action of some chemical messengers that are responsible for inflammation related to psoriatic arthritis (inflammation in the joints in people with psoriasis) and psoriasis (scaly, itchy, and red patches on the skin), and thus, lowers the signs and symptoms of these conditions.

Take Aprezo 20 Tablet as prescribed by your doctor. You are advised to take Aprezo 20 Tablet for as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience diarrhoea, vomiting, nausea, weight loss, and back pain. Most of these side effects of Aprezo 20 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Aprezo 20 Tablet should not be taken in the conditions like depression as it is getting worse with thoughts of suicide. Before starting Aprezo 20 Tablet, please inform your doctor if you have any allergy to Aprezo 20 Tablet and its part. Aprezo 20 Tablet not recommended for use in children and adolescents aged below 17 years. If you are pregnant or breastfeeding, ask your doctor for advice before taking this Aprezo 20 Tablet. Aprezo 20 Tablet does not affect the ability to drive and use machines.

Uses of Aprezo 20 Tablet

Plaque psoriasis, psoriasis arthritis, and oral ulcers caused by Behcet's disease.

Medicinal Benefits Mweb

Medicinal Benefits

Aprezo 20 Tablet is used in treating psoriatic arthritis; it decreases pain and swelling and may help improve flexibility in the affected joints. It is also used to treat moderate to severe plaque psoriasis (skin disease causes red, scaly patches to form on some areas of the body) in people who may benefit from medications). It is used to treat ulcers in the mouth in persons with Behcet's syndrome (a disease that results from blood vessel swelling in the body). Aprezo 20 Tablet works by blocking the action of some chemical messengers responsible for inflammation related to psoriatic arthritis and psoriasis, thus lowering the signs and symptoms of these conditions.

Directions for Use

Take Aprezo 20 Tablet as prescribed by your doctor. Your doctor determines the dose of the medicine based on your condition. Take Aprezo 20 Tablet with or without food. Swallow the Aprezo 20 Tablet as a whole with a glass of water. Do not crush, chew, or break it.

Side Effects of Aprezo 20 Tablet

  • Diarrhea
  • Vomiting
  • Nausea
  • Weight loss
  • Back pain

Drug Warnings

Inform your doctor before using Aprezo 20 Tablet, if you have previously had an allergic reaction (hypersensitivity). Before starting Aprezo 20 Tablet, please inform your doctor if you have depression and suicidal thoughts. Inform your doctor before taking Aprezo 20 Tablet if you have severe kidney problems. Inform your doctor while taking Aprezo 20 Tablet if you lose weight without meaning to. Aprezo 20 Tablet should not be taken in conditions like severe diarrhoea, nausea, and vomiting. Aprezo 20 Tablet not recommended for use in children and adolescents aged below 17 years. If you are pregnant or breastfeeding, ask your doctor for advice before taking this Aprezo 20 Tablet. Patients with rare hereditary galactose intolerance problems, total lactase deficiency or glucose-galactose malabsorption should not take Aprezo 20 Tablet.

Drug-Drug Interactions

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ApremilastCarbamazepine
Severe
ApremilastPhenytoin
Severe

Drug-Drug Interactions

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ApremilastCarbamazepine
Severe
How does the drug interact with Aprezo 20 Tablet:
Taking Aprezo 20 Tablet with carbamazepine can significantly reduce the blood levels of Aprezo 20 Tablet, which may make the medication less effective.

How to manage the interaction:
Taking Aprezo 20 Tablet with Carbamazepine together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
ApremilastPhenytoin
Severe
How does the drug interact with Aprezo 20 Tablet:
Coadministration of Phenytoin with Aprezo 20 Tablet may reduce the blood levels of Aprezo 20 Tablet, which may reduce effectiveness in treatment.

How to manage the interaction:
Although taking Phenytoin and Aprezo 20 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Without consulting a doctor, never stop taking any drugs.
ApremilastFosphenytoin
Severe
How does the drug interact with Aprezo 20 Tablet:
Coadministration of Fosphenytoin with Aprezo 20 Tablet may reduce the effectiveness of treatment.

How to manage the interaction:
Although taking Fosphenytoin and Aprezo 20 Tablet together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without talking to a doctor.
ApremilastNevirapine
Severe
How does the drug interact with Aprezo 20 Tablet:
Coadministration of Nevirapine with Aprezo 20 Tablet may decrease the blood levels of Aprezo 20 Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is a possible interaction between Aprezo 20 Tablet and Nevirapine, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ApremilastRifampicin
Severe
How does the drug interact with Aprezo 20 Tablet:
Taking Aprezo 20 Tablet with rifampicin can decrease the blood levels of Aprezo 20 Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Aprezo 20 Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
ApremilastMitotane
Severe
How does the drug interact with Aprezo 20 Tablet:
Coadministration of Mitotane with Aprezo 20 Tablet may reduce the effectiveness of treatment.

How to manage the interaction:
Although taking Aprezo 20 Tablet and Mitotane together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
ApremilastPrimidone
Severe
How does the drug interact with Aprezo 20 Tablet:
Coadministration of Aprezo 20 Tablet with primidone may decrease the blood levels of Aprezo 20 Tablet, which may make Aprezo 20 Tablet less effective in treating.

How to manage the interaction:
Although there is an interaction between Primidone and Aprezo 20 Tablet, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ApremilastEnzalutamide
Severe
How does the drug interact with Aprezo 20 Tablet:
Coadministration of Enzalutamide with Aprezo 20 Tablet may reduce the efficacy of treatment.

How to manage the interaction:
Although taking Aprezo 20 Tablet and Enzalutamide together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
ApremilastRifabutin
Severe
How does the drug interact with Aprezo 20 Tablet:
Coadministration of Aprezo 20 Tablet and Rifabutin may reduce the blood levels of Aprezo 20 Tablet.

How to manage the interaction:
Although there is a possible interaction between Aprezo 20 Tablet and Rifabutin, you can take these medicines together if prescribed by a doctor. In case you experience any symptoms, consult a doctor. Do not discontinue any medications without consulting a doctor.
ApremilastRifapentine
Severe
How does the drug interact with Aprezo 20 Tablet:
Rifapentine may decrease the blood levels of Aprezo 20 Tablet, which may make Aprezo 20 Tablet less effective in treating the condition.

How to manage the interaction:
Although taking Aprezo 20 Tablet and Rifapentine together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • RIFAMPICIN
  • PHENYTOIN
  • CARBAMAZEPINE
  • PHENOBARBITAL

Habit Forming

No

Special Advise

  • Aprezo 20 Tablet is a well-tolerated medicine. Mild stomach upset may arise early during the treatment.
  • Monitor your weight repeatedly as Aprezo 20 Tablet may lead to weight loss.
  • Inform your doctor immediately if you experience new or worsened depression, suicidal thoughts, unexplained weight loss, or other mood changes.

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

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